Journal of Cardiovascular Translational Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

CAV1 Protein Encapsulated in Mouse BMSC-Derived Extracellular Vesicles Alleviates Myocardial Fibrosis Following Myocardial Infarction by Blocking the TGF- β1/SMAD2/c-JUN Axis
In conclusion, mBMSC-EVs mitigate myocardial fibrosis in MI mice by delivering the CAV1 protein, inhibiting the TGF-β1/SMAD2/c-JUN pathway.Graphical AbstractMolecular mechanism of mBMSC-EVs-CAV1-mediated TGF- β1/SMAD2/c-JUN axis in inhibiting cardiac fibroblast differentiation to improve MF after MI. mBMSC-EVs deliver CAV1 protein to CFs where the protein expression of CAV1 is upregulated upon hypoxia conditions. The TGF-β1/SMAD2 signaling pathway downstream of CAV1 is consequently inactivated, the tra nscription of c-JUN is inhibited, and transcription of SMAD2/c-JUN transcription complex target genes α-SMA and Collag...
Source: Journal of Cardiovascular Translational Research - December 13, 2023 Category: Cardiology Source Type: research

Diabetes Mellitus to Accelerated Atherosclerosis: Shared Cellular and Molecular Mechanisms in Glucose and Lipid Metabolism
AbstractDiabetes is one of the critical independent risk factors for the progression of cardiovascular disease, and the underlying mechanism regarding this association remains poorly understood. Hence, it is urgent to decipher the fundamental pathophysiology and consequently provide new insights into the identification of innovative therapeutic targets for diabetic atherosclerosis. It is now appreciated that different cell types are heavily involved in the progress of diabetic atherosclerosis, including endothelial cells, macrophages, vascular smooth muscle cells, dependence on altered metabolic pathways, intracellular lip...
Source: Journal of Cardiovascular Translational Research - December 13, 2023 Category: Cardiology Source Type: research

ALK1 Deficiency Impairs the Wound-Healing Process and Increases Mortality in Murine Model of Myocardial Infarction
AbstractThe functional role of TGF β type I receptor, activin-like kinase (ALK)-1 in post-myocardial infarction (MI) cardiac remodeling is unknown. We hypothesize that reduced ALK1 activity reduces survival and promotes cardiac fibrosis after MI. MI was induced in wild-type (WT), and ALK+/ − mice by left coronary ligation. After 14 days ALK1+/ − mice had reduced survival with a higher rate of cardiac rupture compared to WT mice. ALK1+/ − left ventricles (LVs) had increased volumes at the end of systole and at the end of diastole. After MI ALK1+/ − LVs had increased profibrotic SMAD3 signaling, type 1 collagen, and...
Source: Journal of Cardiovascular Translational Research - December 8, 2023 Category: Cardiology Source Type: research

Correction: New Insights into the Genetics of Cardiomyopathies
(Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - December 8, 2023 Category: Cardiology Source Type: research

T-cell Immunoglobulin and Mucin Domain 3 in Circulating Monocytes as a Novel Biomarker for Coronary Artery Disease
In conclusion, Tim-3 in circulating monocytes is a novel biomarker for CAD.Graphical AbstractT-cell immunoglobulin and mucin domain 3 (Tim-3) in circulating monocytes as a novel biomarker for coronary artery disease. (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - December 7, 2023 Category: Cardiology Source Type: research

RNA Sequencing of Whole Blood in Premature Coronary Artery Disease: Identification of Novel Biomarkers and Involvement of T Cell Imbalance
AbstractSerum biomarkers were explored based on the peripheral blood gene expression profiles of premature coronary artery disease (PCAD). RNA sequencing (RNA-Seq) was used to detect PCAD-specific differentially expressed genes (DEGs). Quantitative real-time polymerase chain reaction (RT-PCR) was used to validate the most significant DEGs, and enzyme-linked immunosorbent assay (ELISA) was utilized to quantify the effect on corresponding serum proteins. Fifty-nine PCAD-specific DEGs were identified. Functional analysis showed positive regulation of T cell-mediated cytotoxicity, regulation of T cell-mediated immunity, and th...
Source: Journal of Cardiovascular Translational Research - December 1, 2023 Category: Cardiology Source Type: research

The Trouble with Trabeculation: How Genetics Can Help to Unravel a Complex and Controversial Phenotype
AbstractExcessive trabeculation of the cardiac left ventricular wall is a complex phenotypic substrate associated with various physiological and pathological processes. There has been considerable conjecture as to whether hypertrabeculation contributes to disease and whether left ventricular non-compaction (LVNC) cardiomyopathy is a distinct pathology. Building on recent insights into the genetic basis of LVNC cardiomyopathy, in particular three meta-analysis studies exploring genotype –phenotype associations using different methodologies, this review examines how genetic research can advance our understanding of trabecu...
Source: Journal of Cardiovascular Translational Research - November 29, 2023 Category: Cardiology Source Type: research

New Insights into the Genetics of Cardiomyopathies
(Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - November 28, 2023 Category: Cardiology Source Type: research

Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development
AbstractAtherosclerosis is a chronic inflammatory disease that is the underlying cause of cardiovascular disease which initiates from endothelial dysfunction from genetic and environmental risk factors, including biomechanical forces: blood flow. Endothelial cells (ECs) lining the inner arterial wall regions exposed to disturbed flow are prone to atherosclerosis development, whereas the straight regions exposed to stable flow are spared from the disease. These flow patterns induce genome- and epigenome-wide changes in gene expression in ECs. Through the sweeping changes in gene expression, disturbed flow reprograms ECs fro...
Source: Journal of Cardiovascular Translational Research - November 27, 2023 Category: Cardiology Source Type: research