Greater Cumulative Benefits from Ixekizumab versus Ustekinumab Treatment over 52 Weeks for Patients with Moderate-to-Severe Psoriasis in a Randomized, Double-Blinded Phase 3b Clinical Trial.
CONCLUSIONS: IXE showed greater cumulative clinical benefit than UST. PMID: 30799638 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 27, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Powered muscle stimulators: An investigation into newly FDA 510(k) approved devices marketed for muscle toning and aesthetic benefit.
This study aims to describe marketing trends and reporting of adverse effects of powered muscle stimulators. METHODS: We performed a cross-sectional retrospective analysis of records from the United States FDA database for 510(k) premarket approval of powered muscle stimulators between January 1, 2000 and December 31, 2018. The FDA MAUDE database was reviewed for adverse events reported with device usage. RESULTS: One hundred and seventeen devices received 510(k) premarket approval between 2000 and 2018, with the first approval occurring in 2001. Initially, devices were marketed to assist with muscle toning and str...
Source: Journal of Dermatological Treatment - February 27, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Qualitative analysis and reproducibility assessment of the Scalp Itch Numeric Rating Scale among patients with moderate to severe plaque psoriasis of the scalp.
Authors: Wang Y, Coyne K, Sofen H, Santanello N, Currie B, Zhang Z, Nograles K Abstract BACKGROUND: Pruritus is a prevalent and bothersome symptom of scalp psoriasis. Validated scales assessing scalp itch are needed to assess treatment efficacy. OBJECTIVE: To evaluate comprehensibility and reproducibility of the Scalp Itch Numeric Rating Scale (NRS), a novel scale being used in a phase 3 study of apremilast. METHODS: The Scalp Itch NRS, Modified Whole Body Itch NRS, Global Assessment of Psoriasis Severity-Scalp (GAPS-S), and Global Impression of Change-Scalp Itch (GIC-SI) were assessed among patients with m...
Source: Journal of Dermatological Treatment - February 14, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Decade Retrospective Study of Light/Laser Devices in Treating Nasal Rosacea.
CONCLUSION: The multiple, sequential light/laser devices can be safely used in nasal rosacea with various degrees efficacies based on different types. PMID: 30732485 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Lymphoprolipherative skin reactions induced by anti-TNF α: An open question.
We describe 5 patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis- one patient, Crohn's disease- one patient and ankylosing spondylitis- three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Histological and immunophenotypical analysis was typical for mycosis fungoides in all of them. Anti-TNFα agents were stopped with regression of the skin rash. A direct effect of anti-TNFα agents in the development of lymphoproliferative reactions (including MF) is suggested and further analyzed. Treatment cessation can be ther...
Source: Journal of Dermatological Treatment - February 8, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is there an association between isotretinoin therapy and adverse mood changes? A prospective study in a cohort of acne patients.
CONCLUSION: The relationship between isotretinoin and depression is the most debated aspect of isotretinoin therapy. Our results link isotretinoin to an overall improvement in psychological wellbeing, even in patients suffering with stable mental illness. However, we also found that a small minority of patients are susceptible to severe mood deterioration, particularly in conjunction with severe physical side effects. PMID: 30717601 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 7, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologic TNF-alpha inhibitors in the treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: a systemic review.
CONCLUSION: Biologic TNF-alpha inhibitors are a safe and effective treatment for SJS-TEN. But further, larger randomized controlled trials need to be conducted to provide more evidence for clinical application. PMID: 30702955 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Laser and Laser Compound Therapy for Melasma: A Meta-Analysis.
Authors: Zhang Y, Zheng X, Chen Z, Lu L Abstract BACKGROUND: Treatment of melasma is challenging because its pathogenesis is unclear and it is prone to recurrence. We performed a meta-analysis to evaluate the efficacy and safety of laser and laser compound therapy for melasma. METHODS: We searched the Cochrane, Embase, and Medline databases for all relevant studies published from inception to July 2018. All randomized controlled trials of melasma describing treatment with lasers or laser compound therapy were included. RESULTS: A total of 346 patients were enrolled in nine RCT studies. Laser therapy and las...
