Obesity Alters cytokine signaling and gut microbiome in septic mice
Innate Immun. 2023 Oct 6:17534259231205959. doi: 10.1177/17534259231205959. Online ahead of print.ABSTRACTSepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old C57BL/6 male mice were randomized to control (non-obese) or high fat diet (obese) for 5-7 weeks. Sepsis was induced by cecal ligation and perforation (CLP). Cytokine levels were measured from cheek bleeds 8 h after CLP, and mice were monitored for survival. Other cohor...
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Lauren Bodilly Lauren Williamson Patrick Lahni Matthew N Alder David B Haslam Jennifer M Kaplan Source Type: research
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation
In conclusion, newly developed FP1 improves the graft survival in cardiac transplantation mouse model. Significant additional work to optimize FP1 or include other novel proteins could supplement current treatment options for transplant patients.PMID:37800911 | DOI:10.1177/17534259231186239 (Source: Innate Immunity)
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Young S Lee I-Ting Cheng Godoy-Ruiz Raquel David J Weber Joseph R Scalea Source Type: research
Obesity Alters cytokine signaling and gut microbiome in septic mice
Innate Immun. 2023 Oct 6:17534259231205959. doi: 10.1177/17534259231205959. Online ahead of print.ABSTRACTSepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old C57BL/6 male mice were randomized to control (non-obese) or high fat diet (obese) for 5-7 weeks. Sepsis was induced by cecal ligation and perforation (CLP). Cytokine levels were measured from cheek bleeds 8 h after CLP, and mice were monitored for survival. Other cohor...
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Lauren Bodilly Lauren Williamson Patrick Lahni Matthew N Alder David B Haslam Jennifer M Kaplan Source Type: research
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation
In conclusion, newly developed FP1 improves the graft survival in cardiac transplantation mouse model. Significant additional work to optimize FP1 or include other novel proteins could supplement current treatment options for transplant patients.PMID:37800911 | DOI:10.1177/17534259231186239 (Source: Innate Immunity)
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Young S Lee I-Ting Cheng Godoy-Ruiz Raquel David J Weber Joseph R Scalea Source Type: research
Obesity Alters cytokine signaling and gut microbiome in septic mice
Innate Immun. 2023 Oct 6:17534259231205959. doi: 10.1177/17534259231205959. Online ahead of print.ABSTRACTSepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old C57BL/6 male mice were randomized to control (non-obese) or high fat diet (obese) for 5-7 weeks. Sepsis was induced by cecal ligation and perforation (CLP). Cytokine levels were measured from cheek bleeds 8 h after CLP, and mice were monitored for survival. Other cohor...
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Lauren Bodilly Lauren Williamson Patrick Lahni Matthew N Alder David B Haslam Jennifer M Kaplan Source Type: research
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation
In conclusion, newly developed FP1 improves the graft survival in cardiac transplantation mouse model. Significant additional work to optimize FP1 or include other novel proteins could supplement current treatment options for transplant patients.PMID:37800911 | DOI:10.1177/17534259231186239 (Source: Innate Immunity)
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Young S Lee I-Ting Cheng Godoy-Ruiz Raquel David J Weber Joseph R Scalea Source Type: research
Obesity Alters cytokine signaling and gut microbiome in septic mice
Innate Immun. 2023 Oct 6:17534259231205959. doi: 10.1177/17534259231205959. Online ahead of print.ABSTRACTSepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old C57BL/6 male mice were randomized to control (non-obese) or high fat diet (obese) for 5-7 weeks. Sepsis was induced by cecal ligation and perforation (CLP). Cytokine levels were measured from cheek bleeds 8 h after CLP, and mice were monitored for survival. Other cohor...
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Lauren Bodilly Lauren Williamson Patrick Lahni Matthew N Alder David B Haslam Jennifer M Kaplan Source Type: research
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation
In conclusion, newly developed FP1 improves the graft survival in cardiac transplantation mouse model. Significant additional work to optimize FP1 or include other novel proteins could supplement current treatment options for transplant patients.PMID:37800911 | DOI:10.1177/17534259231186239 (Source: Innate Immunity)
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Young S Lee I-Ting Cheng Godoy-Ruiz Raquel David J Weber Joseph R Scalea Source Type: research
Obesity Alters cytokine signaling and gut microbiome in septic mice
Innate Immun. 2023 Oct 6:17534259231205959. doi: 10.1177/17534259231205959. Online ahead of print.ABSTRACTSepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old C57BL/6 male mice were randomized to control (non-obese) or high fat diet (obese) for 5-7 weeks. Sepsis was induced by cecal ligation and perforation (CLP). Cytokine levels were measured from cheek bleeds 8 h after CLP, and mice were monitored for survival. Other cohor...
