C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Jan;29(1-2):14-24. doi: 10.1177/17534259231162192. Epub 2023 Apr 24.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (cPRRs), that ...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Apr 24:17534259231162192. doi: 10.1177/17534259231162192. Online ahead of print.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (c...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Apr 24:17534259231162192. doi: 10.1177/17534259231162192. Online ahead of print.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (c...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Apr 24:17534259231162192. doi: 10.1177/17534259231162192. Online ahead of print.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (c...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Apr 24:17534259231162192. doi: 10.1177/17534259231162192. Online ahead of print.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (c...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
