Trends in Onychomycosis Prescribing: A Single Center Retrospective Study Over 15 Years.
Authors: Wang Y, Geizhals S, Lipner SR PMID: 32441553 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patients' preferences of leave-on emollients- a survey on patients with atopic dermatitis.
Conclusion: Due to individual-dependent characteristics as well as different severity of atopic dermatitis, the indication of one best preparation for patients is problematic. However, we believe that our study is one of the milestones on the way to the best emollient individually tailored to the patient's skin. PMID: 32431184 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 22, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Topical tacrolimus with different frequency for exfoliative cheilitis: a pilot study.
Conclusion: Our data suggested that application of topical tacrolimus 0.1% ointment once a day and once two days had similar clinical effectiveness for sign and symptom relief in patients with exfoliative cheilitis. PMID: 32431191 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 22, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is Biologic Treatment of Hidradenitis Suppurativa During the COVID-19 Pandemic Different from Psoriasis Biologic Treatment?
Authors: Rosi E, Pimpinelli N, Prignano F PMID: 32432955 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 22, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Assessment of the benefit of achieving complete versus almost complete skin clearance in psoriasis: A patient's perspective.
Authors: Korman NJ, Malatestinic W, Goldblum OM, Murage MJ, Renda L, Lin CY, Lucas J, Middleton C, Lobosco S Abstract BACKGROUND: Psoriasis is characterized by thick and scaly plaques. The Dermatology Life Quality Index (DLQI) and Physician Global Assessment (PGA) can be used to define its severity. OBJECTIVE: To assess the impact of complete clearance of skin vs. almost clear skin across various disease measures. METHODS: Data were collected in a survey of US dermatologists and patients with psoriasis from November 2016-January 2017. Dermatologists completed a 6-point PGA (0 = clear skin, 1&t...
Source: Journal of Dermatological Treatment - May 22, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Outcome of Minimally Invasive Surgery for Digital Mucous Cyst: A 2-year Follow-up of Percutaneous Capsulotomy.
This study reported that percutaneous capsulotomy could be an effective method for DMCs treatment. The recurrence rate was low and patient satisfaction was good. Nail deformities could be improved with treatment. PMID: 32432965 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 22, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effectiveness of benzyl benzoate treatment on clinical symptoms and Demodex density over time in patients with rosacea and demodicosis: a real life retrospective follow-up study comparing low- and high-dose regimens.
Conclusion: These findings indirectly support a key role of the mite in rosacea and suggest that topical treatment with BB (+crotamiton), especially the higher dose, may be a useful alternative treatment for rosacea as well as for demodicosis. PMID: 32427504 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Psoriasis in difficult to treat areas: treatment role in improving health-related quality of life and perception of the disease stigma.
Conclusion: We identified itching as a mediator between the cutaneous extension of psoriasis and the impact on quality of life. We also documented the predominant role of nail psoriasis in defining the impact on the quality of life of the psoriatic patient. PMID: 32419527 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combination of targeted UVB phototherapy and calcipotriene versus targeted UVB alone in psoriasis: systematic review and meta-analysis of randomized controlled trials.
Conclusion: Addition of calcipotriene ointment may improve the efficacy of the targeted UVB phototherapy in the treatment of plaque-type psoriasis. PMID: 32419530 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison of psoriasis guidelines for use of apremilast in the United States and Europe: a critical appraisal and comprehensive review.
Conclusion: Apremilast is an effective and well-tolerated treatment option for patients with psoriasis and should be considered in the line of therapy that dermatologists discuss with their patients, especially those with contraindications to other systemic therapies such as biologics. Consideration should be given to the evidence-based recommendations of global dermatology organizations to help guide therapeutic decisions. PMID: 32419531 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of guselkumab compared with placebo and adalimumab in Korean patients with moderate-to-severe psoriasis: Post-hoc analysis from the phase III, double-blind, placebo- and active-comparator-controlled VOYAGE 1/2 trials.
