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Active Vitamin D Use and Fractures in Hemodialysis Patients: Results from the International DOPPS
ABSTRACTActive vitamin D is commonly used to control secondary hyperparathyroidism in dialysis patients, but it is unknown whether active vitamin D directly improves bone strength, independently of its ability to suppress parathyroid hormone (PTH). We analyzed the association between the prescription of active vitamin D and incidence of any fracture and hip fracture in 41,677 in-center hemodialysis patients from 21 countries in phases 3 to 6 (2005 to 2018) of the Dialysis Outcomes and Practice Patterns Study (DOPPS). We used Cox regression, adjusted for PTH and other potential confounders, and used a per-protocol approach ...
Source: Journal of Bone and Mineral Research - September 30, 2023 Category: Orthopaedics Authors: Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce M. Robinson, Masafumi Fukagawa Tags: Research Article Source Type: research

Breathing Easy for Better Bones: The Undervalued Role of Air Quality in Bone Health
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - September 30, 2023 Category: Orthopaedics Authors: Andrea A. Baccarelli, Diddier Prada Tags: Editorial Source Type: research

Cannabidiol and Cannabigerol, Nonpsychotropic Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and Promote Healing in Mice
ABSTRACTBone fractures are among the most prevalent musculoskeletal injuries, and pain management is an essential part of fracture treatment. Fractures heal through an early inflammatory phase, followed by repair and remodeling. Nonsteroidal anti-inflammatory drugs (NSAIDs) are not recommended for fracture pain control as they potently inhibit the inflammatory phase and, thus, impair the healing. Opioids do not provide a better alternative for several reasons, including abuse potential. Accordingly, there is an unmet clinical need for analgesics that effectively ameliorate postfracture pain without impeding the healing. He...
Source: Journal of Bone and Mineral Research - September 26, 2023 Category: Orthopaedics Authors: Deepak Kumar Khajuria, Vengadeshprabhu Karuppagounder, Irena Nowak, Diana E. Sepulveda, Gregory S. Lewis, Christopher C. Norbury, Wesley M. Raup ‐Konsavage, Kent E. Vrana, Fadia Kamal, Reyad A. Elbarbary Tags: Research Article Source Type: research

Towards improved identification of vertebral fractures in routine CT scans: development and external validation of a machine learning algorithm
Vertebral fractures are the landmark of osteoporosis and are associated with increased risk of further fractures. Yet they commonly go undiagnosed, and the underlying osteoporosis untreated. We developed a machine learning algorithm for automated vertebral fracture detection and demonstrated strong performance on an external validation set of 2,000 CT scans. This method can improve the identification and reporting of vertebral fractures by opportunistically screening for them in routine CT scans. ABSTRACTVertebral fractures (VFs) are the hallmark of osteoporosis, being one of the most frequent types of fragility fracture a...
Source: Journal of Bone and Mineral Research - September 25, 2023 Category: Orthopaedics Authors: Joeri Nicolaes, Michael Kriegbaum Skj ødt, Steven Raeymaeckers, Christopher Dyer Smith, Bo Abrahamsen, Thomas Fuerst, Marc Debois, Dirk Vandermeulen, Cesar Libanati Tags: Research Article Source Type: research

Electrocardiogram Changes Following Intravenous Bisphosphonate Infusion: A Systematic Review and Meta ‐Analysis
ABSTRACTBisphosphonates are first-line treatments for several bone and mineral disorders. Studies have reported an increased incidence of serious atrial fibrillation in patients receiving bisphosphonates; however, uncertainty remains as to whether electrical disturbances are precipitated by bisphosphonates. We aimed to review the literature for studies reporting electrocardiogram (ECG) findings in patients receiving intravenous bisphosphonates for any indication. We searched MEDLINE and EMBASE from inception until January 14, 2023, for studies reporting ECG parameters after intravenous bisphosphonate infusion. We excluded ...
Source: Journal of Bone and Mineral Research - September 25, 2023 Category: Orthopaedics Authors: Alex Shoung, Nicholas Shoung, Rachael Hii, Nitesh Nerlekar, Peter R Ebeling, Alexander J Rodr íguez Tags: Research Article Source Type: research

VEGF Secretion Drives Bone Formation in Classical MAP2K1+ Melorheostosis
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - September 23, 2023 Category: Orthopaedics Authors: Jules Allbritton ‐King, Jyotirindra Maity, Amit Patel, Robert A Colbert, Fatemeh Navid, Timothy Bhattacharyya Tags: Research Article Source Type: research

Issue Information ‐ Declaration of Helsinki
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - September 22, 2023 Category: Orthopaedics Tags: Issue Information ‐ Declaration of Helsinki Source Type: research

Ed Bd, Masthead, Comm List and TOC
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - September 22, 2023 Category: Orthopaedics Tags: Issue Information Source Type: research

Journal of Bone and Mineral Research: Volume 38, Number 9, September 2023
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - September 22, 2023 Category: Orthopaedics Tags: Cover Source Type: research

The Added Value of High ‐Resolution Peripheral Quantitative Computed Tomography in Fracture Risk Prediction
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - September 22, 2023 Category: Orthopaedics Authors: Mattias Lorentzon, Andrew J. Burghardt Tags: Editorial Source Type: research