Rapid, persistent, and simultaneous remission of urticaria and severe atopic dermatitis after treatment with omalizumab.
This article reports the rapid and complete remission of concomitant chronic spontaneous urticaria and atopic dermatitis, obtained in a woman of 32 years, after treatment with omalizumab, without adverse events. PMID: 30513060 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Recurrent oedema of the uvula in a patient with chronic spontaneous urticaria successfully treated with omalizumab.
We describe a case of a 62-year old woman had had recurring uvula oedema and chronic urticaria, not responder to antihistamines and oral corticosteroids. After 6 months of treatment with omalizumab and antihistamines, no urticaria recurrence was reported and no new episodes of angioedema had occurred. Our experience showed that omalizumab might be effective in patients with recurrent uvula oedema associated to urticaria. PMID: 30513061 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo.
CONCLUSIONS: This study indicates that conventional and intensified treatment for NSV seem to be comparable. The intensified treatment might be more effective to speed up the onset of repigmentation, but larger prospective studies are needed to objectify these findings. PMID: 30497304 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 2, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment goals in psoriasis from a patient perspective: a qualitative study.
CONCLUSION: There is a great variety and inter-individual difference in treatment goals. Therefore, we recommend to define individualized patient-defined treatment goals, as every patient with psoriasis requires a tailor made treatment program. PMID: 30482070 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Serum YKL-40 in patients with psoriasis vulgaris treated by narrow-band UVB phototherapy.
This study aimed to investigate the serum levels of Chitinase-3-like protein 1 (YKL-40) in patients with psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy. METHODS: This study was designed as a cross-sectional case-control. This study included 30 patients with psoriasis vulgaris and 20 healthy individuals. Psoriasis Area and Severity Index (PASI) score were used to evaluate the patients with psoriasis vulgaris before and after treatment. All patients were treated 2 times per week for 3 months with NB-UVB phototherapy. Enzyme-linked immunosorbent assay (ELISA) was used to assess se...
Source: Journal of Dermatological Treatment - November 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo.
CONCLUSION: NB-UVB phototherapy is an effective treatment for vitiligo, especially NSV. Repigmentation persisted in 80% of patients at 1-year after cessation of phototherapy. PMID: 30474443 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 27, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient preferences for attributes of topical anti-psoriatic medicines.
Conclusion The insight obtained in this work can provide guidance to pharmaceutical drug product design and has also potential to improve patient care through the acknowledgement of patient preferences in clinical practice. PMID: 30470146 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Omalizumab treatment in a 12 year-old girl with chronic spontaneous urticaria.
This article reports effective and safe treatment of a 12 years old girl with add-on omalizumab. PMID: 30462557 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 23, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Chronic spontaneous urticaria treated with omalizumab: report of two cases.
Authors: Malara G, Sciarrone C Abstract Chronic spontaneous urticaria (CSU) is a relatively common skin disease whose etiopathogenesis, as well as other factors influencing disease manifestations, are not fully understood. Mast cell function is recognised as having a central role in CSU signs and symptoms. Therapeutic options are limited; a number of drugs, recommended by international guidelines for the management of urticaria, lack regulatory approval for CSU and are prescribed off label. Omalizumab, a recombinant humanized anti IgE antibody, has recently received the approval for CSU treatment in Europe after an...
Source: Journal of Dermatological Treatment - November 23, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

YouTube Videos on Oral Systemic Therapies for Psoriasis: A Cross-Sectional Analysis.
Authors: Reynolds KA, Pithadia DJ, Lee EB, Wu JJ PMID: 30457412 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 22, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of Cutaneous Lichen Planus (Part 2): A Review of Systemic Therapies.
CONCLUSION: Clinicians may have a broader perspective on the efficacy of treatments across all study profiles. PMID: 30451042 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 20, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Special Aspects of Biologics Treatment in Psoriasis: Management in Pregnancy, Lactation, Surgery, Renal Impairment, Hepatitis and Tuberculosis.
CONCLUSION: The aim of this review, other than providing a summarized update on the clinical knowledge on this special topic, is also to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate the use of biologics in these special patient categories and therefore draw definite conclusions on their safety profile. PMID: 30428753 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

JAK-inhibitors in dermatology. Current evidence and future applications.
Authors: Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L Abstract The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitilig...
Source: Journal of Dermatological Treatment - November 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Chronic Spontaneous Urticaria or Autoinflammatory Disease? The Therapeutic Effect of Omalizumab in a Pediatric Patient.