Authors: Youn SW, Yu DY, Kim TY, Kim BS, Lee SC, Lee JH, Choe YB, Lee JH, Choi JH, Roh JY, Jo SJ, Lee ES, Shin MK, Lee MG, Jiang J, Lee Y Abstract BACKGROUND: The phase 3 studies, VOYAGE 1 and 2, were conducted to assess guselkumab in the treatment of patients with moderate-to-severe psoriasis. OBJECTIVES: To investigate the efficacy and safety of guselkumab in Korean patients. METHODS: The Korean sub-population of VOYAGE 1 and 2 study patients were included in this analysis. Efficacy and safety were evaluated through Weeks 24 and 28, respectively. RESULTS: Of 126 randomized Korean patients, 30, 63, and...
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Reorganization of a Northern Italy dermatology department during the COVID-19 pandemic: is it temporary or the beginning of a new era in dermatology?
We describe the reorganization of our Northern Italy dermatology department during COVID-19 pandemic, including teledermatology strategies. Considering the unknown duration of this emergency scenario we wonder if this is just a temporary measure or the beginning of a new era in dermatology departments' organization? PMID: 32419538 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Fractional CO2-assisted photodynamic therapy improves the clinical outcome and patient's satisfaction in toenail onychomycosis treatment: an intra-patient comparative single-center study.
Authors: Abdallah M, Abu-Ghali MM, El-Sayed MT, Soltan MY Abstract Background: Device-based therapies have been used for onychomycosis patients with intolerance to systemic treatments. Photodynamic therapy (PDT) improves onychomycosis, while fractional carbon dioxide (FrCO2) augments the topical drug delivery. Comparative studies between PDT alone and laser-assisted one are lacking.Objective: We aimed to evaluate the efficacy of PDT alone versus FrCO2 -assisted PDT for treatment of onychomycosis.Methods: Twenty-one patients with bilateral onychomycosis of toenails with nearly the same degree of affection were enrol...
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Survey-Based Study of Physician Practices Regarding Biotin Supplementation.
Authors: Waqas B, Wu A, Yim E, Lipner SR Abstract Biotin is an important cofactor in several metabolic pathways in humans. Biotin deficiencies are quite uncommon and there is limited data to support recommending it to treat hair, skin, and nail conditions. A 2017 FDA safety alert warned that biotin can interfere with laboratory testing resulting in incorrect diagnoses and even death. Therefore, our study objectives were to assess biotin recommendation practices and survey physician knowledge of biotin interference in routine laboratory tests. In a national survey of 149 physicians, we found that 43.9% of physicians...
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Safety of dupilumab in atopic patients during COVID-19 outbreak.
Authors: Napolitano M, Patruno C, Ruggiero A, Nocerino M, Fabbrocini G PMID: 32419563 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Split Face Comparative Study between Intradermal Tranexamic Acid and Erbium-YAG laser in Treatment of Melasma.
Conclusion: A promising results were obtained by both intradermal TA and erbium: YAG laser, however the TA yields a higher patient satisfaction because of its high efficiency and low cost. PMID: 32420770 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Management Strategies of Autoimmune bullous diseases during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19).
Authors: Chen P, Zhang G, Zhan Y Abstract Since late December 2019, an outbreak of the novel coronavirus disease, which is mainly characterized by pulmonary lesions, has spread quickly worldwide. With the spread of the novel coronavirus, the outpatient lines of hospitals have mostly shut down, which means that routine clinical diagnosis and treatment for autoimmune bullous diseases patients have been disturbed. Due to the serious condition of autoimmune bullous diseases patients, they are prone to immune suppression and circulatory failure, and are more susceptible to infection than healthy individuals. These patie...
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Proposition of standardized protocol for photodynamic therapy for vulvar lichen sclerosus.
CONCLUSION: Based on a literature review we suggest the following protocol for PDT in VLS: 5% 5-ALA as a photosensitizer applied for three hours under occlusion before irradiation at the dose of 120 J/cm2 with red light (590-760 nm) and intensity of 204 mW/cm2. PMID: 32420789 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The effectiveness of vismodegib in patients with advanced periocular basal cell carcinoma: a case series of 13 patients.
Authors: Villani A, Costa C, Cappello M, Fabbrocini G, Scalvenzi M PMID: 32421419 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologics for patients affected by Hidradenitis suppurativa in the COVID-19 era: data from a referral centre of Southern Italy.
Authors: Marasca C, Ruggiero A, Megna M, Annunziata MC, Fabbrocini G PMID: 32403954 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologics and small molecules in patients with scalp psoriasis: a systematic review.
