Journal of Cardiovascular Translational Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy
This study aimed to assess the effect of canagliflozin (CAN) on atherogenesis via autophagy. Macrophages and ApoE − / − mice were used in this study. In macrophages, the results showed that CAN promoted LC3II expression and autophagosome formation. Furthermore, the cholesterol efflux assay demonstrated that CAN enhanced cholesterol efflux from macrophages via autophagy, resulting in lower lipid dro plet concentrations in macrophages. The western blot revealed that CAN regulated autophagy via the AMPK/ULK1/Beclin1 signaling pathway. CAN resulted in increased macrophage autophagy in atherosclerotic plaques of Ap...
Source: Journal of Cardiovascular Translational Research - May 1, 2023 Category: Cardiology Source Type: research

Profiling the Biomechanical Responses to Workload on the Human Myocyte to Explore the Concept of Myocardial Fatigue and Reversibility: Rationale and Design of the POWER Heart Failure Study
AbstractIt remains unclear why some patients develop heart failure without evidence of structural damage. One theory relates to impaired myocardial energetics and ventricular-arterial decoupling as the heart works against adverse mechanical load. In this original study, we propose the novel concept of myocardial fatigue to capture this phenomenon and aim to investigate this using human cardiomyocytes subjected to a modern work-loop contractility model that closely mimics in vivo cardiac cycles. This proof-of-concept study (NCT04899635) will use human myocardial tissue samples from patients undergoing cardiac surgery to ...
Source: Journal of Cardiovascular Translational Research - May 1, 2023 Category: Cardiology Source Type: research

Isolated Coronary Arteritis in Adults: a Single-Center Experience from China
AbstractIsolated coronary arteritis (ICA) is an extremely rare and life-threatening vasculitis with only a limited number of reports in the literature. We retrospectively reviewed the clinical data of 10 ICA patients in our center from 2012 to 2022 and compared them with patients with Takayasu arteritis who presented with coronary arteritis initially (TAK-CA patients). We found that ICA predominantly affected women and most commonly involved the ostium and the proximal segment of the coronary arteries, causing mainly stenotic lesions. The C-reactive protein and erythrocyte sedimentation rate were grossly normal and signifi...
Source: Journal of Cardiovascular Translational Research - April 25, 2023 Category: Cardiology Source Type: research

Coronary Perfusion After Valve-in-Valve Transcatheter Aortic Valve Implantation in Small Aortic Root: In Vitro Experimental Assessment
AbstractCoronary flow obstruction following transcatheter aortic valve-in-valve implantation (VIV-TAVI) is associated with a high mortality risk. The aim of this work was to quantify the coronary perfusion after VIV-TAVI in a high-risk aortic root anatomy. 3D printed models of small aortic root were used to simulate the implantation of a TAVI prosthesis (Portico 23) into surgical prostheses (Trifecta 19 and 21). The aortic root models were tested in a pulsatile in vitro bench setup with a coronary perfusion simulator. The tests were performed at baseline and post-VIV-TAVI procedure in aligned and misaligned commissural con...
Source: Journal of Cardiovascular Translational Research - April 25, 2023 Category: Cardiology Source Type: research

Hif-1 α/Slit2 Mediates Vascular Smooth Muscle Cell Phenotypic Changes in Restenosis of Bypass Grafts
This study aimed to explore the role of Slit2 in phenotypic switching of VSMCs and its effect on restenosis of vascular conduits. An animal model of vascular graft restenosis (VGR) was produced in SD rats and assessed by echocardiography. The expression of Slit2 and Hif-1 α was measured in vivo and in vitro. After Slit2 overexpression, the migration and proliferation of VSMCs were detected in vitro, and the restenosis rates and phenotype of VSMCs were tested in vivo. The arteries of the VGR model presented significant stenosis, and Slit2 was decreased in VSMCs of th e VGR model. In vitro, Slit2 overexpression inhibited th...
Source: Journal of Cardiovascular Translational Research - April 25, 2023 Category: Cardiology Source Type: research

Reply to “The Predictive Role of Glycocalyx Assessment in Subjects with Cardiovascular Risk Factors Within and Beyond SCORE”
(Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - April 25, 2023 Category: Cardiology Source Type: research

Biomarkers of Endothelial Glycocalyx Integrity for Cardiovascular Events in Individuals Without Cardiovascular Disease
(Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - April 14, 2023 Category: Cardiology Source Type: research

Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
AbstractSodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering blood glucose levels effectively via increasing the glomerular excretion of glucose. A good number of randomized clinical trials revealed that SGLT2is significantly prevented heart failure (HF) and cardiovascular death in T2DM patients. Despite ongoing clinical trials in HF patients without T2DM, there have been a limited number of translational studies on the cardioprotective properties of SGLT2is. ...
Source: Journal of Cardiovascular Translational Research - April 13, 2023 Category: Cardiology Source Type: research

Heart Failure with Preserved vs. Reduced Ejection Fraction: Patient Characteristics, In-hospital Treatment and Mortality —DanAHF, a Nationwide Prospective Study
This study aims to describe baseline characteristics and in-hospital management of a patient cohort hospitalized with acute heart failure (AHF). Adult patients in Denmark admitted with a medical diagnosis during a 7-day period were reviewed for symptoms and clinical findings suggestive of AHF. HFpEF was defined as LVEF ≥ 45%. Of 5194 patients, 290 (6%) had AHF. Sixty-two percent (n = 179) was diagnosed with HFpEF. Compared to HFrEF patients, HFpEF patients were more often women (48% vs. 31%,p = 0.004), less likely to have ischemic heart disease (31% vs. 53%,p = 0.002) and a pacemaker/ICD (7% vs. 21%,p ...
Source: Journal of Cardiovascular Translational Research - April 13, 2023 Category: Cardiology Source Type: research