Rapid cortical bone loss at the distal radius is associated with higher risk of fracture in older men – the STRAMBO study
AbstractRapid loss of areal bone mineral density (aBMD) is associated with higher fracture risk after adjustment for confounders including initial aBMD. However, the link between bone microarchitecture decline and fracture is not clear. We studied the association between bone microarchitecture deterioration assessed prospectively over 4  years and the subsequent fracture risk in older men. Bone microarchitecture at the distal radius and tibia was assessed by high resolution peripheral QCT (HR-pQCT; XtremeCT, Scanco Medical) (baseline, 4 years) in 732 men aged 60-87 years. During the 8-year follow-up, 109 men had frag...
Source: Journal of Bone and Mineral Research - March 29, 2023 Category: Orthopaedics Authors: Elina Gunsing, Philippe P. Wagner, Danielle E. Whittier, Steven K. Boyd, Roland Chapurlat, Pawel Szulc Tags: Research Article Source Type: research

Effect of a three ‐day course of dexamethasone on acute phase response following treatment with zoledronate: a randomized controlled trial
This study demonstrates that a three-day course of dexamethasone substantially reduces the acute phase response following zoledronate infusion.This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - March 27, 2023 Category: Orthopaedics Authors: Rachel Murdoch, Anna Mellar, Anne M Horne, Emma Billington, Pui Ling Chan, Gregory Gamble, Ian R Reid Tags: Clinical Trial Source Type: research