CONCLUSION: Effective treatment of scalp psoriasis is essential for improving the quality of life of psoriasis patients. Both Biologics and small molecules proved efficacy. This review may help choosing the appropriate treatment in cases where scalp psoriasis is the main complaint. A unified measurement tool for scalp psoriasis severity is needed to facilitate comparisons. PMID: 32406275 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A survey of psoriasis patients on biologics during COVID-19: a single centre experience.
Authors: Burlando M, Carmisciano L, Cozzani E, Parodi A PMID: 32406283 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Vismodegib (ERIVEDGE) Pregnancy Prevention Programme: assessment of risk awareness.
CONCLUSION: Survey data suggest that the risk of teratogenicity with vismodegib has been effectively communicated to the prescribing community. PMID: 32406291 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Temporal Comparison of Biologic Medication Prices between the United States and Australia.
Authors: Muzumdar S, Wu R, Feng H PMID: 32407192 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison and Evaluation of Three Techniques for Treating Auricular Pseudocyst.
CONCLUSION: Local steroid injection should be the first choice for the treatment of auricular pseudocyst because of high satisfaction, favorable effectiveness and few sequelae. Where this method is ineffective, surgery should be used. PMID: 32410519 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Platelet-Rich Plasma as a Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis.
CONCLUSION: PRP is an autologous treatment that lacks serious adverse effects and effectively improves hair density and hair thickness in men and women with AGA. Future research should include low risk-of-bias RCTs to optimize treatment protocols, investigate variability amongst studies, and to obtain more data on hair thickness changes. PMID: 32410524 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/ β-catenin signaling pathway.
Conclusions: Microneedling combined with 5% minoxidil can improve AGA, and the underlying mechanism may involve activation of the Wnt/β-catenin signaling pathway. PMID: 32412314 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Topical Methotrexate in Dermatology: A Review of the Literature.
Conclusion: The quality of evidence for the utility of topical methotrexate in psoriasis is good, however, for other dermatologic diseases, the quality is poor. Topical MTX with improved delivery methods may be a viable tool against certain localized dermatologic conditions for patients who do not tolerate oral MTX. Further double-blinded randomized controled studies are needed to substantiate the utility of topical methotrexate. PMID: 32412810 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Ventilatory support in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: a systematic review and meta-analysis.
Authors: Phan K, Oh LJ, Issler-Fisher A, Rao A, Wong EH, Maitz P Abstract Introduction: Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are blistering cutaneous disorders that often manifest with epidermal and mucosal necrosis. In extreme cases, the upper or bronchial airways are threatened, necessitating intubation and mechanical ventilation. This systematic review and meta-analysis examines the prevalence of mechanical ventilation (MV) in patients with SJS or TENS, despite maximal medical therapy, and additionally aims to identify the risk factors associated with this requirement.Materials and...
Source: Journal of Dermatological Treatment - May 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A novel plant-derived compound is synergistic with 5-fluorouracil and has increased apoptotic activity through autophagy in the treatment of actinic keratoses.
Conclusions: We demonstrate that GZ17-6.02 exerts lethal effects on AK cells in vitro. We also demonstrate GZ17-6.02's superior efficacy against AK than the current standard of care, 5-fluorouracil, showing its promise both as a monotherapy and in combination with 5-fluorouracil. PMID: 32362152 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 6, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Mucous membrane pemphigoid and COVID-19 treated with high-dose intravenous immunoglobulins: a case-report.
Authors: Daneshpazhooh M, Soori T, Isazade A, Noormohammadpour P PMID: 32363963 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 6, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A challenging case of psoriasis flare-up after COVID-19 infection.
Authors: Nasiri S, Araghi F, Tabary M, Gheisari M, Mahboubi-Fooladi Z, Dadkhahfar S Abstract The immunosuppressive drugs used for the treatment of psoriasis may affect the clinical presentation and outcome of COVID-19 infection. Herein, we report a 73-year-old male patient with severe psoriasis being treated with cyclosporine (CsA) 100mg daily plus methotrexate (MTX) 7.5 mg weekly (biologic treatment was not accessible) who experienced disease flare-up after the discontinuation of psoriasis treatment during COVID-19 infection. PMID: 32363967 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 6, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Inpatient Teledermatology During the COVID-19 Pandemic.
