Intensive Care Treatment of Pulmonary Embolism: An Update Based on the Revised AWMF S2k Guideline
Hamostaseologie. 2024 Mar 18. doi: 10.1055/a-2237-7428. Online ahead of print.ABSTRACTAcute pulmonary embolism (PE) remains a significant cause of morbidity and requires prompt diagnosis and management. The prognosis of affected patients depends on the clinical severity. Therefore, risk stratification is imperative for therapeutic decision-making. Patients with high-risk PE need intensive care. These include patients who have successfully survived resuscitation, with obstructive shock or persistent haemodynamic instability. Bedside diagnostics by means of sonographic procedures are of outstanding importance in this high-ri...
Source: Hamostaseologie - March 18, 2024 Category: Hematology Authors: Uwe Janssens Source Type: research
Novel Perspectives on Thrombopoietin Receptor Agonists Applications
Hamostaseologie. 2024 Mar 18. doi: 10.1055/a-2250-9369. Online ahead of print.ABSTRACTSecond-generation thrombopoietin receptor agonists (TPO-RAs), romiplostim, eltrombopag, and avatrombopag, have been proved to be significant stimulators of megakaryopoiesis and, in the last decade, they have been incorporated in the treatment options against refractory immune thrombocytopenia in children and adults that do not respond to conventional therapy. Additionally, given their beneficial impact on hematopoiesis, they have successfully been applied in cases of non-immune thrombocytopenia, such as aplastic anemia, HCV-related thromb...
Source: Hamostaseologie - March 18, 2024 Category: Hematology Authors: Christos Stafylidis Dimitra Vlachopoulou Stavroula Syriopoulou Sevastianos Chatzidavid Nora-Athina Viniou Source Type: research
The Current Evidence of Pulmonary Embolism Response Teams and Their Role in Future
Hamostaseologie. 2024 Mar 12. doi: 10.1055/a-2232-5395. Online ahead of print.ABSTRACTAcute pulmonary embolism (PE) remains a critical medical condition requiring prompt and accurate management. The introduction and growing significance of pulmonary embolism response teams (PERT), also termed EXPERT-PE teams, signify a paradigm shift toward a collaborative, multidisciplinary approach in managing this complex entity. As the understanding of acute PE continues to evolve, PERTs stand as a linkage of optimized care, offering personalized and evidence-based management strategies for patients afflicted by this life-threatening c...
Source: Hamostaseologie - March 12, 2024 Category: Hematology Authors: Lukas Hobohm Ioannis T Farmakis Daniel Duerschmied Karsten Keller Source Type: research
The Current Evidence of Pulmonary Embolism Response Teams and Their Role in Future
Hamostaseologie. 2024 Mar 12. doi: 10.1055/a-2232-5395. Online ahead of print.ABSTRACTAcute pulmonary embolism (PE) remains a critical medical condition requiring prompt and accurate management. The introduction and growing significance of pulmonary embolism response teams (PERT), also termed EXPERT-PE teams, signify a paradigm shift toward a collaborative, multidisciplinary approach in managing this complex entity. As the understanding of acute PE continues to evolve, PERTs stand as a linkage of optimized care, offering personalized and evidence-based management strategies for patients afflicted by this life-threatening c...
Source: Hamostaseologie - March 12, 2024 Category: Hematology Authors: Lukas Hobohm Ioannis T Farmakis Daniel Duerschmied Karsten Keller Source Type: research
The Current Evidence of Pulmonary Embolism Response Teams and Their Role in Future
Hamostaseologie. 2024 Mar 12. doi: 10.1055/a-2232-5395. Online ahead of print.ABSTRACTAcute pulmonary embolism (PE) remains a critical medical condition requiring prompt and accurate management. The introduction and growing significance of pulmonary embolism response teams (PERT), also termed EXPERT-PE teams, signify a paradigm shift toward a collaborative, multidisciplinary approach in managing this complex entity. As the understanding of acute PE continues to evolve, PERTs stand as a linkage of optimized care, offering personalized and evidence-based management strategies for patients afflicted by this life-threatening c...
