3D Finite Element Models Reconstructed From 2D Dual ‐Energy X‐Ray Absorptiometry (DXA) Images Improve Hip Fracture Prediction Compared to Areal BMD in Osteoporotic Fractures in Men (MrOS) Sweden Cohort
ABSTRACTBone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction tools. 3D finite element (FE) models predict bone strength better than aBMD, but their clinical use is limited by the need for 3D computed tomography and lack of automation. We have earlier developed a method to reconstruct the 3D hip anatomy from a 2D DXA image, followed by subject-specific FE-based prediction of proximal femoral strength. In the current study, we aim to evaluate the method's ability to...
Source: Journal of Bone and Mineral Research - August 8, 2023 Category: Orthopaedics Authors: Lorenzo Grassi, Sami P. V äänänen, Lars Jehpsson, Östen Ljunggren, Björn E. Rosengren, Magnus K. Karlsson, Hanna Isaksson Tags: Research Article Source Type: research

Effect of Race/Ethnicity on United States FRAX Calculations and Treatment Qualification: A Registry ‐Based Study
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 7, 2023 Category: Orthopaedics Authors: William D. Leslie, For the ASBMR Task Force on Clinical Algorithms for Fracture Risk Tags: Research Article Source Type: research

Buds of new bone formation within the femoral head of hip fracture patients coincide with zones of low osteocyte sclerostin
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 7, 2023 Category: Orthopaedics Authors: Hiroshige Sano, Tristan Whitmarsh, Linda Skingle, Taketoshi Shimakura, Noriaki Yamamoto, Juliet E. Compston, Hideaki E. Takahashi, Kenneth E. S. Poole Tags: Research Article Source Type: research

A risk assessment tool for predicting fragility fractures in people with HIV: derivation and internal validation of the FRESIA model
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 7, 2023 Category: Orthopaedics Authors: Pilar Vizcarra, Ana Moreno, Mar ía J. Vivancos, Alfonso Muriel García, Margarita Ramirez Schacke, Juan González‐Garcia, Adrián Curran, Rosario Palacios, Antonio Jesús Sánchez Guirao, Sergio Reus Bañuls, Santiago Moreno Guillén, José Tags: Research Article Source Type: research

GSTT1 as a predictive marker and enhancer for osteogenic potential of human adipose ‐derived stromal/stem cells
In conclusion, GSTT1 can be a useful marker to screen the highly osteogenic ASC clones and also a therapeutic factor to enhance the osteogenic differentiation of poorly osteogenic ASC clones.This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 4, 2023 Category: Orthopaedics Authors: Eugene Lee, Jae ‐Yeon Moon, Ji‐Yun Ko, Seo‐Young Park, Gun‐Il Im Tags: Research Article Source Type: research

No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women
ABSTRACTBisphosphonates are widely used for the prevention and treatment of osteoporosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also widely used among the older population group at high risk of fractures. NSAIDs have been shown to impact on bone turnover, and a recent reanalysis of a clinical trial of clodronate found that NSAID use at baseline abrogated any effect of clodronate on either bone density (BMD) or fracture risk. To determine whether NSAIDs influence the efficacy of other bisphosphonates, we have reanalyzed our 6-year randomized controlled trial of zoledronate in 2000 osteopenic postmenopausal women...
Source: Journal of Bone and Mineral Research - August 3, 2023 Category: Orthopaedics Authors: Ian R Reid, Anne M Horne, Borislav Mihov, Sonja Bastin, Gregory D Gamble Tags: Research Article Source Type: research

Periprosthetic Joint Infections of the Knee Lastingly Impact the Bone Homeostasis
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 3, 2023 Category: Orthopaedics Authors: Evgeniya Bandick, Lara Biedermann, Yi Ren, Stefanie Donner, Mario Thiele, Gabriela Korus, Serafeim Tsitsilonis, Michael M üller, Georg Duda, Carsten Perka, Arne Kienzle Tags: Research Article Source Type: research

No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women
ABSTRACTBisphosphonates are widely used for the prevention and treatment of osteoporosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also widely used among the older population group at high risk of fractures. NSAIDs have been shown to impact on bone turnover, and a recent reanalysis of a clinical trial of clodronate found that NSAID use at baseline abrogated any effect of clodronate on either bone density (BMD) or fracture risk. To determine whether NSAIDs influence the efficacy of other bisphosphonates, we have reanalyzed our 6-year randomized controlled trial of zoledronate in 2000 osteopenic postmenopausal women...
Source: Journal of Bone and Mineral Research - August 3, 2023 Category: Orthopaedics Authors: Ian R Reid, Anne M Horne, Borislav Mihov, Sonja Bastin, Gregory D Gamble Tags: Research Article Source Type: research

Vitamin D metabolites are associated with musculoskeletal injury in young adults: a prospective cohort study
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 2, 2023 Category: Orthopaedics Authors: Alexander T. Carswell, Thomas J. O'Leary, Paul Swinton, Sarah Jackson, Jonathan C. Y. Tang, Samuel J. Oliver, Rachel M. Izard, Neil P. Walsh, William D. Fraser, Julie P. Greeves Tags: Research Article Source Type: research