Authors: Rismiller K, Cartron AM, Trinidad JCL PMID: 32364809 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 6, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Disease activity and treatment efficacy using patient-level Psoriasis Area and Severity Index scores from tildrakizumab phase 3 clinical trials.
Authors: Gordon KB, Reich K, Crowley JJ, Korman NJ, Murphy FT, Poulin Y, Spelman L, Yamauchi PS, Mendelsohn AM, Parno J, Rozzo SJ, Ellis CN Abstract Background: It is unclear whether primary efficacy outcomes in plaque psoriasis clinical trials represent residual disease during treatment.Objectives: To evaluate supplementing dichotomous efficacy with residual disease activity.Methods: This post hoc analysis used pooled, patient-level data after tildrakizumab 100 mg (N = 616) or placebo (N = 309) treatment from reSURFACE 1/2 (NCT01722331/NCT01729754) phase 3 clinical trials of pati...
Source: Journal of Dermatological Treatment - May 2, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effectiveness of cyclosporine A in patients with moderate to severe plaque psoriasis in a real-life clinical setting in Italy: the TRANSITION study.
Authors: Marsili F, Travaglini M, Stinco G, Manzoni R, Tiberio R, Prignano F, Mazzotta A, Cannavò SP, Cuccia A, Germino M, Bongiorno MR, Persechino S, Florio T, Pettinato M, Tabanelli M, Sarkar R, Aloisi E, Bartezaghi M, Orsenigo R Abstract Background: Cyclosporine A (CsA) is one of the systemic therapeutic options for moderate-to-severe psoriasis, based on its efficacy and rapidity of action. The current study investigated the response to CsA in patients with moderate-to-severe plaque psoriasis.Materials and Methods: TRANSITION was an observational, cross-sectional, multicentre study which evaluated the pro...
Source: Journal of Dermatological Treatment - May 2, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Predictors of drug survival of biologic therapies in psoriasis patients.
Conclusions: Although our study is retrospective of a relatively low number of patients, this is a preliminary study focusing on two different patient populations based on therapy response. PMID: 32351141 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 2, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and Safety of Active Vitamin D Supplementation in Chronic Spontaneous Urticaria Patients.
Conclusion: Vitamin D deficiency is more common in CSU patients as compared to healthy people and hence, alfacalcidol might have a beneficial role as add on therapy in CSU management with no reported side effects. PMID: 32345077 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dermoscopy-guided Mohs micrographic surgery in post-laser basal cell carcinomas: Is dermoscopy helpful for demarcation of the surgical margin?
Authors: Shin K, Kim HJ, Ko HC, Kim BS, Kim MB, Kim HS Abstract Background: Mohs micrographic surgery (MMS) in cases where the tumor margin is poorly defined to the naked eye can lead to the need to take an increased number of Mohs stages.Objective: To evaluate the usefulness of dermoscopy in determining MMS surgical margins of BCCs with a history of ablative laser treatment.Methods: Patients were randomly allocated to naked eye (n = 69) or dermoscopy (n = 64) groups by the surgical margin detection method. Surgical outcomes of 133 post-laser BCC patients treated with MMS were analyzed.R...
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Molluscum contagiosum in paediatric patients: to treat or not to treat? Could a personalised Imiquimod regimen be the answer to the dilemma?
Conclusions: Our study is one of the few case-control studies in paediatric population carried out with such long-term follow-up. Efficacy of this personalised treatment, scarce recurrence, absence of cicatricial sequelae and lack of necessity for deep sedation, in the case of children with disseminated lesions, makes the use of Imiquimod the first line of treatment compared with other destructive treatments or with no-treatment at all. PMID: 32347136 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Optimizing doxepin therapy in dermatology: Introducing blood level monitoring and genotype testing.
Authors: Myers B, Reddy V, Chan S, Thibodeaux Q, Brownstone N, Koo J Abstract Doxepin, a tricyclic antidepressant, is the most efficacious antipruritic available to dermatologists, however its use is often suboptimal because of significant interindividual variability in doxepin plasma levels and clinical response between patients taking the same dose. As result, the Food and Drug Administration approves a maximum dose of 300 mg of doxepin per day and a 10 mg per cc liquid doxepin concentrate. These allow patients to significantly increase or decrease their dose, due to either a lack of clinical effica...
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Medicare and Medicaid Spending Trends for Immunomodulators Prescribed for Dermatologic Conditions.
