Imaging Real-Time Coronary Anatomy Using a Three-Dimensional Electrophysiology Mapping System
AbstractThe aim of this study is to evaluate the feasibility of creating fast three-dimensional maps of coronary arteries and to develop a bipolar coronary guidewire in vitro and determine whether it can be localised accurately within the model.A total of five patients were recruited, and EnSite Precision was utilised to create 3D coronary anatomy. A water bath to accommodate a 3D-printed coronary model was developed to test the performance of the bipolar angioplasty wire.Successful guidewire localisation and 3D reconstruction of coronary anatomy were achieved in all the cases. No complications. The bipolar wire was able t...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Machine Learning Identification Framework of Hemodynamics of Blood Flow in Patient-Specific Coronary Arteries with Abnormality
In this study, we put forth a new deep neural network framework to predict flow behavior in a coronary arterial network with different properties in the presence of any abnormality like stenosis. An artificial neural network (ANN) model is trained using synthetic data so that it can predict the pressure and velocity within the arterial network. The data required to train the neural network were obtained from the CFD analysis of several geometries of arteries with specific features in ABAQUS software. The proposed approach precisely predicts the hemodynamic behavior of the blood flow. The average accuracy of the pressure pr...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Correction to: Systemic Inflammatory Burden Correlates with Severity and Predicts Outcomes in Patients with Cardiogenic Shock Supported by a Percutaneous Mechanical Assist Device
(Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Design and Rationale of the BIOFLOW-DAPT Trial: a Prospective, Randomized, Multicenter Study to Assess the Safety of the Orsiro Mission Stent Compared to the Resolute Onyx Stent in Subjects at High Risk for Bleeding in Combination with 1-Month Dual Antiplatelet Therapy
AbstractThe optimal duration of dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients undergoing percutaneous coronary intervention (PCI) with implantation of the Orsiro Mission stent remains unclear. The BIOFLOW-DAPT (clinicaltrials.gov, NCT04137510) trial is a prospective, multi-center, randomized controlled study designed to assess the safety of the Orsiro Mission versus the Resolute Onyx stent in HBR patients. Patients are treated with DAPT (aspirin and a P2Y12 inhibitor) for 1  month, followed by a single antiplatelet therapy (SAPT). The primary endpoint is the composite of cardiac death, myocardial i...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring —an In Vitro Evaluation
AbstractAn increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Design and Rationale of the BIOFLOW-DAPT Trial: a Prospective, Randomized, Multicenter Study to Assess the Safety of the Orsiro Mission Stent Compared to the Resolute Onyx Stent in Subjects at High Risk for Bleeding in Combination with 1-Month Dual Antiplatelet Therapy
AbstractThe optimal duration of dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients undergoing percutaneous coronary intervention (PCI) with implantation of the Orsiro Mission stent remains unclear. The BIOFLOW-DAPT (clinicaltrials.gov, NCT04137510) trial is a prospective, multi-center, randomized controlled study designed to assess the safety of the Orsiro Mission versus the Resolute Onyx stent in HBR patients. Patients are treated with DAPT (aspirin and a P2Y12 inhibitor) for 1  month, followed by a single antiplatelet therapy (SAPT). The primary endpoint is the composite of cardiac death, myocardial i...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

Novel Expansible Aortic Annuloplasty Ring Exhibits Similar Characteristics as the Dacron Ring —an In Vitro Evaluation
AbstractAn increasing body of research indicates that annular stability plays a key role for a successful aortic valve repair. The aim of this study was to evaluate and compare a novel open aortic annuloplasty ring (the A-ring) with the Dacron ring. Both rings were compared with native aortic roots in vitro. Eighteen aortic roots were included in the study and randomized into three groups: the native, Dacron, and A-ring group. The roots were evaluated in an in vitro physiologic pulsatile model simulating the left side of the heart. Aortic annulus diameters were significantly reduced both in the Dacron ring group (p = 0...
Source: Journal of Cardiovascular Translational Research - June 1, 2023 Category: Cardiology Source Type: research

NR4A1 Aggravates Myocardial Ischaemia –Reperfusion Injury by Inhibiting OPA1-Mediated Mitochondrial Fusion
In conclusion, NR4A1 can exacerbate IR by inhibiting OPA1, causing mitochondrial damage.Graphical abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - May 30, 2023 Category: Cardiology Source Type: research

Evaluation of a Rabbit Model of Vascular Stent Healing: Application of Optical Coherence Tomography
AbstractPercutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). Despite advancements, in-stent restenosis (ISR) still imparts a 1 –2% annual rate of repeat revascularization—a focus of ongoing translational research. Optical coherence tomography (OCT) provides high resolution virtual histology of stents. Our study evaluates the use of OCT for virtual histological assessment of stent healing in a rabbit aorta model, enablin g complete assessment of intraluminal healing throughout the stent. ISR varies based on intra-stent location, stent length, and st...
Source: Journal of Cardiovascular Translational Research - May 25, 2023 Category: Cardiology Source Type: research

Evaluation of a New Aptamer-Based Array for Soluble Suppressor of Tumorgenicity (ST2) and N-terminal Pro-B-Type Natriuretic Peptide (NTproBNP) in Heart Failure Patients
ConclusionSOMAscan quantifications of ST2 and NTproBNP correlate to ELISA versions and carry similar prognosis.Graphical abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - May 16, 2023 Category: Cardiology Source Type: research

Augmenting Prediction of Intracranial Aneurysms ’ Risk Status Using Velocity-Informatics: Initial Experience
AbstractOur primary goal here is to demonstrate that innovative analytics of aneurismal velocities, named velocity-informatics, enhances intracranial aneurysm (IA) rupture status prediction. 3D computer models were generated using imaging data from 112 subjects harboring anterior IAs (4 –25 mm; 44 ruptured and 68 unruptured). Computational fluid dynamics simulations and geometrical analyses were performed. Then, computed 3D velocity vector fields within the IA dome were processed for velocity-informatics. Four machine learning methods (support vector machine, random forest, gene ralized linear model, and GLM with Lasso ...
Source: Journal of Cardiovascular Translational Research - May 9, 2023 Category: Cardiology Source Type: research