Source: Journal of Dermatological Treatment - February 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

JAK/STAT inhibitors for the treatment of atopic dermatitis.
DISCUSSION: JAK inhibitors will most certainly be the first oral targeted option when topical therapy fails. With good oral bioavailability and lack of immunogenicity, they address some of the limitations of biologics. Yet to be defined is whether selective JAK 1 inhibitors or non-selective JAK inhibitors will provide the best equilibrium of efficacy versus side effects. Less clear is the position in the therapeutic ladder for topical JAK inhibitors, although an unmeet need exists in the topical treatment of AD. PMID: 30703333 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Radiation therapy techniques in the treatment of skin cancer: an overview of the current status and outlook.
Authors: Pashazadeh A, Boese A, Friebe M Abstract Nonmelanoma skin cancer (NMSC) is a major health concern due to its high incidence rate, its negative impact on the quality of life of patients as well as the associated economic burden to the healthcare system. Surgery is currently the primary treatment offered for skin cancer patients but not applicable or available in all cases. Radiation therapy (RT), with its long successful history in the management of cancer, has shown to be an effective alternative or complementary method in cutaneous oncology. Specifically, for dermatology applications, RT is very often the...
Source: Journal of Dermatological Treatment - February 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Ocular findings in patients with psoriasis: Is it related to the side effects of treatment or to psoriasis itself? A case-control study.
Authors: Ghalamkarpour F, Baradaran-Rafii A, Sadoughi MM, Abdollahimajd F, Younespour S, Zargari O, Rudolph RI Abstract OBJECTIVES: To assess ocular abnormalities in psoriatic patients (new-cases vs. patients under treatment) in comparison with healthy controls. METHODS: A total of 200 psoriatic patients and 100 healthy controls were enrolled in this prospective, observational study. The demographic data of the individuals were recorded. Dermatological and ophthalmological examinations were conducted; ocular surface disease index (OSDI), Schirmer and tear break-up time (TBUT) values were also measured. RESU...
Source: Journal of Dermatological Treatment - February 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Studying the efficacy of a new radical treatment for acne vulgaris using a surgical technique.
CONCLUSION: This newly developed surgical technique can be used as a basic treatment option for acne vulgaris. The implications of these findings include the prevention of patient psychological distress and avoidance of side effects of medications. PMID: 30706730 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The association of mycophenolate mofetil and human herpes virus infection.
Conclusion MMF is a commonly used steroid-sparing agent used to treat dermatological conditions. This review highlights that MMF is positively associated with cytomegalovirus infection. The presented studies were heterogeneous in study design and detection method, with the majority completed on renal transplant patients. Further studies are needed to shed light on the association of MMF with HHV. PMID: 30676825 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 26, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The 308-nm Excimer Laser Stimulates Melanogenesis via the Wnt/ β-Catenin Signaling Pathway in B16 cells.
In this study, we explored the role of the 308-nm excimer laser in treatment of vitiligo and the molecular mechanisms underlying melanin biosynthesis in melanocytes after 308-nm excimer laser radiation. MATERIALS AND METHODS: The B16 cells were irradiated at doses of 0 mJ/cm2, 100 mJ/cm2, 300 mJ/cm2 and 600 mJ/cm2 using a 308-nm excimer laser and then cultured for an additional 24, 48 or 72 hours. Melanogenesis and tyrosinase activity in cells were measured by biochemical methods. The expression of tyrosinase, MITF, Wnt3α and β-catenin was analyzed by Western blotting. ...
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Consumer Preferences of Antifungal Products for Treatment and Prevention of Tinea Pedis.
