A retrospective study on comparing the surgery and microneedles radiofrequency and microwaves treatment in axillary osmidrosis.
Conclusions: For the advantages and disadvantages of these three treatments, axillary osmidrosis patients should choose the proper therapy with comprehensive considerations. PMID: 32343164 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 29, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Immunomodulators and immunosuppressants in the era of SARS-CoV-2 - could laboratory tests be the missing link?
Authors: Alpalhão M, Filipe P PMID: 32323591 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 25, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A subset analysis of efficacy and safety outcomes from phase 3 clinical studies of ixekizumab for the treatment of patients with severe plaque psoriasis.
Conclusion: Our data support the efficacy, early onset of action, and maintained response of ixekizumab as observed in previous trials, and highlight the complexity of comprehensively defining disease severity in psoriasis. PMID: 32314628 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Deferred time of delivery of biologic therapies in patients with stabilized psoriasis leads to a 'perceived satisfaction': a multicentric study.
Conclusions: The administration of biologic drugs with prolonged intervals maintains the same effectiveness as standard administration and produces a 'perceived satisfaction' in psoriatic patients. PMID: 32314934 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Moderate-to-severe plaque psoriasis patients treated with ixekizumab: early real-world outcomes and adverse events.
Conclusion: This analysis represents the first investigation of early clinical outcomes in a small cohort of Canadian patients treated with ixekizumab. Overall, complete and rapid skin clearance was observed. Future studies including more patients and longer follow-up time are crucial to confirm these findings. PMID: 32319327 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Demystifying pharmaceutical patient assistance programs.
Authors: Collier EK, Price KN, Hsiao JL, Shi VY Abstract Prescription drug costs impose a significant financial burden on the United States healthcare system. Patients with chronic dermatologic diseases often require long-term and expensive prescription drugs. In an effort to expand drug availability, pharmaceutical companies fund patient assistance programs (PAPs) to assist disadvantaged patients in gaining access to high-priced brand name medications with no suitable therapeutic alternative. Patients and clinical staff often face difficulty navigating the various PAPs. Herein, we seek to explore the utility, crit...
Source: Journal of Dermatological Treatment - April 22, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Indirect comparisons of ixekizumab versus three interleukin-23 p19 inhibitors in patients with moderate-to-severe plaque psoriasis - efficacy findings up to week 12.
Conclusion: Ixekizumab provides a faster onset of effect and earlier clinical benefits than guselkumab, tildrakizumab, or risankizumab in patients with moderate-to-severe psoriasis, as reflected by higher levels of skin improvement than with these IL-23 p19 inhibitors up to week 12. PMID: 32299269 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologics for psoriasis patients in the COVID-19 era: more evidence, less fears.
Authors: Megna M, Ruggiero A, Marasca C, Fabbrocini G PMID: 32301363 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effect of narrow-band ultraviolet B phototherapy, methotrexate, and combined narrow-band ultraviolet B phototherapy with methotrexate on serum cathelicidin and vitamin D in patients with psoriasis vulgaris.
This study aimed to evaluate the efficacy of narrow-band ultraviolet B (NB-UVB) phototherapy, methotrexate, and combined NB-UVB phototherapy with methotrexate in the treatment of psoriasis vulgaris and to assess their effects on serum cathelicidin and vitamin D.Methods: This study was conducted on 60 patients with psoriasis vulgaris. They were divided into three groups (20 patients each); Group (A) was treated with NB-UVB phototherapy. Group (B) was treated with methotrexate. Group (C) was treated with combined NB-UVB phototherapy with methotrexate. Patients were assessed with Psoriasis Area and Severity Index (PASI score)...
Source: Journal of Dermatological Treatment - April 18, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Study of Biosurfactant Extract from Corn Steep Water as a Potential Ingredient in Antiacne Formulations.
Authors: Rodríguez-López L, Rincón-Fontán M, Vecino X, Cruz JM, Moldes AB Abstract This is a novel work that includes the use of a biosurfactant extract obtained from corn milling industry (named BS-CSW), with antimicrobial activity, as ingredient in formulations to treat acne vulgaris. With this purpose, it was established an incomplete experimental design with 3 independent variables, based on the concentration of non-nano zinc oxide (ZnO) (0-2%), BS-CSW (0-5%) and salicylic acid (0-2%). This design allowed to obtain a theoretical model that calculates the inhibitory effect on Cutibact...
Source: Journal of Dermatological Treatment - April 18, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Relevant associations between alexithymia and health-literacy in persons with psoriasis.
Conclusion:. A more elevated alexithymia score is associated with lower health literacy. Further studies of these associations may contribute to a more comprehensive perspective of psoriasis. To know a patient's alexithymia level and HL needs may guide health care personnel's understanding of possible associations between health status, clinical presentation, behaviour, and response to treatment. PMID: 32286098 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Measurement of the serum zonulin levels in patients with acne rosacea.
