Luspatercept: A peaceful revolution in the standard of care for myelodysplastic neoplasms
Hemasphere. 2024 Mar 3;8(3):e41. doi: 10.1002/hem3.41. eCollection 2024 Mar.NO ABSTRACTPMID:38434962 | PMC:PMC10909388 | DOI:10.1002/hem3.41 (Source: Hamostaseologie)
Source: Hamostaseologie - March 4, 2024 Category: Hematology Authors: Francesca Vinchi Uwe Platzbecker Source Type: research
Luspatercept: A peaceful revolution in the standard of care for myelodysplastic neoplasms
Hemasphere. 2024 Mar 3;8(3):e41. doi: 10.1002/hem3.41. eCollection 2024 Mar.NO ABSTRACTPMID:38434962 | PMC:PMC10909388 | DOI:10.1002/hem3.41 (Source: Hamostaseologie)
Source: Hamostaseologie - March 4, 2024 Category: Hematology Authors: Francesca Vinchi Uwe Platzbecker Source Type: research
Anti-Thrombin IgA in a Patient with Multiple Myeloma Leading to In Vitro Interference in Multiple Coagulation Tests and Confounding Diagnosis
CONCLUSION: Antibodies to human thrombin may interfere with all coagulation assays involving thrombin, imitating a severe coagulopathy. However, in vivo they do not necessarily lead to strongly increased bleeding tendency. Complex and ambiguous coagulation abnormalities should be evaluated and treated in an interdisciplinary setting, including a highly specialized coagulation laboratory, from the beginning.PMID:38428837 | DOI:10.1055/a-2211-6841 (Source: Hamostaseologie)
Source: Hamostaseologie - March 1, 2024 Category: Hematology Authors: Christian Irsara Andrea Griesmacher Lorin Loacker Clemens Feistritzer Cosima Anna Überbacher Jean Amiral Source Type: research
Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period
Hamostaseologie. 2024 Mar 1. doi: 10.1055/a-2238-4744. Online ahead of print.ABSTRACTChanges in the hemostatic system during COVID infection lead to hypercoagulability. Numerous studies have evaluated hemostatic abnormalities in COVID patients during acute infection, in the period of hospitalization. However, the hemostatic status following hospital discharge has not been sufficiently assessed. Considering the importance of FVIII and D-dimer levels as markers for the assessment of thrombosis, our study aimed to evaluate changes in these markers, as well as the influence of patient's age and clinical presentation of COVID i...
Source: Hamostaseologie - March 1, 2024 Category: Hematology Authors: Mirjana Kovac Milena Todorovic Balint Marija Milenkovic Dusica Basaric Branko Tomic Bela Balint Vera Ignjatovic Source Type: research
Anti-Thrombin IgA in a Patient with Multiple Myeloma Leading to In Vitro Interference in Multiple Coagulation Tests and Confounding Diagnosis
CONCLUSION: Antibodies to human thrombin may interfere with all coagulation assays involving thrombin, imitating a severe coagulopathy. However, in vivo they do not necessarily lead to strongly increased bleeding tendency. Complex and ambiguous coagulation abnormalities should be evaluated and treated in an interdisciplinary setting, including a highly specialized coagulation laboratory, from the beginning.PMID:38428837 | DOI:10.1055/a-2211-6841 (Source: Hamostaseologie)
Source: Hamostaseologie - March 1, 2024 Category: Hematology Authors: Christian Irsara Andrea Griesmacher Lorin Loacker Clemens Feistritzer Cosima Anna Überbacher Jean Amiral Source Type: research
Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period
Hamostaseologie. 2024 Mar 1. doi: 10.1055/a-2238-4744. Online ahead of print.ABSTRACTChanges in the hemostatic system during COVID infection lead to hypercoagulability. Numerous studies have evaluated hemostatic abnormalities in COVID patients during acute infection, in the period of hospitalization. However, the hemostatic status following hospital discharge has not been sufficiently assessed. Considering the importance of FVIII and D-dimer levels as markers for the assessment of thrombosis, our study aimed to evaluate changes in these markers, as well as the influence of patient's age and clinical presentation of COVID i...
Source: Hamostaseologie - March 1, 2024 Category: Hematology Authors: Mirjana Kovac Milena Todorovic Balint Marija Milenkovic Dusica Basaric Branko Tomic Bela Balint Vera Ignjatovic Source Type: research
GTH 2024: Building Bridges in Coagulation
Hamostaseologie. 2024 Feb;44(1):5-6. doi: 10.1055/s-0044-1779290. Epub 2024 Feb 28.NO ABSTRACTPMID:38417797 | DOI:10.1055/s-0044-1779290 (Source: Hamostaseologie)
Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: Cihan Ay Christoph Male Source Type: research
Vakzin-induzierte Immunthrombozytopenie und Thrombose: Langfristiger Outcome
Hamostaseologie. 2024 Feb;44(1):8. doi: 10.1055/s-0044-1782593. Epub 2024 Feb 28.ABSTRACTDIE RASCHE DIAGNOSE UND BEHANDLUNG HAT DEN OUTCOME VON PATIENTEN MIT VAKZIN-INDUZIERTER IMMUNTHROMBOZYTOPENIE UND -THROMBOSE (VITT) VERBESSERT. NACH DER AKUTEN EPISODE SIND JEDOCH VIELE FRAGEN HINSICHTLICH DES LANGFRISTIGEN MANAGEMENTS EINER VITT UNGEKLäRT. DIESEN WIDMETEN SICH NUN L. SCHöNBORN UND KOLLEGEN.PMID:38417798 | DOI:10.1055/s-0044-1782593 (Source: Hamostaseologie)
Source: Hamostaseologie - February 28, 2024 Category: Hematology Source Type: research
Thrombozytopenie: Sind Thrombozytentransfusionen vor Legen eines ZVK verzichtbar?
