Single ‐cell transcriptomics of bone marrow stromal cells in Diversity Outbred mice: a model for population‐level scRNA‐seq studies
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 12, 2023 Category: Orthopaedics Authors: Luke J Dillard, Will T Rosenow, Gina M Calabrese, Larry D Mesner, Basel M Al ‐Barghouthi, Abdullah Abood, Emily A Farber, Suna Onengut‐Gumuscu, Steven M Tommasini, Mark A Horowitz, Clifford J Rosen, Lutian Yao, Ling Qin, Charles R Farber Tags: Research Article Source Type: research

Evaluation of the effect of sodium ‐glucose cotransporter 2 inhibition on fracture risk: evidence from Mendelian randomization and genetic association study
This study aims to evaluate the causal effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on bone mineral density (BMD), osteoporosis, and fracture risk using genetics. Two-sample Mendelian randomization (MR) analyses were performed utilizing two sets of genetic variants as instruments (six and two single-nucleotide polymorphisms [SNPs]) associated withSLC5A2 gene expression and glycated hemoglobin A1c levels. Summary statistics of BMD from the Genetic Factors for Osteoporosis (GEFOS) consortium (BMD for total body, n  = 66,628; femoral neck, n = 32,735; lumbar spine, n = 28,498; forearm, n = 8,143...
Source: Journal of Bone and Mineral Research - July 12, 2023 Category: Orthopaedics Authors: Huajie Dai, Longyi Zheng, Zheng Zhu, Xin Geng, Tianzhichao Hou, Qi Wang, Yijie Zhu, Hong Lin, Shuangyuan Wang, Ruizhi Zheng, Zhiyun Zhao, Mian Li, Jieli Lu, Yu Xu, Tiange Wang, Jianmin Liu, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng Tags: Research Article Source Type: research

Efficacy and safety of transdermal abaloparatide in postmenopausal women with osteoporosis: a randomized study
The objective of this study was to evaluate efficacy and safety of abaloparatide microstructured transdermal system (abaloparatide-sMTS) as an alternative to the SC formulation.This phase 3, noninferiority study (NCT04064411) randomly assigned postmenopausal women with osteoporosis (N  = 511) 1:1 to open-label abaloparatide administered daily via abaloparatide-sMTS or SC injection for 12 months. Primary comparison between treatment groups was percentage change in lumbar spine bone mineral density (BMD) at 12 months, with a noninferiority margin of 2.0%. Secondary endpoint s included percentage change in total hip a...
Source: Journal of Bone and Mineral Research - July 8, 2023 Category: Orthopaedics Authors: E. Michael Lewiecki, Edward Czerwinski, Chris Recknor, Anna Strzelecka, Guillermo Valenzuela, Mary Lawrence, Stuart Silverman, Jose Cardona, Susan M. Nattrass, Neil Binkley, Miriam Annett, Leny Pearman, Bruce Mitlak Tags: Research Article Source Type: research

3d finite element models reconstructed from 2d dxa images improve hip fracture prediction compared to areal bmd in mros sweden cohort
ABSTRACTBone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction tools. 3D finite element (FE) models predict bone strength better than aBMD, but their clinical use is limited by the need for 3D computed tomography and lack of automation. We have earlier developed a method to reconstruct the 3D hip anatomy from a 2D DXA image, followed by subject-specific FE-based prediction of proximal femoral strength. In the current study, we aim to evaluate the method's ability to...
Source: Journal of Bone and Mineral Research - July 7, 2023 Category: Orthopaedics Authors: Lorenzo Grassi, Sami P. V äänänen, Lars Jehpsson, Östen Ljunggren, Björn E. Rosengren, Magnus K. Karlsson, Hanna Isaksson Tags: Research Article Source Type: research

Measurements of the Vitamin D Metabolome in the Calgary Vitamin D Study: Relationship of Vitamin D Metabolites to Bone Loss
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 7, 2023 Category: Orthopaedics Authors: Lauren A Burt, Martin Kaufmann, Marianne S Rose, Glenville Jones, Emma O Billington, Steven K Boyd, David A Hanley Tags: Clinical Trial Source Type: research