This study aimed to evaluate the zonulin levels in acne rosacea.Methods: A total of 61 individuals, 30 diagnosed with acne rosacea and 31 healthy controls, were included in this study. There was no difference between the two groups in terms of age, gender, and body mass index. Zonulin was studied using the enzyme-linked immunosorbent assay.Results: The serum zonulin levels were found to be significantly higher in the patient group than in the control group (18.5 ± 2.9 ng/ml and 13.2 ± 2.7 ng/ml, respectively; p
Source: Journal of Dermatological Treatment - April 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Off-Label Studies on Anakinra in Dermatology: A Review.
Conclusion: Anakinra is a potential option for patients with certain difficult-to-treat dermatologic diseases, given its relatively benign adverse effect profile and its effectiveness in a wide array of conditions. Overall, anakinra appears to be a promising option in the treatment of numerous dermatologic inflammatory conditions refractory to first line therapies, but further and higher-quality data is needed to clarify its therapeutic role. PMID: 32279586 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Ustekinumab in the treatment of patients with hidradenitis suppurativa: multicenter case series and systematic review.
Conclusion: These findings suggest that ustekinumab may be an effective and safe option for patients with HS who fail to respond to first-line therapies. PMID: 32279593 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Clinical and Electron Microscopic Evaluation of the Impact of Pulsed Dye Laser Techniques on Solar Lentigines (Randomized Clinical Trial).
CONCLUSION: The two techniques of pulsed dye laser are efficient for solar lentigines treatment. PMID: 32281430 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Mycophenolate mofetil and lichen planopilaris: systematic review and meta-analysis.
Conclusions: The current evidence for MMF remains limited. However, it appears to be a potential treatment option for patients with severe or recalcitrant LPP who have failed hydroxychloroquine and other immunosuppressants. PMID: 32281437 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo.
Authors: Anbar T, Abd El Raheem T, Bassiouny DA, Fawzy MM, El Maadawi Z, Farouk N, Hassan M Abstract Background: Cobblestoning is the most common complication of minipunch grafting.Objective: To assess the value of silicone gel application following minipunch grafting and the histopathological and immunohistochemical changes in cases with cobblestoning.Methods: Minipunch grafting was performed in two similar vitiligo lesions in 27 cases with stable vitiligo. After healing, silicone gel was applied twice daily on one lesion while zinc oxide ointment was applied to the other lesion serving as a control. Four biopsies...
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dupilumab for atopic dermatitis: what are patients learning on YouTube?
Authors: Pithadia DJ, Reynolds KA, Lee EB, Wu JJ PMID: 32281445 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The management of biologics in dermatologic patients in the 2019-nCoV era.
Authors: Plachouri KM, Georgiou S PMID: 32281897 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 15, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combined oral isotretinoin and Candida antigen versus either agent alone in the treatment of plane warts.
Conclusions: Candida antigen, oral isotretinoin and a combination of both represent potential effective and safe modalities for the treatment of plane warts, with the Candida antigen alone as the most effective. PMID: 32271637 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 11, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biological treatment use amid the COVID-19 era, a close look at the unresolved perplexity.
Authors: Shanshal M PMID: 32255383 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 9, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

SECURE-Psoriasis: A de-identified registry of psoriasis patients diagnosed with COVID-19.
Authors: Balogh EA, Heron C, Feldman SR, Huang WW PMID: 32266851 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 9, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial.
Conclusion: The PN filler injection is effective and safe for periorbital rejuvenation. PMID: 32248707 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 8, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologic therapy for psoriasis during the covid-19 outbreak is not a choice.
Authors: Bardazzi F, Loi C, Sacchelli L, Di Altobrando A PMID: 32248724 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 8, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Therapeutic outcome of diphencyprone and its correlation with serum cytokine profile in alopecia areata.
DISCUSSION: Diphencyprone reduced the level of Th1, Th17 and Th9 cytokines and increased the level of Th2 cytokines (IL-4) in the present study, which induced remission and promoted hair regrowth. PMID: 32249656 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 8, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of non-surgical treatments for androgenetic alopecia in men and women: a systematic review with network meta-analyses, and an assessment of evidence quality.
Conclusions: While newer treatments like LLLT may be more efficacious than more traditional therapies like 5% minoxidil, the efficacy of the more recent treatment modalities needs to be further validated by future RCTs. PMID: 32250713 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 8, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of brodalumab in the treatment of scalp and nail psoriasis: results from three phase 3 trials.
Conclusions: Brodalumab was associated with clearance of scalp psoriasis through 12 weeks and improvements in nail psoriasis, including complete nail clearance, through 52 weeks. PMID: 32250714 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 8, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

COVID-19: Challenges and opportunities for dermatology response.