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Lauren Bodilly Lauren Williamson Patrick Lahni Matthew N Alder David B Haslam Jennifer M Kaplan Source Type: research
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation
In conclusion, newly developed FP1 improves the graft survival in cardiac transplantation mouse model. Significant additional work to optimize FP1 or include other novel proteins could supplement current treatment options for transplant patients.PMID:37800911 | DOI:10.1177/17534259231186239 (Source: Innate Immunity)
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Young S Lee I-Ting Cheng Godoy-Ruiz Raquel David J Weber Joseph R Scalea Source Type: research
Obesity Alters cytokine signaling and gut microbiome in septic mice
Innate Immun. 2023 Oct 6:17534259231205959. doi: 10.1177/17534259231205959. Online ahead of print.ABSTRACTSepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week-old C57BL/6 male mice were randomized to control (non-obese) or high fat diet (obese) for 5-7 weeks. Sepsis was induced by cecal ligation and perforation (CLP). Cytokine levels were measured from cheek bleeds 8 h after CLP, and mice were monitored for survival. Other cohor...
Source: Innate Immunity - October 6, 2023 Category: Allergy & Immunology Authors: Lauren Bodilly Lauren Williamson Patrick Lahni Matthew N Alder David B Haslam Jennifer M Kaplan Source Type: research
Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands
Innate Immun. 2023 Oct;29(7):135-149. doi: 10.1177/17534259231191252. Epub 2023 Aug 22.ABSTRACTIn the mammary glands, production of antimicrobial components and formation of less-permeable tight junctions (TJs) are important for safe milk production. Previously, we reported that local heat treatment of udders using disposable heating pad enhances the components of innate immunity in lactating goat mammary glands. Gingerol is a polyphenol present in ginger that can induce heat-like effects. However, oral administration of polyphenols causes a decrease in biological activity through conjugation and metabolic conversion. Here...
Source: Innate Immunity - August 22, 2023 Category: Allergy & Immunology Authors: Yusaku Tsugami Takahiro Nii Ken Kobayashi Naoki Isobe Source Type: research
Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands
Innate Immun. 2023 Aug 22:17534259231191252. doi: 10.1177/17534259231191252. Online ahead of print.ABSTRACTIn the mammary glands, production of antimicrobial components and formation of less-permeable tight junctions (TJs) are important for safe milk production. Previously, we reported that local heat treatment of udders using disposable heating pad enhances the components of innate immunity in lactating goat mammary glands. Gingerol is a polyphenol present in ginger that can induce heat-like effects. However, oral administration of polyphenols causes a decrease in biological activity through conjugation and metabolic conv...
Source: Innate Immunity - August 22, 2023 Category: Allergy & Immunology Authors: Yusaku Tsugami Takahiro Nii Ken Kobayashi Naoki Isobe Source Type: research
Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands
Innate Immun. 2023 Aug 22:17534259231191252. doi: 10.1177/17534259231191252. Online ahead of print.ABSTRACTIn the mammary glands, production of antimicrobial components and formation of less-permeable tight junctions (TJs) are important for safe milk production. Previously, we reported that local heat treatment of udders using disposable heating pad enhances the components of innate immunity in lactating goat mammary glands. Gingerol is a polyphenol present in ginger that can induce heat-like effects. However, oral administration of polyphenols causes a decrease in biological activity through conjugation and metabolic conv...
Source: Innate Immunity - August 22, 2023 Category: Allergy & Immunology Authors: Yusaku Tsugami Takahiro Nii Ken Kobayashi Naoki Isobe Source Type: research
Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands
Innate Immun. 2023 Aug 22:17534259231191252. doi: 10.1177/17534259231191252. Online ahead of print.ABSTRACTIn the mammary glands, production of antimicrobial components and formation of less-permeable tight junctions (TJs) are important for safe milk production. Previously, we reported that local heat treatment of udders using disposable heating pad enhances the components of innate immunity in lactating goat mammary glands. Gingerol is a polyphenol present in ginger that can induce heat-like effects. However, oral administration of polyphenols causes a decrease in biological activity through conjugation and metabolic conv...
Source: Innate Immunity - August 22, 2023 Category: Allergy & Immunology Authors: Yusaku Tsugami Takahiro Nii Ken Kobayashi Naoki Isobe Source Type: research