We describe the clinical case of a 9-year-olf-female with recurrent monthly episodes of fever, arthralgia, abdominal pain, and urticaria-angioedema who did not respond to steroids associated with antihistamines, however showed the complete resolution of the disease with omalizumab. PMID: 30426806 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Survey of Acne-Related Post-Inflammatory Hyperpigmentation in the Middle East.
Authors: Abanmi A, Al-Enezi M, Al Hammadi A, Galadari I, Kibbi AG, Zimmo S Abstract Acne vulgaris is a common inflammatory skin disease in the Middle East, similar to other regions of the world. In the Middle East, there is a relatively high proportion of patients with darker pigmentation (Fitzgerald skin types III-VI) who are prone to developing post-inflammatory hyperpigmentation (PIH) as a sequela of acne. Data are sparse on the frequency and characteristics of PIH throughout the world. What information is available indicates that pigmentation problems can be very bothersome for patients and are often quite long...
Source: Journal of Dermatological Treatment - November 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The effect autophagy-enhancing peptide in moisturizer on atopic dermatitis: A randomized controlled trial.
CONCLUSION: The moisturizer with autophagy-stimulating property provides a good therapeutic option to mild-to-moderate atopic dermatitis by contributing to skin barrier restoration and control of inflammation. PMID: 30427231 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus.
Authors: Xie J, Ao C, Li J, Jiang L, Liu H, Zeng K Abstract Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infections. Urethral meatus warts are uncommon. And many treatments are limited by a difficult approach, recurrences, and potential complications. In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4h treatment of 5-aminolevulinic acid (ALA), patients received photodynamic therapy (PDT). Each patient received HPV test before every PDT cycle. The frequency of PDT was depend...
Source: Journal of Dermatological Treatment - November 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Cost-effectiveness Analysis and Safety of Erythromycin 4%Gel and 4% Chlorhexidine Scrub for Pitted Keratolysis Treatment.
Authors: Leeyaphan C, Bunyaratavej S, Taychakhoonavudh S, Kulthanachairojana N, Pattanaprichakul P, Chanyachailert P, Ongsri P, Arunkajohnsak S, Limphoka P, Kulthanan K Abstract BACKGROUND: Studies of Pitted keratolysis (PK) treatment are limited. OBJECTIVES: To study cost-effectiveness and to compare the safety of 4% chlorhexidine scrub with 4% erythromycin gel, for PK infections. Materials and methods This cohort study was conducted on naval rating cadets with a clinical diagnosis of PK at Chumpol Naval Rating School, Thailand in 2016. Participants were randomly treated with either 4% erythromycin gel or 4% c...
Source: Journal of Dermatological Treatment - November 13, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A clinical and immunological study of phototoxic regimen of ultraviolet A for treatment of alopecia areata: A randomized controlled clinical trial.
CONCLUSIONS: Phototoxic regimen of topical PUVA deserves a place among therapeutic tools used in management of alopecia areata especially in more extensive conditions where intralesional corticosteroids would not be suitable. PMID: 30411986 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Lichen planopilaris: Retrospective study on the characteristics and treatment of 291 patients.
Authors: Babahosseini H, Tavakolpour S, Mahmoudi H, Balighi K, Teimourpour A, Ghodsi SZ, Abedini R, Ghandi N, Lajevardi V, Kiani A, Kamyab K, Mohammadi M, Daneshpazhooh M Abstract Lichen planopilaris (LPP) is an immune-mediated cicatricial alopecia. The main clinical presentations of LPP include classic form, frontal fibrosing alopecia (FFA), and Graham-Little-Piccardi-Lassueur syndrome (GLPLS). We reviewed medical records of all 291 patients diagnosied with LPP from 2006 to 2017 in Department of Dermatology, Tehran University of Medical Sciences. LPP was more common in women than men. Lichen planus (LP) was seen i...
Source: Journal of Dermatological Treatment - November 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment with secukinumab in multi-comorbid patients with psoriatic arthritis.
We report two cases of patients with PsA, one of them with a 14-year-long medical history, and the other with lung involvement. Several different DMARDs with overall modest efficacy and lack of tolerability were used in both cases before switching the patients to secukinumab. Secukinumab allowed for a rapid improvement of the patients' symptoms without any safety concern. Our experience may be useful to the current knowledge on 'real world' use of secukinumab, which appears to effective and safe in challenging patients with comorbidities and poor tolerability to previous used biological agents. PMID: 30403897 [PubMed -...