Authors: Kang R, Lipner S Abstract Tinea pedis is a common condition seen in clinical practice and has a significant impact on quality of life. Recommendations of over-the-counter antifungal products based on consumer preferences may guide dermatologists in treating patients with tinea pedis and preventing onychomycosis recurrences. Our study aimed to determine consumer preferences of antifungal products for tinea pedis, focusing on features that may guide purchases and usage. A search was performed for antifungal products used to treat athlete's foot on Amazon.com as of 2018, and the top one percentile of over-the...
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of autologous whole blood or serum therapy for chronic spontaneous urticaria: A systematic review and meta-analysis.
CONCLUSIONS: Our meta-analysis suggested that AWB therapy and AST are not significantly more effective in alleviating CSU symptoms than the placebo treatment. PMID: 30661442 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Psoriasis-Associated Itch: Etiology, Assessment, Impact, and Management.
Authors: Pithadia DJ, Reynolds KA, Lee EB, Wu JJ Abstract Pruritus, a very broad, subjective, and complex symptom, troubles the majority of patients with psoriasis. However, the subjective and multidimensional nature of the symptom renders it challenging for patients to appropriately communicate their experiences with itch to providers. This review explores current perspectives regarding the underlying mechanisms, assessment tools, burden, and treatment modalities for psoriatic pruritus. It emphasizes the significance of a incorporating a standardized, thorough, and verified metric that incorporates severity, distr...
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical and erythema-Directed imaging evaluation of Papulo-Pustular rosacea with topical ivermectin: A 32 weeks duration study.
CONCLUSIONS: IVM is a valuable therapeutic option in mild/moderate PPR. Erythema-directed digital photography enhances erythema changes visualization compared to clinical observation alone. PMID: 30663445 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Forrest III duodenal ulcers during treatment with adalimumab for psoriasis.
Authors: Chiriac A, Ancuta C, Mihai C PMID: 30663463 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Assessment of adherence to eczema treatment in Hong Kong children.
This study examined the psychometric properties of the translated Chinese version of PETS (C-PETS) among parents and caregivers of children with eczema. PETS was translated into Chinese and data obtained from a convenience sample of 147 Chinese participants from a regional hospital in Hong Kong. The internal consistency of C-PETS with a Cronbach's α of 0.93 and good test-retest reliability with weighted Kappa ranging from 0.74 to 0.89. Significant positive correlations were found among the C-PETS, Children's Dermatology Life Quality Index (r = 0.25, p = 0.002), and Severity Grading of Atop...
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Randomized Placebo-controlled Clinical Trial on Efficacy and Safety of Topical 10% Potassium Hydroxide for Molluscum Contagiosum Treatment in Children.
Authors: Giner-Soriano M, Teixidó C, Marsal JR, Díez O, Pera H, Vlacho B, Morros R, working group for the clinical trial IJG-KOH-201410 Abstract Introduction Our objective was to assess efficacy, safety and tolerance of topical potassium hydroxide (KOH) 10% for treating Molluscum contagiosum (MC) in children. Material and Methods Randomized, double-blind, placebo-controlled clinical trial including all children 2-16 years with MC infection attending pediatrician primary healthcare visits. The treatment was KOH 10% gel applied once daily up to clearing (maximum 30 days). Results KOH 10% showed superior...
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Tinea Versicolor of the Neck As Side Effect of Topical Steroids For Alopecia Areata.
CONCLUSION: Tinea versicolor of the neck should be included among a rare but possible side effect of prolonged application of high potency topical steroids on the scalp. These cases reinforce the importance of careful dermatologic examination and recommend preventive measures in patients with alopecia areata that are using these drugs. PMID: 30668183 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Black Tea Dressings - A Rapidly Effective Treatment for Facial Dermatitis.
CONCLUSION: Black tea dressings represent an effective treatment option for facial dermatitis. Its advantages include lack of side effects, low cost, and easy availability. PMID: 30668184 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Topical Ketoconazole: A Systematic Review of Current Dermatological Applications and Future Developments.