Source: Hamostaseologie - March 12, 2024 Category: Hematology Authors: Lukas Hobohm Ioannis T Farmakis Daniel Duerschmied Karsten Keller Source Type: research
The Current Evidence of Pulmonary Embolism Response Teams and Their Role in Future
Hamostaseologie. 2024 Mar 12. doi: 10.1055/a-2232-5395. Online ahead of print.ABSTRACTAcute pulmonary embolism (PE) remains a critical medical condition requiring prompt and accurate management. The introduction and growing significance of pulmonary embolism response teams (PERT), also termed EXPERT-PE teams, signify a paradigm shift toward a collaborative, multidisciplinary approach in managing this complex entity. As the understanding of acute PE continues to evolve, PERTs stand as a linkage of optimized care, offering personalized and evidence-based management strategies for patients afflicted by this life-threatening c...
Source: Hamostaseologie - March 12, 2024 Category: Hematology Authors: Lukas Hobohm Ioannis T Farmakis Daniel Duerschmied Karsten Keller Source Type: research
The Current Evidence of Pulmonary Embolism Response Teams and Their Role in Future
Hamostaseologie. 2024 Mar 12. doi: 10.1055/a-2232-5395. Online ahead of print.ABSTRACTAcute pulmonary embolism (PE) remains a critical medical condition requiring prompt and accurate management. The introduction and growing significance of pulmonary embolism response teams (PERT), also termed EXPERT-PE teams, signify a paradigm shift toward a collaborative, multidisciplinary approach in managing this complex entity. As the understanding of acute PE continues to evolve, PERTs stand as a linkage of optimized care, offering personalized and evidence-based management strategies for patients afflicted by this life-threatening c...
Source: Hamostaseologie - March 12, 2024 Category: Hematology Authors: Lukas Hobohm Ioannis T Farmakis Daniel Duerschmied Karsten Keller Source Type: research
Quantifying Residual Rivaroxaban Plasma Concentration after Antagonization with Andexanet Alfa: A Difficult Task in Routine Clinical Practice
We describe the case of a 38-year-old man with a history of chronic portal vein thrombosis who presented with abdominal pain after a transjugular intrahepatic portosystemic shunt procedure. Under anticoagulation therapy with rivaroxaban, he experienced active splenic bleeding, leading to hemodynamic instability. Emergency interventions, including andexanet alfa and nanoparticle administration, successfully stopped the bleeding. However, routine tests showed persistently high rivaroxaban levels despite reversal with andexanet alfa. This case report shows that next to standard anti-Xa activity assay, high-performance liquid ...
Source: Hamostaseologie - March 11, 2024 Category: Hematology Authors: Alexander Mair Gilles Huber Jan-Dirk Studt Donat R Spahn Alexander Kaserer Source Type: research
Direct Oral Anticoagulants for Pulmonary Embolism
Hamostaseologie. 2024 Mar 11. doi: 10.1055/a-2105-8736. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is the third most common cardiovascular disease. For most patients, the standard of treatment has long consisted on low-molecular-weight heparin followed by vitamin K antagonists, but a number of clinical trials and, subsequently, post-marketing studies have shown that direct oral anticoagulants (DOACs) with or without lead-in heparin therapy are effective alternatives with fewer adverse effects. This evidence has led to important changes in the guidelines on the treatment of VTE, including pulmonary embolism ...
Source: Hamostaseologie - March 11, 2024 Category: Hematology Authors: Roberto Pizzi Ludovica Anna Cimini Walter Ageno Cecilia Becattini Source Type: research
Thrombosis in Acute Promyelocytic Leukemia: The Current Understanding
Hamostaseologie. 2024 Mar 11. doi: 10.1055/a-2238-4782. Online ahead of print.ABSTRACTDespite enormous improvement in the management of patients with acute promyelocytic leukemia (APL), the distinctive coagulopathy observed at presentation in affected patients is often life-threatening. While hemorrhagic manifestations are well known and described in this setting, APL-related thromboses are underappreciated. Data regarding this complication are scarce showing variable incidence. Furthermore, risk factors for thrombosis are inconsistent and unreliable; so, differentiation of increased risk of hemorrhage from an increased th...