Source: Journal of Dermatological Treatment - November 9, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Successful therapy of plaque-type psoriasis with secukinumab in patients with multiple comorbidities treated with previous biologic therapies.
CONCLUSIONS: The present three cases add further evidence that secukinumab is effective and well tolerated in difficult to treat psoriatic patients with multiple comorbidities, namely HBV, latent TBC infection, and hepatic impairment. PMID: 30403898 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 9, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical Safety and Efficacy of Curcumin Use for Oral Lichen Planus: A Systematic Review.
The objective of this review is to evaluate the existing evidence for the safety of curcumin in treating OLP as well as its efficacy compared with that of corticosteroids. METHODS: We reviewed the published literature by searching PubMed, EMBASE, EBSCO and Cochrane Library and then retrieved and analyzed several variables from patient records. RESULTS: Nine studies met the inclusion criteria, including six randomized, double-blind clinical trials; two pilot clinical trials; and one case report. A total of 259 OLP patients were included in the systematic review. Seven studies showed statistically significant differe...
Source: Journal of Dermatological Treatment - November 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Chronic urticaria in a child affected by atopic dermatitis: effective treatment with omalizumab.
This article describes a clinical experience in a 7-year-old girl with chronic spontaneous urticaria and atopic dermatitis, resistant to therapy with antihistamines and topical steroid. Omalizumab treatment not only allowed complete remission of chronic spontaneous urticaria but also significantly improved atopic dermatitis symptoms. The off-label use of omalizumab was well tolerated and no adverse events were reported. PMID: 30388916 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Advanced basal cell carcinoma: when a good drug is not enough.
Authors: De Giorgi V, Savarese I, Gori A, Scarfi F, Topa A, Trane L, Portelli F, Innocenti A, Covarelli P PMID: 30388924 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A clinicoepidemiological study of topical corticosteroid misuse at a tertiary care centre.
CONCLUSION: Non-prescriptional sale of TCS is the major factor responsible for TCS abuse in India. Creating awareness (both amongst patients and prescribers) and adequate dermatology training to undergraduate medical students is the need of the hour. PMID: 30394142 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - November 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of pioglitazone plus phototherapy vs. phototherapy in patients with plaque type psoriasis: a double blinded randomized controlled trial.
Authors: Ghiasi M, Ebrahimi S, Lajevardi V, Taraz M, Azizpour A Abstract INTRODUCTION: Thiazolidinediones have shown a good therapeutic effect in psoriasis treatment with no major adverse effects. The purpose of this study was to evaluate and compare the therapeutic effects of the combination of phototherapy and Pioglitazone with the phototherapy alone on plaque psoriasis patients. METHODS AND MATERIALS: 60 adults with plaque type psoriasis entered the study. They were randomly divided into two groups; one with pioglitazone and one with placebo and both underwent 30 sessions of phototherapy during 10 weeks. Bef...
Source: Journal of Dermatological Treatment - November 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Down-titration of omalizumab in a patient with chronic spontaneous urticaria.
This article reports the history of a patient affected by chronic spontaneous urticaria, unresponsive to antihistamines, who received omalizumab, according to a personalized schedule. Prolonged administration of low dosage drug provided a good and long-lasting control of symptoms. This experience suggests that omalizumab could be used at low dose, with personalized plans, to reduce the risk of adverse events and costs of treatment. PMID: 30351196 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 24, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treating Moderate Plaque Psoriasis: Prospective 6-Month Chart Review of Patients Treated With Apremilast.
CONCLUSIONS: Most patients with moderate psoriasis receiving apremilast had improved at 6-month follow-up. Safety and tolerability were consistent with the safety profile of apremilast. PMID: 30339049 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 21, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Adverse Cutaneous Effects of Neratinib.
We present a case of a woman on neratinib for HER-2 positive infiltrating ductal carcinoma of the right breast who presented to the dermatology clinic with changes to the fingernails, acne, and a rash on the face. Physical examination revealed erythema, induration, and some serum crust along the lateral nail folds of the right 4th and left 3rd digits as well as monomorphic acneiform papules and pustules on the face. The timeline of the patient's paronychia and acneiform rash were consistent with a diagnosis of neratinib-associated skin changes. The patient was prescribed doxycycline to control the acneiform eruption. For t...
Source: Journal of Dermatological Treatment - October 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The emerging role of skin microbiome in atopic dermatitis and its clinical implication.