This article aims to review the literature on topical KTZ's efficacy and adverse effects, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments. METHODS: A PubMed search was done to include randomized-controlled trials focusing on the use of topical KTZ on human subjects. RESULTS: Forty studies with 4566 patients were included in this review. Topical KTZ is clinically effective for the treatment of Malassezia-related conditions such as seborrheic dermatitis and pityriasis versicolor with a reported efficacy of 63-90% and 71-89%, respectively. DISCUSSION: ...
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Institute for Clinical and Economic Review (ICER) Psoriasis Update 2018: What it means for dermatologists treating moderate-to-severe plaque psoriasis.
This report demonstrates a need for more consensus guidelines for the use of biologics in the treatment of psoriasis, and perhaps consideration of costs within these guidelines. PMID: 30668188 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Retrospective Analysis of the use of Tap Water Iontophoresis for Focal Hyperhidrosis at a District General Hospital: The Patients' Perspective.
Authors: Gollins CE, Carpenter A, Steen C, Bulinski H, Mahendran R Abstract Tap water iontophoresis as a treatment for focal hyperhidrosis, is given as an initial series of treatments in hospital followed by home maintenance treatments. Our study assessed quality of life and perception of hyperhidrosis with the use of iontophoresis. All patients treated with iontophoresis at our hospital from 2012 - 2017 were retrospectively assessed (n = 82, mean age 34 years; 60% female). 50 of the 82 patients (mean age 34 years; 60% female) had a pre-treatment DLQI (mean 12.6). Twenty three of these patients (mean ...
Source: Journal of Dermatological Treatment - January 18, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

An Update on Topical Photodynamic Therapy for Clinical Dermatologists.
Authors: Nguyen K, Khachemoune A Abstract INTRODUCTION: Photodynamic therapy (PDT) involves the application of a topical photosensitizer, irradiation with light, and oxygen to produce cytotoxic reactive oxygen species that selectively destroy damaged cells while leaving normal skin intact. Topical PDT is a commonly used treatment for non-melanoma skin cancers (NMSCs) due to its excellent clearance rate and cosmetic outcomes. However, PDT is emerging as an off-label treatment modality for many dermatological conditions. METHODS: A literature review using MEDLINE was performed to identify randomized controlled tr...
Source: Journal of Dermatological Treatment - January 18, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison of prognosis in centrofacial, panfacial and hairline vitiligo: a prospective cohort study.
Authors: Zhang L, Zhang C, Xiang L PMID: 30640572 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 16, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A case of infective endocarditis associated with atopic dermatitis perioperatively treated with dupilumab.
CONCLUSIONS: Dupilumab may be effective in AD cases as preparation for cardiac surgery. PMID: 30628496 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Stevens Johnson Syndrome and Toxic Epidermal Necrolysis - an Australian analysis of treatment outcomes and mortality.
CONCLUSION: There was an improvement in mortality in those who were treated with IVIg and supportive care compared to those who were treated with systemic steroids and supportive care. Early admission into burns unit may also improve mortality outcomes. However, treatment paradigms in skin care and supportive measures have improved over the length of the study period, which makes definitive conclusions difficult. PMID: 30632424 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A review of the FDA's 510(k) approvals process for electromagnetic devices used in body contouring.
In this study, we aimed to characterize the evolution and safety of electromagnetic devices marketed in the U.S. over the last two decades. METHODS: We examined records from a U.S. FDA database documenting premarket approval of electromagnetic devices between January 1, 2000 and October 31, 2018. Additionally, we searched the Manufacturer and User Facility Device Experience (MAUDE) database for reports of adverse events. RESULTS: Thirty-one devices were approved from 2012-2018. Initially marketed to temporarily reduce muscle pain and cellulite, indications for these devices have expanded. The MAUDE database reveale...
Source: Journal of Dermatological Treatment - January 9, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of Using Fractional CO2 Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions.
