Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists
In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacter...
Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research
Role of neutrophils in different stages of atherosclerosis
Innate Immun. 2023 Jul 25:17534259231189195. doi: 10.1177/17534259231189195. Online ahead of print.ABSTRACTNeutrophils constitute the first line of defense in human immunity and can be attracted to inflamed and infected sites by various chemokines. As essential players in immune processes, neutrophils theoretically play integral roles in the course of chronic inflammation-induced atherosclerosis. However, because neutrophils are rarely found in atherosclerotic lesions, their involvement in the pathophysiological progression of atherosclerosis has been largely underestimated or ignored. Recent research has revealed convinci...
Source: Innate Immunity - July 26, 2023 Category: Allergy & Immunology Authors: Xiaojing Zhang Zhanfang Kang Dazhong Yin Jun Gao Source Type: research
Role of neutrophils in different stages of atherosclerosis
Innate Immun. 2023 Jul 25:17534259231189195. doi: 10.1177/17534259231189195. Online ahead of print.ABSTRACTNeutrophils constitute the first line of defense in human immunity and can be attracted to inflamed and infected sites by various chemokines. As essential players in immune processes, neutrophils theoretically play integral roles in the course of chronic inflammation-induced atherosclerosis. However, because neutrophils are rarely found in atherosclerotic lesions, their involvement in the pathophysiological progression of atherosclerosis has been largely underestimated or ignored. Recent research has revealed convinci...
Source: Innate Immunity - July 26, 2023 Category: Allergy & Immunology Authors: Xiaojing Zhang Zhanfang Kang Dazhong Yin Jun Gao Source Type: research
Role of neutrophils in different stages of atherosclerosis
Innate Immun. 2023 Jul 25:17534259231189195. doi: 10.1177/17534259231189195. Online ahead of print.ABSTRACTNeutrophils constitute the first line of defense in human immunity and can be attracted to inflamed and infected sites by various chemokines. As essential players in immune processes, neutrophils theoretically play integral roles in the course of chronic inflammation-induced atherosclerosis. However, because neutrophils are rarely found in atherosclerotic lesions, their involvement in the pathophysiological progression of atherosclerosis has been largely underestimated or ignored. Recent research has revealed convinci...
Source: Innate Immunity - July 26, 2023 Category: Allergy & Immunology Authors: Xiaojing Zhang Zhanfang Kang Dazhong Yin Jun Gao Source Type: research
Role of neutrophils in different stages of atherosclerosis
Innate Immun. 2023 Jul 25:17534259231189195. doi: 10.1177/17534259231189195. Online ahead of print.ABSTRACTNeutrophils constitute the first line of defense in human immunity and can be attracted to inflamed and infected sites by various chemokines. As essential players in immune processes, neutrophils theoretically play integral roles in the course of chronic inflammation-induced atherosclerosis. However, because neutrophils are rarely found in atherosclerotic lesions, their involvement in the pathophysiological progression of atherosclerosis has been largely underestimated or ignored. Recent research has revealed convinci...
Source: Innate Immunity - July 26, 2023 Category: Allergy & Immunology Authors: Xiaojing Zhang Zhanfang Kang Dazhong Yin Jun Gao Source Type: research
Role of neutrophils in different stages of atherosclerosis
Innate Immun. 2023 Jul 25:17534259231189195. doi: 10.1177/17534259231189195. Online ahead of print.ABSTRACTNeutrophils constitute the first line of defense in human immunity and can be attracted to inflamed and infected sites by various chemokines. As essential players in immune processes, neutrophils theoretically play integral roles in the course of chronic inflammation-induced atherosclerosis. However, because neutrophils are rarely found in atherosclerotic lesions, their involvement in the pathophysiological progression of atherosclerosis has been largely underestimated or ignored. Recent research has revealed convinci...
Source: Innate Immunity - July 26, 2023 Category: Allergy & Immunology Authors: Xiaojing Zhang Zhanfang Kang Dazhong Yin Jun Gao Source Type: research