Authors: Stalder JF, Fluhr JW, Foster T, Glatz M, Proksch E Abstract In recent years, the importance of the microbiome in maintaining healthy skin has become apparent. Both the classic microbiology cultivation techniques used since the early 1970s and the next-generation sequencing procedures refined in the past decade reveal the importance of skin microbiome in healthy and diseased skin. To strengthen and eventually restore a healthy microbiome in patients with dermatological conditions like atopic dermatitis (AD), it is important to consider the factors that influence the composition of the microbiome, such as sk...
Source: Journal of Dermatological Treatment - October 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Real-world experience of calcipotriene and betamethasone dipropionate foam 0.005%/0.064% in the treatment of adults with psoriasis in the United States.
CONCLUSION: Data from real clinical practice demonstrate that Cal/BD foam improves psoriasis disease severity and associated itch in patients and further extend results of clinical trials. PMID: 30307343 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 13, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Safety and effectiveness of conventional systemic therapy and biological drugs in patients with moderate to severe psoriasis and HIV infection: a retrospective multicenter study.
CONCLUSION: Biologic drugs, both anti-TNF alpha agents and ustekinumab, seem to have an acceptable safety profile and high effectiveness in HIV-positive patients. PMID: 30307344 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 13, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evidence of metabolic imbalance and oxidative stress among patients suffering from pressure ulcers.
CONCLUSION: Understanding the signaling pathways involved in the development of PU will provide experts with additional knowledge for therapeutic strategies aimed at limiting the oxidative and inflammatory reactions in affected patients. PMID: 30300033 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 11, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Caregiver Willingness to Treat Atopic Dermatitis is Not Much Improved by Anchoring.
CONCLUSIONS: Caregivers reported being generally quite willing to apply topical corticosteroids once-daily. Anchoring was associated with a slightly higher score, though it was not statistically significant. For most patients with atopic dermatitis, anchoring may not be helpful, but for patients whose main barrier is perceived burdensomeness of treatment, anchoring may be of some benefit. PMID: 30277424 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 4, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Neonatal epidermolysis bullosa: Lessons to learn about genetic counselling.
We describe genetics of neonatal EB in Hong Kong. Two neonates of consanguineous Pakistani parents had the EB-Pyloric Atresia (EB-PA) variant. One had a 4 kb homozygous deletion of exon 19-25 of the ITGB4 gene, and the other with only a histopathological diagnosis. Both died of sepsis in infancy. Aberrant COL7A1 mutations in the dominant and recessive EB were described. Genetic analysis, together with histopathological classification is important to aid prognosis and counselling. JEB and EB-PA are associated with consanguinity and mortality during infancy. Morbidity and prognosis of the autosomal dominant DEB is opt...
Source: Journal of Dermatological Treatment - October 4, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

An evaluation of intensity of delusional belief in patients with delusional infestation pre- and post-treatment in a specialist psychodermatology centre.
Authors: Gkini MA, Nogueira J, Tanev T, Mohandas P, Taylor R, Bewley A Abstract INTRODUCTION: The majority of patients with delusional infestation (DI) seek help from dermatologists as they consider their condition to be of cutaneous origin and deny referral to psychiatrists, with the prevalence of the condition arising. Objectives of our study were:1.to assess whether there is a fixed delusional ideation in patients with DI, 2. to assess the efficacy of managing such patients with combined dermatological and psychiatric treatment and 3.to test any correlation between BABS scores and other variables. METHODS: A...
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Atopic Dermatitis Spectrum Disorder: new conceptualization for the coming new therapeutic era.
Authors: Butler D, Koo J PMID: 30270771 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Scalp psoriasis: report of efficient treatment with secukinumab.
Authors: Pistone G, Tilotta G, Gurreri R, Curiale S, Bongiorno MR Abstract Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the population in the world. The scalp is the most common, and frequently the first site of disease involvement. Occasionally it may be the only localization of psoriasis. Treatment of scalp psoriasis is often unsatisfactory, due to limited available topical therapy and reduced efficacy of some systemic drugs. Biologic therapies are recommended for severe psoriasis, resistant to topical treatment, but evidence from randomized, controlled studies is lacking regarding effective...
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Sunscreen Application to the Face Persists Beyond 2  Hours in Indoor Workers: An Open Label Trial.
Conclusion: For indoor workers who applied adequate amount of sunscreen once in the morning, reapplication of sunscreen may be unnecessary. PMID: 30273065 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Candida infections in psoriatic patients on anti-IL17 therapy: a case series.