Hamostaseologie. 2024 Feb;44(1):10. doi: 10.1055/s-0044-1782594. Epub 2024 Feb 28.ABSTRACTDIE TRANSFUSIONSRICHTLINIEN BEZüGLICH DER SCHWELLENWERTE FüR DIE THROMBOZYTENZAHL VOR DEM LEGEN EINES ZENTRALEN VENENKATHETERS (ZVK) ENTHALTEN WIDERSPRüCHLICHE EMPFEHLUNGEN, DA QUALITATIV HOCHWERTIGE UND AUSSAGEKRäFTIGE BELEGE FEHLEN. DER ROUTINEMäßIGE EINSATZ VON ULTRASCHALL HAT DIE BLUTUNGSKOMPLIKATIONEN VERRINGERT. F. L. F. VAN BAARLE UND KOLLEGEN üBERPRüFTEN NUN, WIE DER VERZICHT AUF ENTSPRECHENDE TRANSFUSIONEN DAS BLUTUNGSRISIKO BEEINFLUSST.PMID:38417799 | DOI:10.1055/s-0044-1782594 (Source: Hamostaseologie)
Source: Hamostaseologie - February 28, 2024 Category: Hematology Source Type: research
PAS: Die Rolle von Natriumcitrat bei l ängerer Kaltlagerung von Thrombozyten
Hamostaseologie. 2024 Feb;44(1):12. doi: 10.1055/s-0044-1782595. Epub 2024 Feb 28.ABSTRACTKALT GELAGERTE BLUTPLäTTCHEN FINDEN IN DER BEHANDLUNG VON BLUTUNGEN ZUNEHMEND VERWENDUNG. UNTERSCHIEDE IN DEN HERSTELLUNGSVERFAHREN UND LAGERUNGSLöSUNGEN KöNNEN DIE QUALITäT DER THROMBOZYTEN UND IHRE HALTBARKEIT JEDOCH BEEINFLUSSEN. PAS-E UND PAS-F SIND IN EUROPA UND AUSTRALIEN BZW. IN DEN VEREINIGTEN STAATEN ZUGELASSENE ADDITIVLöSUNGEN (PAS). L. JOHNSON UND KOLLEGEN PRüFTEN NUN, OB LABOR- UND KLINISCHE DATEN INTERNATIONAL üBERTRAGBAR SIND.PMID:38417800 | DOI:10.1055/s-0044-1782595 (Source: Hamostaseologie)
Source: Hamostaseologie - February 28, 2024 Category: Hematology Source Type: research
Clonal Hematopoiesis and Cardiovascular Risk: Atherosclerosis, Thrombosis, and beyond
Hamostaseologie. 2024 Feb;44(1):13-20. doi: 10.1055/a-2219-6410. Epub 2024 Feb 28.ABSTRACTAcquired mutations that lead to clonal hematopoiesis have emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Human sequencing studies and experiments in mouse models provide compelling evidence supporting that this condition, particularly when driven by specific mutated genes, contributes to the development of atherosclerosis by exacerbating inflammatory responses. The insights gained from these studies are paving the way for the development of new personalized preve...
Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: Benedetta Izzi Jos é J Fuster Source Type: research
The Concept of Thromboinflammation
Hamostaseologie. 2024 Feb;44(1):21-30. doi: 10.1055/a-2178-6491. Epub 2024 Feb 28.ABSTRACTInflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead t...
Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: Waltraud C Schrottmaier Alice Assinger Source Type: research
Pathophysiology of Trauma-Induced Coagulopathy
Hamostaseologie. 2024 Feb;44(1):31-39. doi: 10.1055/a-2215-8936. Epub 2024 Feb 28.ABSTRACTTrauma-induced coagulopathy (TIC) is a complex hemostatic disturbance that can develop early after a major injury. There is no universally accepted definition of TIC. However, TIC primarily refers to the inability to achieve sufficient hemostasis in severely injured trauma patients, resulting in diffuse microvascular and life-threatening bleeding. Endogenous TIC is driven by the combination of hypovolemic shock and substantial tissue injury, resulting in endothelial damage, glycocalyx shedding, upregulated fibrinolysis, fibrinogen dep...
Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: Herbert Sch öchl Felix C F Schmitt Marc Maegele Source Type: research
100 Years of Thrombotic Thrombocytopenic Purpura: A Story of Death and Life
Hamostaseologie. 2024 Feb;44(1):59-73. doi: 10.1055/a-2223-9484. Epub 2024 Feb 28.ABSTRACTOne hundred years ago, in 1924, the first description of a patient with a disease, now known as thrombotic thrombocytopenic purpura (TTP) was published by Dr. Eli Moschcowitz. In honor of this report, this article, written by distinguished specialists in TTP, reviews the increase in scientific knowledge on this disease during the last 100 years. It covers the scientific progress from plasma therapy, the first beneficial treatment for TTP, to the elucidation of the pathophysiology, the discovery of ADAMTS13, the development of assays a...
Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: Bernhard L ämmle Karen Vanhoorelbeke Johanna A Kremer Hovinga Paul Kn öbl Source Type: research
Petition "Verg ütung für medizinische Leistungen - Verbesserung der Rahmenbedingungen für die ambulante Versorgung", ATMP-QS-Richtlinie Hämophilie und aktueller Stand zur Digitalisierung im Gesundheitswesen: E-Rezept
Hamostaseologie. 2024 Feb;44(1):74-75. doi: 10.1055/a-2177-9429. Epub 2024 Feb 28.NO ABSTRACTPMID:38417805 | DOI:10.1055/a-2177-9429 (Source: Hamostaseologie)
Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: J ürgen Koscielny G ünther Kappert Christoph Sucker Source Type: research