Authors: Chawla S Abstract As the world faces an unprecedented challenge in the novel coronavirus disease-2019 (COVID-19) pandemic, which as of 21 March 2020 has had 287,239 confirmed cases and 11,921 number of deaths worldwide, its consequences have reached all facets of medicine, including dermatology.1 It remains a rapidly evolving scenario with guidance being updated regularly to reflect new information. Whilst it presents unique challenges to dermatology, it also presents an opportunity to help drive the development of new infrastructure to adapt and improve dermatology practice. PMID: 32241193 [PubMed - a...
Source: Journal of Dermatological Treatment - April 5, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparative cost-effectiveness of tildrakizumab and other commonly used treatments for moderate-to-severe psoriasis.
Authors: Wu JJ, Jia X, Zhao Y, Carrico J, Brodtkorb TH, Mendelsohn A, Lowry S, Feldman SR, Armstrong A Abstract Objectives: To compare the cost-effectiveness of tildrakizumab with other commonly used biologics and apremilast as the first-line treatment for moderate-to-severe plaque psoriasis from a US health plan's perspective.Methods: A 10-year cost-effectiveness model was developed to compare the incremental cost per extra month with a Psoriasis Area and Severity Index (PASI) 75 response. Patients were assumed to receive one of the treatments evaluated as their first-line treatment at the outset of the analysis. Nonresponders (PASI
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab during pregnancy: a case report and review of literature.
Authors: Gallo L, Ruggiero A, Balato A, Megna M, Fabbrocini G PMID: 32233899 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Work/study productivity gain and associated indirect cost savings with guselkumab compared with adalimumab in moderate-to-severe psoriasis: results from the VOYAGE 1 study.
Conclusions: Guselkumab was superior to adalimumab for improvement in WPL and associated indirect cost savings, and its use may reduce the economic burden of psoriasis. PMID: 32233940 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Intralesional Injection of Vitamin D in Verruca Vulgaris Increases Cathelicidin (LL37) Expression; Therapeutic and Immunohistochemical Study.
Conclusions: Intralesional injection of vitamin D is effective and safe treatment for verruca vulgaris and causes increase in LL37 expression. PMID: 32237947 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

An Assessment of United States Dermatology Practices during the COVID-19 Outbreak.
This study examines the activity level of dermatology practices during the United States COVID-19 outbreak.Methods: We performed scripted phone calls to 60 dermatology practices in six different counties in the United Stated during the COVID-19 outbreak. We assessed if practices are open and if they are serving patients with urgent and non-urgent conditions.Results: Of the 60 dermatologists selected for the study, 55 were successfully contacted (92% contact rate). Of these practices, 29 (53%) were open, 17 (31%) were only seeing urgent patients and 9 (16%) were closed. New York, New York had 2 (20%) open offices which was ...
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Teledermatology: a useful tool to fight COVID-19.
Authors: Villani A, Scalvenzi M, Fabbrocini G PMID: 32238000 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Examining Correlation of Altmetric Score and Citation Number in Dermatology Journal Articles.
Conclusions: Online attention does not necessarily correspond with dissemination through traditional citation. While Altmetric scores convey much information about online dissemination, both Altmetric scores and citation numbers should be taken into account when evaluating a publication's impact. PMID: 32238001 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Oral isotretinoin combined with topical clobetasol 0.05% and tacrolimus 0.1% for the treatment of frontal fibrosing alopecia: A randomized controlled trial.
Authors: Mahmoudi H, Rostami A, Tavakolpour S, Nili A, Teimourpour A, Salehi Farid A, Abedini R, Amini M, Daneshpazhooh M Abstract Background: Frontal fibrosing alopecia (FFA) is a scarring alopecia with no promising treatment.Objective: To evaluate the additive efficacy of oral isotretinoin to topical treatments.Methods: Between November 2017 and August 2018, FFA patients were randomly assigned to receive either isotretinoin (20mg/d) plus topical treatments (clobetasol 0.05% and tacrolimus 0.1%) or monotherapy with topical treatments. Treatments' efficacy was evaluated through Frontal Fibrosing Alopecia Severity I...
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Cross-Sectional Study of Sun-Related Behaviours in the Internet Era.
Authors: Tong E, Phan K, Smith SD Abstract Objectives: To identify the use and purchasing behaviour of sunscreen products over the internet by Australian females, and factors contributing to these.Methods: A cross sectional study of 1065 Australian female participants aged 18 and over was performed in August 2019, utilising an online questionnaire to collect descriptive data regarding current demographics and behaviours in sunscreen product use, online sunscreen product purchasing, sunscreen product preferences and barriers to use, and sun exposure behaviours.Results: 57% of 1065 participants have used the internet...