We report the occurrence of those infections in psoriatic patients receiving secukinumab 300 mg. Sixteen patients, treated with secukinumab 300 mg, for one year, and documented by mycological examinations, did not present any increase in the occurrence of Candida spp. infection, even asymptomatic. Moreover, 2 patients, after secukinumab treatment, became negative for candida detection, without any additional anti-fungal therapy. Although this case series is limited in size, our results may be reassuring on the low risk of candida infection in psoriatic patients, during secukinumab therapy. PMID: 30273067 ...
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab efficacy in the treatment of nail psoriasis: a case series.
Authors: Pistone G, Gurreri R, Tilotta G, Castelli E, Bongiorno MR Abstract Nail involvement is frequent in patients with psoriasis, especially those with psoriatic arthritis, and can significantly impair quality of life. It is typically difficult to treat compared with skin lesions, although several conventional treatment options are available. The aim of this paper is to describe our experience in the treatment of nail psoriasis with secukinumab in a case series. Fifteen patients (11 males and 4 females), with moderate-severe plaque psoriasis and nail psoriasis, eligible for systemic therapy, received secukinumab...
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of Adalimumab after failure of other anti-TNF α agents for plaque-type psoriasis: clinician behaviour in real life clinical practice.
CONCLUSION: Adalimumab profile was excellent in this 5-years retrospective observation, showing the clinical validity of interclass transitioning among anti-TNFα options. PMID: 30273075 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 3, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Effects of Amniotic Membrane Stem Cell-Conditioned Medium on Photoaging.
Authors: Prakoeswa CRS, Pratiwi FD, Herwanto N, Citrashanty I, Indramaya DM, Murtiastutik D, Sukanto H, Rantam FA Abstract BACKGROUND: Photoaging is a complex biologic process that affects various layers of the skin with the major damage seen in the connective tissue of the dermis. Although rarely fatal, photoaging can significantly contribute to a loss of quality of life; therefore, it deserves attention. Researchers are continually searching for new compounds to develop rejuvenation therapies. Nowadays, the stem cell population has been discovered, and it shows capability to rejuvenate the skin. MATERIAL AND ...
Source: Journal of Dermatological Treatment - September 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Pharmacokinetic disposition of topical phosphodiesterase-4 inhibitor E6005 in patients with atopic dermatitis.
CONCLUSION: Exposure to topical E6005 is associated with the eczema-associated area, however, that is not distinctly associated with its adverse drug reactions occurred after drug applications possibly due to E6005's characteristics of tissue distribution. PMID: 30265585 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - September 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Skin substitutes for acute and chronic wound healing: an updated review.
CONCLUSION: Our model of skin substitutes was organized based on the different layers of cutaneous involvement and the origin of the product material. We believe that this framework provides a practical guide for selection of the most appropriate skin substitute based on clinical indication. PMID: 30265595 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - September 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effective treatment with omalizumab of a patient with spontaneous chronic urticaria and eosinophilic esophagitis.
This article reports the clinical history of a patient who had been affected by chronic spontaneous urticaria for 13 years, resistant to currently recommended therapy, and who was also diagnosed eosinophilic esophagitis. The anti-IgE monoclonal antibody omalizumab was rapidly effective and induced the clinical remission of both diseases. PMID: 30265608 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - September 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Social media in dermatology: clinical relevance, academic value, and trends across platforms.
Authors: DeBord LC, Patel V, Braun TL, Dao H Abstract Social media encompasses multiple sites for online communication that reach a large proportion of the global population. While the increase in number of publications investigating dermatology content on social media has paralleled the growth of social media in the past decade, there has not yet been an extensive review of past literature on this topic. Our objective is to summarize and analyze publications on the role of social media within the field of dermatology. Social media is frequently used by patients to solicit advice related to cutaneous concerns and e...
Source: Journal of Dermatological Treatment - September 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Wedelolactone suppresses cell proliferation and migration through Akt and AMPK signaling in melanoma.
CONCLUSION: Wedelolactone suppressed cell proliferation and regulated MV3 cell cycle proteins through AKT and AMPK signaling in melanoma. PMID: 30252545 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - September 27, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo.
CONCLUSION: This study concluded that suction blistering technique is more effective and safe than mini punch technique and hair follicle technique in treatment of stable vitiligo. PMID: 30252548 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - September 27, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research