3d finite element models reconstructed from 2d dxa images improve hip fracture prediction compared to areal bmd in mros sweden cohort
ABSTRACTBone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction tools. 3D finite element (FE) models predict bone strength better than aBMD, but their clinical use is limited by the need for 3D computed tomography and lack of automation. We have earlier developed a method to reconstruct the 3D hip anatomy from a 2D DXA image, followed by subject-specific FE-based prediction of proximal femoral strength. In the current study, we aim to evaluate the method's ability to...
Source: Journal of Bone and Mineral Research - July 7, 2023 Category: Orthopaedics Authors: Lorenzo Grassi, Sami P. V äänänen, Lars Jehpsson, Östen Ljunggren, Björn E. Rosengren, Magnus K. Karlsson, Hanna Isaksson Tags: Research Article Source Type: research

Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society
ABSTRACTMajor achievements in bone research have always relied on animal models and in vitro systems derived from patient and animal material. However, the use of animals in research has drawn intense ethical debate and the complete abolition of animal experimentation is demanded by fractions of the population. This phenomenon is enhanced by the reproducibility crisis in science and the advance of in vitro and in silico techniques. 3D culture, organ-on-a-chip, and computer models have improved enormously over the last few years. Nevertheless, the overall complexity of bone tissue cross-talk and the systemic and local regul...
Source: Journal of Bone and Mineral Research - July 4, 2023 Category: Orthopaedics Authors: Merle Stein, Florent Elefteriou, Bj örn Busse, Imke AK Fiedler, Ronald Young Kwon, Eric Farrell, Mubashir Ahmad, Anita Ignatius, Liam Grover, Liesbet Geris, Jan Tuckermann Tags: Review Source Type: research

The Multifarious Functions of Leukotrienes in Bone Metabolism
Bone profile of 5-LO –deficient mouse model. We investigated the effects of leukotrienes on bone metabolism using a 5-LO KO mouse model. Long bones phenotype of females and males lacking 5-LO present thicker cortical bone and increased marrow area but decreased trabecular bone only in females. Osteoblasts from 5-LO KO mice show overexpression of bone formation markers leading to a decreased proliferation and increased osteoblast differentiation and mineralization. The osteoclastogenic profile of 5-LO KO mice presents impaired osteoclasts with the downregulation of bone resorption markers and cytokines, leading t o a dysf...
Source: Journal of Bone and Mineral Research - June 29, 2023 Category: Orthopaedics Authors: Fl ávia Amadeu de Oliveira, Cintia K. Tokuhara, Vimal Veeriah, João Paulo Domezi, Mariana R. Santesso, Tania M. Cestari, Talita M.O. Ventura, Adriana A. Matos, Thiago Dionísio, Marcel R. Ferreira, Rafael C. Ortiz, Marco A.H. Duarte, Maríli Tags: Research Article Source Type: research

Cortical and trabecular bone deficit in middle ‐aged men living with HIV
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 27, 2023 Category: Orthopaedics Authors: Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee Tags: Research Article Source Type: research

Interactions between HR ‐pQCT bone density and D3Cr muscle mass (or HR‐pQCT bone structure and HR‐pQCT muscle density) in predicting fractures: The Osteoporotic Fractures in Men study
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 24, 2023 Category: Orthopaedics Authors: Ben Kirk, Stephanie L Harrison, Jesse Zanker, Andrew J. Burghardt, Eric Orwoll, Gustavo Duque, Peggy M Cawthon Tags: Research Article Source Type: research

RNA Sequencing of Urine ‐Derived Cells for the Characterization and Diagnosis of Osteogenesis Imperfecta
In conclusion, UDC are suitable for RNA transcript analysis in patients with suspected OI and can provide functional evidence for pathogenicity, in particular of variants affecting splicing. © 2023 The Authors.Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 23, 2023 Category: Orthopaedics Authors: Karissa Ludwig, Zenghui Wu, Ghalib Bardai, Patrizia Mason, Leanne M Ward, Pierre Moffatt, Frank Rauch Tags: Research Article Source Type: research

Interactions between HR ‐pQCT bone density and D3Cr muscle mass (or HR‐pQCT bone structure and HR‐pQCT muscle density) in predicting fractures: The Osteoporotic Fractures in Men study
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 23, 2023 Category: Orthopaedics Authors: Ben Kirk, Stephanie L Harrison, Jesse Zanker, Andrew J. Burghardt, Eric Orwoll, Gustavo Duque, Peggy M Cawthon Tags: Research Article Source Type: research