Authors: Ghasemloo S, Gauthier Y, Ghalamkarpour F Abstract BACKGROUND: Vitiligo is a common depigmenting skin disorder, characterized by patchy loss of skin color and finding effective treatment has remained a challenging issue. METHODS: A paired (half-body) randomized clinical trial study was done to compare the efficacy and the safety of narrowband ultraviolet B (NB-UVB) plus fractional CO2 versus NB-UVB alone in stimulation of marginal repigmentation of vitiliginous patches. One side of the body was randomly treated with a fractional CO2 laser and NB-UVB twice weekly, while the other side was exposed only to...
Source: Journal of Dermatological Treatment - December 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Ultrasound as a Diagnostic and Interventional Aid at Point-of-Care in Dermatology Clinic: A Case Report.
We report a patient who presented with a tender subcutaneous mass that was diagnosed and treated using point-of-care ultrasound-guidance at the dermatology clinic. Ultrasound revealed features consistent with a ganglion cyst, which was subsequently injected with triamcinolone acetonide under ultrasound-guidance with resolution of symptoms upon follow-up one month later. Our study demonstrates the utility of ultrasound as an effective, time-efficient diagnostic and interventional aid that can modify dermatology practice. PMID: 30592244 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Improving Health Literacy and Treatment Understanding of Hidradenitis Suppurativa using Group Educational Interventions.
Authors: Prussick L, Tonelli S, Gottlieb AB, Joshipura D, Alomran A, Zancanaro P, Kachuk C, Dumont N, Rosmarin D Abstract BACKGROUND: Hidradenitis suppurativa (HS) is a chronic immune mediated skin disorder characterized by inflamed, painful abscesses most commonly located in the intertriginous regions that may lead to significant scarring and social stigma. It is unclear how much patients with HS understand about their disease. OBJECTIVE: We sought to evaluate baseline knowledge of patients who have HS, as well as to evaluate if an educational intervention of a teaching session about the disease will help incr...
Source: Journal of Dermatological Treatment - December 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris.
Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris. J Dermatolog Treat. 2018 Dec 24;:1-22 Authors: Queille-Roussel C, Nielsen J, Lacour JP Abstract BACKGROUND: It is important to determine the vasoconstrictor potencies of topical corticosteroids used to treat psoriasis to ensure appropriate clinical use. OBJECTIVE: To compare the vasoconstrictive potencies of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5...
Source: Journal of Dermatological Treatment - December 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The journey for US psoriasis patients prescribed a topical: a retrospective database evaluation of patient progression to oral and/or biologic treatment.
Authors: Wu JJ, Lu M, Veverka KA, Smulders M, Papademetriou E, Yu J, Feldman SR Abstract BACKGROUND: A specific sequence for psoriasis (PsO) therapy has not been defined. OBJECTIVES: This retrospective, observational cohort study characterized pathways of PsO treatment over 3 years for newly diagnosed patients initially treated with a topical medication. METHODS: Adult PsO patients from the Explorys database (March 1 2011 to June 30 2015) were grouped according to medication-use patterns: 1) discontinued therapy; 2) topical therapy only; 3) switched/added an oral agent; and 4) switched/added a biologic agen...
Source: Journal of Dermatological Treatment - December 19, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab in the therapy of psoriasis and psoriatic arthritis: a safe choice in clinical practice.
Authors: Chiricozzi A PMID: 30526155 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 13, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Omalizumab treatment in patients with severe chronic spontaneous urticaria: consideration from real-life experience in Italy.
Authors: Asero R PMID: 30526156 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 13, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Oral small molecules for the treatment of atopic dermatitis: a systematic review.
CONCLUSION: Preliminary results demonstrate that oral small molecules are an effective treatment option in AD with minimal side effects. Additional randomized studies with larger sample sizes are needed to determine the efficacy and long-term side effects of these novel therapies. PMID: 30501539 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 7, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of Alopecia Areata.