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A consistent skin care regimen leads to objective and subjective improvements in dry human skin: investigator-blinded randomized clinical trial.
Conclusions: A consistent skin care regimen should be an integral component of management of dry skin. PMID: 32239984 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biological treatment during COVID-19 outbreak.
Authors: Sriwijitalai W, Wiwanitkit V PMID: 32223353 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 2, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision.
CONCLUSION: Autologous keratin and fibroblast as filler is an effective option for moderate-severe depressed scars correction with long-term efficacy and high satisfactory. PMID: 32216729 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 30, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Educational Video Promotes Durable Knowledge About Actinic Keratoses in Patients with Field Cancerization: A Pseudorandomized, Single-blind, Controlled Pilot Study.
CONCLUSION: A video decision aid for treatment of diffuse AKs improved durable patient knowledge. PMID: 32208999 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 29, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Targeted therapies for patients with moderate-to-severe psoriasis: a systematic review and network meta-analysis of PASI response at 1 year.
Conclusions: This NMA demonstrated that evaluated IL-17 and IL-23 inhibitors outperformed other biological therapies after one year. Risankizumab had a higher probability of achieving PASI outcomes than all other biologics, except brodalumab and guselkumab, where no significant difference could be concluded. PMID: 32202445 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Absolute and relative psoriasis area and severity index (PASI) treatment goals and their association with health-related quality of life.
Conclusion: Absolute PASI appeared to be a feasible alternative to PASI response for determining treatment success, reflecting HrQoL improvements in an equal manner. PMID: 32202943 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Value of reflectance confocal microscopy for the monitoring of rosacea during treatment with topical ivermectin.
Conclusions: RCM enables anti-inflammatory effect monitoring of topical ivermectin by determining mite presence. Quantifying exact mite number, and inflammatory and vascular characteristics is challenging due to device limitations. In its current form, RCM seems of limited value for noninvasive follow-up of rosacea in clinical practice. PMID: 32189533 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 20, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Should patients stop their biologic treatment during the COVID-19 pandemic.
Authors: Bashyam AM, Feldman SR PMID: 32191143 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 20, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

An economic evaluation of risankizumab versus other biologic treatments of moderate to severe plaque psoriasis in Japan.
Authors: Saeki H, Ishii K, Joshi A, Bensimon AG, Yang H, Kawaguchi I Abstract OBJECTIVE: To evaluate the cost-effectiveness of risankizumab versus other biologic treatments (adalimumab, infliximab, ustekinumab, secukinumab, brodalumab, ixekizumab, and guselkumab) of moderate-to-severe psoriasis in Japan. METHODS: A Markov cohort-level model was constructed to estimate quality-adjusted life years (QALYs) and costs for each treatment over a lifetime horizon. The model simulated patients' transition through one line of active biologic therapy followed by best supportive care and death. Transition probabilities wer...
Source: Journal of Dermatological Treatment - March 19, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Use of Virtual Reality in Non-Burn Dermatological Care - A Review of the Literature.
Authors: Harper HE, Hirt PA, Lev-Tov H Abstract Virtual Reality (VR) is the artificial depiction of a three-dimensional (3D) environment using computer-generated technology which allows users to interact with a simulated setting. VR has been used in a variety of clinical scenarios due to its efficacy as a distraction intervention, reducing anxiety and pain associated with medical procedures. The aim of this review is to provide clinicians with an overview of VR use in clinical dermatology. This review identifies studies that utilized VR in the management of skin diseases and discusses considerations for its future ...
Source: Journal of Dermatological Treatment - March 17, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Balancing Rules with Common Sense in the Protection of Human Subjects.
Authors: Svoboda SA, Balogh EA, Feldman SR PMID: 32162573 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 13, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Pulsed Dye Laser Alone Versus Its Combination With Topical Ivermectin 1% In Treatment of Rosacea: A Randomized Comparative Study.
Conclusion This study supports the efficacy of PDL treatment for patients with rosacea. PDL could be more effective when combined with ivermectin 1% cream. PMID: 32141785 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 7, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Off-Label Dermatologic Uses of IL-17 Inhibitors.
Authors: Wu KK, Dao H Abstract IL-17 inhibitors, including secukinumab, brodalumab, and ixekizumab, have been U.S. Food and Drug Administration (FDA) approved for the treatment of psoriasis. In addition to psoriasis, IL-17 has been implicated in the pathophysiology of other inflammatory skin conditions. This review aims to synthesize and interpret the literature evaluating the off-label dermatologic uses of IL-17 inhibitors. We performed searches in PubMed and ClinicalTrials.gov for clinical trials, observational studies, case series, and case reports evaluating non-psoriatic uses of the three IL-17 inhibitors. Stu...
Source: Journal of Dermatological Treatment - March 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research