Authors: Price KN, Atluri SSS, Hsiao JL, Shi VY Abstract Immunomodulators are the most expensive prescription medications used in dermatology for chronic skin conditions. Each year, rising costs for immunomodulators pose significant financial burdens on patients and the healthcare system as a whole. Using the Centers for Medicare and Medicaid Services (CMS) we collected Medicare Part D (Medicare-D) and Medicaid spending data for immunomodulators with dermatologic indications or off-label use from 2012-2018. The average annual spending and average annual spending per dosage unit (AASPDU) was calculated for each of t...
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Danger of Neglecting Melanoma during the COVID-19 Pandemic.
Authors: Gomolin T, Cline A, Handler MZ Abstract Due to the COVID-19 pandemic, planned medical and surgical activities are being postponed. For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. Neglecting melanoma during this crisis can result in increased mortality, morbidity and healthcare costs. With the COVID-19 pandemic evolving and no clear solutions in sight, it is time for the prospective evaluation of teledermatology. However, dermatologists should be cautious and continue seeing patients with pigmented lesions in person due...
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dupilumab provides rapid and sustained improvement in SCORAD outcomes in adults with moderate-to-severe atopic dermatitis: combined results of four randomized phase 3 trials.
Authors: Barbarot S, Wollenberg A, Silverberg JI, Deleuran M, Pellacani G, Armario-Hita JC, Chen Z, Shumel B, Eckert L, Gadkari A, Lu Y, Rossi AB Abstract Background: Dupilumab, a first-in-class therapy targeting the two key cytokines involved in the persistent underlying inflammatory pathway in atopic dermatitis (AD), is approved for treatment of moderate-to-severe AD in Europe, USA, Japan and several other countries.Objective: To assess dupilumab effects on SCORing Atopic Dermatitis (SCORAD) and component scores (objective and subjective SCORAD) over time in adults with moderate-to-severe AD.Methods: This post ho...
Source: Journal of Dermatological Treatment - May 1, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Therapeutic effects of ephrin B receptor 2 inhibitors screened by molecular docking on cutaneous squamous cell carcinoma.
Conclusion: EphB2 small-molecule inhibitors had anti-CSCC effects, establishing a solid theoretical basis for clinical research. PMID: 32338086 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 29, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Conducting Clinical Trials During the COVID-19 Pandemic.
Authors: Collier EK, Hsiao JL, Shi VY Abstract The COVID-19 pandemic has greatly impacted dermatology clinical trial operations due to mandated governmental and institutional shut-downs and newly implemented restrictions. During this unprecedented time, measures should be taken to maintain research conduct compliance while also ensuring the safety of trial staff and participants. Herein, we underscore the challenges facing dermatology trials during the COVID-19 pandemic, and offer strategies to maintain compliant and safe conduct. PMID: 32343162 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 29, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A retrospective study on comparing the surgery and microneedles radiofrequency and microwaves treatment in axillary osmidrosis.
Conclusions: For the advantages and disadvantages of these three treatments, axillary osmidrosis patients should choose the proper therapy with comprehensive considerations. PMID: 32343164 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 29, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Immunomodulators and immunosuppressants in the era of SARS-CoV-2 - could laboratory tests be the missing link?
Authors: Alpalhão M, Filipe P PMID: 32323591 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 25, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A subset analysis of efficacy and safety outcomes from phase 3 clinical studies of ixekizumab for the treatment of patients with severe plaque psoriasis.
Conclusion: Our data support the efficacy, early onset of action, and maintained response of ixekizumab as observed in previous trials, and highlight the complexity of comprehensively defining disease severity in psoriasis. PMID: 32314628 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Deferred time of delivery of biologic therapies in patients with stabilized psoriasis leads to a 'perceived satisfaction': a multicentric study.
Conclusions: The administration of biologic drugs with prolonged intervals maintains the same effectiveness as standard administration and produces a 'perceived satisfaction' in psoriatic patients. PMID: 32314934 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Moderate-to-severe plaque psoriasis patients treated with ixekizumab: early real-world outcomes and adverse events.
Conclusion: This analysis represents the first investigation of early clinical outcomes in a small cohort of Canadian patients treated with ixekizumab. Overall, complete and rapid skin clearance was observed. Future studies including more patients and longer follow-up time are crucial to confirm these findings. PMID: 32319327 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research