Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
Increased circulating monocyte MDSCs positively correlate with serum Interleukin-10 in metastatic melanoma patients
In this study MM patients have significantly higher percentage of CD14 + HLA-DR- mMDSCs, as well as increased the baseline mMDSC/PBMC subset (NK, T, B cells, monocytes) ratio. Although there is no significant difference in the percentage of mMDSCs between groups of MM patients with different localization of distant metastasis, patients with elevated serum lactate dehydrogenase (LDH) have statistically significant higher percentage of these cells compared to LDH negative patients. Furthermore, in MM patients there is statistically significant positive correlation between values of IL-10 and the percentage of mMDSCs, only. T...
Source: Innate Immunity - May 10, 2023 Category: Allergy & Immunology Authors: Katarina Mirja čić Martinović Ana Vuleti ć Nevena Ti šma Miletić Milica Nedeljkovi ć Nada Babovi ć Suzana Matkovi ć Vladimir Juri šić Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Jan;29(1-2):14-24. doi: 10.1177/17534259231162192. Epub 2023 Apr 24.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (cPRRs), that ...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Jan;29(1-2):14-24. doi: 10.1177/17534259231162192. Epub 2023 Apr 24.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (cPRRs), that ...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Jan;29(1-2):14-24. doi: 10.1177/17534259231162192. Epub 2023 Apr 24.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (cPRRs), that ...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
C/EBP β deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
Innate Immun. 2023 Jan;29(1-2):14-24. doi: 10.1177/17534259231162192. Epub 2023 Apr 24.ABSTRACTThe skin is the first line of defense to cutaneous microbes and viruses, and epidermal keratinocytes play a critical role in preventing infection by viruses and pathogens through activation of the type I interferon (IFN) response. Using RNAseq analysis, here we report that the conditional deletion of C/EBPβ transcription factor in mouse epidermis (CKOβ mice) resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs). The expression of cytosolic pattern recognition receptors (cPRRs), that ...
Source: Innate Immunity - April 24, 2023 Category: Allergy & Immunology Authors: John S House Sophia Gray Jennifer R Owen Dereje D Jima Robert C Smart Jonathan R Hall Source Type: research