Authors: Fabio R, Barbara M, Daniela P, Elisabetta S Abstract Background Alopecia areata (AA) is a non-scarring auto-immune hair disorder. Recent researches explained the role of growth factors (GFs) in hair follicle cycling. The main reservoir of GFs are alpha-granules of platelets and novel procedures have been implemented aimed at collecting platelet-rich plasma (PRP). PRP has been safely implemented in many medical application and has also been successfully used as alternative cell-based therapies for the treatment of hair growth disorder, among which also AA. Objectives By mean of a randomized double-blinded, ...
Source: Journal of Dermatological Treatment - December 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rapid, persistent, and simultaneous remission of urticaria and severe atopic dermatitis after treatment with omalizumab.
This article reports the rapid and complete remission of concomitant chronic spontaneous urticaria and atopic dermatitis, obtained in a woman of 32 years, after treatment with omalizumab, without adverse events. PMID: 30513060 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Recurrent oedema of the uvula in a patient with chronic spontaneous urticaria successfully treated with omalizumab.
We describe a case of a 62-year old woman had had recurring uvula oedema and chronic urticaria, not responder to antihistamines and oral corticosteroids. After 6 months of treatment with omalizumab and antihistamines, no urticaria recurrence was reported and no new episodes of angioedema had occurred. Our experience showed that omalizumab might be effective in patients with recurrent uvula oedema associated to urticaria. PMID: 30513061 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo.
CONCLUSIONS: This study indicates that conventional and intensified treatment for NSV seem to be comparable. The intensified treatment might be more effective to speed up the onset of repigmentation, but larger prospective studies are needed to objectify these findings. PMID: 30497304 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 2, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment goals in psoriasis from a patient perspective: a qualitative study.
CONCLUSION: There is a great variety and inter-individual difference in treatment goals. Therefore, we recommend to define individualized patient-defined treatment goals, as every patient with psoriasis requires a tailor made treatment program. PMID: 30482070 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Serum YKL-40 in patients with psoriasis vulgaris treated by narrow-band UVB phototherapy.
This study aimed to investigate the serum levels of Chitinase-3-like protein 1 (YKL-40) in patients with psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy. METHODS: This study was designed as a cross-sectional case-control. This study included 30 patients with psoriasis vulgaris and 20 healthy individuals. Psoriasis Area and Severity Index (PASI) score were used to evaluate the patients with psoriasis vulgaris before and after treatment. All patients were treated 2 times per week for 3 months with NB-UVB phototherapy. Enzyme-linked immunosorbent assay (ELISA) was used to assess se...
Source: Journal of Dermatological Treatment - November 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo.
CONCLUSION: NB-UVB phototherapy is an effective treatment for vitiligo, especially NSV. Repigmentation persisted in 80% of patients at 1-year after cessation of phototherapy. PMID: 30474443 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 27, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient preferences for attributes of topical anti-psoriatic medicines.
Conclusion The insight obtained in this work can provide guidance to pharmaceutical drug product design and has also potential to improve patient care through the acknowledgement of patient preferences in clinical practice. PMID: 30470146 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Omalizumab treatment in a 12 year-old girl with chronic spontaneous urticaria.
This article reports effective and safe treatment of a 12 years old girl with add-on omalizumab. PMID: 30462557 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 23, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Chronic spontaneous urticaria treated with omalizumab: report of two cases.
Authors: Malara G, Sciarrone C Abstract Chronic spontaneous urticaria (CSU) is a relatively common skin disease whose etiopathogenesis, as well as other factors influencing disease manifestations, are not fully understood. Mast cell function is recognised as having a central role in CSU signs and symptoms. Therapeutic options are limited; a number of drugs, recommended by international guidelines for the management of urticaria, lack regulatory approval for CSU and are prescribed off label. Omalizumab, a recombinant humanized anti IgE antibody, has recently received the approval for CSU treatment in Europe after an...
Source: Journal of Dermatological Treatment - November 23, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

YouTube Videos on Oral Systemic Therapies for Psoriasis: A Cross-Sectional Analysis.
Authors: Reynolds KA, Pithadia DJ, Lee EB, Wu JJ PMID: 30457412 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 22, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research