Source: Hamostaseologie - March 11, 2024 Category: Hematology Authors: Nikica Sabljic Mirjana Mitrovic Nikola Pantic Jecko Thachil Source Type: research
Quantifying Residual Rivaroxaban Plasma Concentration after Antagonization with Andexanet Alfa: A Difficult Task in Routine Clinical Practice
We describe the case of a 38-year-old man with a history of chronic portal vein thrombosis who presented with abdominal pain after a transjugular intrahepatic portosystemic shunt procedure. Under anticoagulation therapy with rivaroxaban, he experienced active splenic bleeding, leading to hemodynamic instability. Emergency interventions, including andexanet alfa and nanoparticle administration, successfully stopped the bleeding. However, routine tests showed persistently high rivaroxaban levels despite reversal with andexanet alfa. This case report shows that next to standard anti-Xa activity assay, high-performance liquid ...
Source: Hamostaseologie - March 11, 2024 Category: Hematology Authors: Alexander Mair Gilles Huber Jan-Dirk Studt Donat R Spahn Alexander Kaserer Source Type: research
Direct Oral Anticoagulants for Pulmonary Embolism
Hamostaseologie. 2024 Mar 11. doi: 10.1055/a-2105-8736. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is the third most common cardiovascular disease. For most patients, the standard of treatment has long consisted on low-molecular-weight heparin followed by vitamin K antagonists, but a number of clinical trials and, subsequently, post-marketing studies have shown that direct oral anticoagulants (DOACs) with or without lead-in heparin therapy are effective alternatives with fewer adverse effects. This evidence has led to important changes in the guidelines on the treatment of VTE, including pulmonary embolism ...
Source: Hamostaseologie - March 11, 2024 Category: Hematology Authors: Roberto Pizzi Ludovica Anna Cimini Walter Ageno Cecilia Becattini Source Type: research
Thrombosis in Acute Promyelocytic Leukemia: The Current Understanding
Hamostaseologie. 2024 Mar 11. doi: 10.1055/a-2238-4782. Online ahead of print.ABSTRACTDespite enormous improvement in the management of patients with acute promyelocytic leukemia (APL), the distinctive coagulopathy observed at presentation in affected patients is often life-threatening. While hemorrhagic manifestations are well known and described in this setting, APL-related thromboses are underappreciated. Data regarding this complication are scarce showing variable incidence. Furthermore, risk factors for thrombosis are inconsistent and unreliable; so, differentiation of increased risk of hemorrhage from an increased th...
Source: Hamostaseologie - March 11, 2024 Category: Hematology Authors: Nikica Sabljic Mirjana Mitrovic Nikola Pantic Jecko Thachil Source Type: research
Understanding complex processes better-A case study on increasing patient safety and efficiency in a central operating room
CONCLUSION: The FRAM conducted provides valuable new insights into the functioning of complex sociotechnical systems that go far beyond classical linear methods. The awareness of operational processes gained and the resulting dynamic view of interactions within the system enable specific measures to be derived that promote resilient behavior and reduce critical variability, thus contributing to increased patient safety and efficiency.PMID:38459378 | DOI:10.1007/s00101-024-01390-9 (Source: Hamostaseologie)
Source: Hamostaseologie - March 8, 2024 Category: Hematology Authors: Tillmann Speer Thomas M ühlbradt Helga Unger Christian Fastner Stefan Schr öder Source Type: research
Understanding complex processes better-A case study on increasing patient safety and efficiency in a central operating room
CONCLUSION: The FRAM conducted provides valuable new insights into the functioning of complex sociotechnical systems that go far beyond classical linear methods. The awareness of operational processes gained and the resulting dynamic view of interactions within the system enable specific measures to be derived that promote resilient behavior and reduce critical variability, thus contributing to increased patient safety and efficiency.PMID:38459378 | DOI:10.1007/s00101-024-01390-9 (Source: Hamostaseologie)
Source: Hamostaseologie - March 8, 2024 Category: Hematology Authors: Tillmann Speer Thomas M ühlbradt Helga Unger Christian Fastner Stefan Schr öder Source Type: research
