Journal of Cardiovascular Translational Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cardiac Fibroblast Activation Induced by Oxygen –Glucose Deprivation Depends on the HIF-1α/miR-212-5p/KLF4 Pathway
This study aimed to identify a new pathway of miR-212-5p in the activation of human cardiac fibroblasts (HCFs) induced by oxygen –glucose deprivation (OGD). First, we found that KLF4 protein was markedly decreased in OGD-induced HCFs. Then, bioinformatics analysis and verification experiments were used to identify the existence of an interaction of KLF4 with miR-212-5p. Functional experiments indicated that OGD significantl y upregulated the expression of hypoxia inducible factor-1 alpha (HIF-1 α) in HCFs, which positively regulated miR-212-5p transcription by binding to its promoter. MiR-212-5p inhibited the expression...
Source: Journal of Cardiovascular Translational Research - June 7, 2023 Category: Cardiology Source Type: research

Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives
AbstractIschemic cardiomyopathy is treated mainly with thrombolytic drugs, percutaneous coronary intervention, and coronary artery bypass grafting to recanalize blocked vessels. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable complication of obstructive revascularization. Compared with those of myocardial ischemic injury, few effective therapeutic options are available for MIRI treatment. The pathophysiological mechanisms of MIRI involve the inflammatory response, the immune response, oxidative stress, apoptosis, intracellular Ca2+ overload, and cardiomyocyte energy metabolism. These mechanisms exacerbate M...
Source: Journal of Cardiovascular Translational Research - June 7, 2023 Category: Cardiology Source Type: research

Circulating Acylcarnitines Associated with Hypertrophic Cardiomyopathy Severity: an Exploratory Cross-Sectional Study in MYBPC3 Founder Variant Carriers
AbstractHypertrophic cardiomyopathy (HCM) is a relatively common genetic heart disease characterised by myocardial hypertrophy. HCM can cause outflow tract obstruction, sudden cardiac death and heart failure, but severity is highly variable. In this exploratory cross-sectional study, circulating acylcarnitines were assessed as potential biomarkers in 124MYBPC3 founder variant carriers (59 with severe HCM, 26 with mild HCM and 39 phenotype-negative [G + P-]). Elastic net logistic regression identified eight acylcarnitines associated with HCM severity. C3, C4, C6-DC, C8:1, C16, C18 and C18:2 were significantly increased...
Source: Journal of Cardiovascular Translational Research - June 6, 2023 Category: Cardiology Source Type: research

Imaging Real-Time Coronary Anatomy Using a Three-Dimensional Electrophysiology Mapping System
AbstractThe aim of this study is to evaluate the feasibility of creating fast three-dimensional maps of coronary arteries and to develop a bipolar coronary guidewire in vitro and determine whether it can be localised accurately within the model.A total of five patients were recruited, and EnSite Precision was utilised to create 3D coronary anatomy. A water bath to accommodate a 3D-printed coronary model was developed to test the performance of the bipolar angioplasty wire.Successful guidewire localisation and 3D reconstruction of coronary anatomy were achieved in all the cases. No complications. The bipolar wire was able t...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Machine Learning Identification Framework of Hemodynamics of Blood Flow in Patient-Specific Coronary Arteries with Abnormality
In this study, we put forth a new deep neural network framework to predict flow behavior in a coronary arterial network with different properties in the presence of any abnormality like stenosis. An artificial neural network (ANN) model is trained using synthetic data so that it can predict the pressure and velocity within the arterial network. The data required to train the neural network were obtained from the CFD analysis of several geometries of arteries with specific features in ABAQUS software. The proposed approach precisely predicts the hemodynamic behavior of the blood flow. The average accuracy of the pressure pr...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Correction to: Systemic Inflammatory Burden Correlates with Severity and Predicts Outcomes in Patients with Cardiogenic Shock Supported by a Percutaneous Mechanical Assist Device
(Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Design and Rationale of the BIOFLOW-DAPT Trial: a Prospective, Randomized, Multicenter Study to Assess the Safety of the Orsiro Mission Stent Compared to the Resolute Onyx Stent in Subjects at High Risk for Bleeding in Combination with 1-Month Dual Antiplatelet Therapy
AbstractThe optimal duration of dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients undergoing percutaneous coronary intervention (PCI) with implantation of the Orsiro Mission stent remains unclear. The BIOFLOW-DAPT (clinicaltrials.gov, NCT04137510) trial is a prospective, multi-center, randomized controlled study designed to assess the safety of the Orsiro Mission versus the Resolute Onyx stent in HBR patients. Patients are treated with DAPT (aspirin and a P2Y12 inhibitor) for 1 month, followed by a single antiplatelet therapy (SAPT). The primary endpoint is the composite of cardiac death, myocardial i...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring —an In Vitro Evaluation
AbstractAn increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

NR4A1 Aggravates Myocardial Ischaemia –Reperfusion Injury by Inhibiting OPA1-Mediated Mitochondrial Fusion
In conclusion, NR4A1 can exacerbate IR by inhibiting OPA1, causing mitochondrial damage.Graphical abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - May 30, 2023 Category: Cardiology Source Type: research