Geringe α-Thrombin/GPIbα-Interaktion trägt möglicherweise zur Hyperreaktivität der Thrombozyten bei COVID-19-Patienten bei
Hamostaseologie. 2023 Oct;43(5):322-323. doi: 10.1055/s-0043-1776437. Epub 2023 Oct 19.ABSTRACTMEHRERE STUDIEN HABEN GEZEIGT, DASS THROMBOZYTEN MIT DEM SARSCOV-2 CORONAVIRUS INTERAGIEREN KöNNEN. IN DER FOLGE KOMMT ES ZUM PROGRAMMIERTEN ZELLTOD, ZUR FREISETZUNG EXTRAZELLULäRER VESIKEL UND ZU EINER ERHöHTEN THROMBOZYTENREAKTIVITäT BEI PATIENTEN MIT DER CORONAVIRUS-KRANKHEIT-2019 (COVID-19) ALS REAKTION AUF NIEDRIGE DOSEN VON α-THROMBIN.PMID:37857294 | DOI:10.1055/s-0043-1776437 (Source: Hamostaseologie)
Source: Hamostaseologie - October 19, 2023 Category: Hematology Source Type: research
Potentials of Endothelial Colony-Forming Cells: Applications in Hemostasis and Thrombosis Disorders, from Unveiling Disease Pathophysiology to Cell Therapy
Hamostaseologie. 2023 Oct;43(5):325-337. doi: 10.1055/a-2101-5936. Epub 2023 Oct 19.ABSTRACTEndothelial colony-forming cells (ECFCs) are endothelial progenitor cells circulating in a limited number in peripheral blood. They can give rise to mature endothelial cells (ECs) and, with intrinsically high proliferative potency, contribute to forming new blood vessels and restoring the damaged endothelium in vivo. ECFCs can be isolated from peripheral blood or umbilical cord and cultured to generate large amounts of autologous ECs in vitro. Upon differentiation in culture, ECFCs are excellent surrogates for mature ECs showing the...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Nadine Schwarz Hamideh Yadegari Source Type: research
Flow Chamber Analyses in Cardiovascular Research: Impact of Platelets and the Intercellular Crosstalk with Endothelial Cells, Leukocytes, and Red Blood Cells
Hamostaseologie. 2023 Oct;43(5):338-347. doi: 10.1055/a-2113-1134. Epub 2023 Oct 19.ABSTRACTPlatelets are main drivers of thrombus formation. Besides platelet aggregate formation, platelets interact with different blood cells such as red blood and white blood cells (RBCs, WBCs) and endothelial cells (ECs), to promote thrombus formation and inflammation. In the past, the role of different proteins in platelet adhesion, activation, and aggregate formation has been analyzed using platelets/mice with a genetic loss of a certain protein. These knock-out mouse models have been investigated for changes in experimental arterial th...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Kim J ürgen Krott Tobias Feige Margitta Elvers Source Type: research
Intravital Imaging of Thrombosis Models in Mice
Hamostaseologie. 2023 Oct;43(5):348-359. doi: 10.1055/a-2118-2932. Epub 2023 Oct 19.ABSTRACTIntravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of thrombus formation and progression in vivo is studied after inflicting damage to the endothelium through mechanical, chemical, or laser injury. Mouse models of atherosclerosis are also used to induce thrombus formation. Vessels of different sizes and from different vascular beds such as carotid artery or vena cava, mesenteric or cremaster arterioles, can be targeted. Using fluorescent dyes, antibodies, or reporter mouse strains allows to visua...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Klytaimnistra Kiouptsi Martina Casari Jonathan Mandel Zhenling Gao Carsten Deppermann Source Type: research
Runder Tisch zum deutschen H ämophilieregister (DHR), drohender Praxenkollaps, Stand und Zukunft der ambulanten hämostaseologischen Versorgung in Deutschland
Hamostaseologie. 2023 Oct;43(5):374-375. doi: 10.1055/a-2031-7989. Epub 2023 Oct 19.NO ABSTRACTPMID:37857298 | DOI:10.1055/a-2031-7989 (Source: Hamostaseologie)
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: J ürgen Koscielny G ünther Kappert Christoph Sucker Source Type: research
Exposures to fruit plants in Germany from 2010-2019 : Analysis of the Erfurt joint poison information center database
DISCUSSION: Poisoning by fruit plants in Germany is rare. However, there is a great need for information and education.PMID:37828294 | DOI:10.1007/s00103-023-03780-7 (Source: Hamostaseologie)
Source: Hamostaseologie - October 12, 2023 Category: Hematology Authors: Sebastian Wendt Dagmar Prasa Christoph L übbert Kathrin Begemann Heike Franke Source Type: research
Exposures to fruit plants in Germany from 2010-2019 : Analysis of the Erfurt joint poison information center database
DISCUSSION: Poisoning by fruit plants in Germany is rare. However, there is a great need for information and education.PMID:37828294 | DOI:10.1007/s00103-023-03780-7 (Source: Hamostaseologie)
Source: Hamostaseologie - October 12, 2023 Category: Hematology Authors: Sebastian Wendt Dagmar Prasa Christoph L übbert Kathrin Begemann Heike Franke Source Type: research
Exposures to fruit plants in Germany from 2010-2019 : Analysis of the Erfurt joint poison information center database
DISCUSSION: Poisoning by fruit plants in Germany is rare. However, there is a great need for information and education.PMID:37828294 | DOI:10.1007/s00103-023-03780-7 (Source: Hamostaseologie)
Source: Hamostaseologie - October 12, 2023 Category: Hematology Authors: Sebastian Wendt Dagmar Prasa Christoph L übbert Kathrin Begemann Heike Franke Source Type: research
Exposures to fruit plants in Germany from 2010-2019 : Analysis of the Erfurt joint poison information center database
DISCUSSION: Poisoning by fruit plants in Germany is rare. However, there is a great need for information and education.PMID:37828294 | DOI:10.1007/s00103-023-03780-7 (Source: Hamostaseologie)
Source: Hamostaseologie - October 12, 2023 Category: Hematology Authors: Sebastian Wendt Dagmar Prasa Christoph L übbert Kathrin Begemann Heike Franke Source Type: research
Exposures to fruit plants in Germany from 2010-2019 : Analysis of the Erfurt joint poison information center database
DISCUSSION: Poisoning by fruit plants in Germany is rare. However, there is a great need for information and education.PMID:37828294 | DOI:10.1007/s00103-023-03780-7 (Source: Hamostaseologie)
Source: Hamostaseologie - October 12, 2023 Category: Hematology Authors: Sebastian Wendt Dagmar Prasa Christoph L übbert Kathrin Begemann Heike Franke Source Type: research
Exposures to fruit plants in Germany from 2010-2019 : Analysis of the Erfurt joint poison information center database
DISCUSSION: Poisoning by fruit plants in Germany is rare. However, there is a great need for information and education.PMID:37828294 | DOI:10.1007/s00103-023-03780-7 (Source: Hamostaseologie)
Source: Hamostaseologie - October 12, 2023 Category: Hematology Authors: Sebastian Wendt Dagmar Prasa Christoph L übbert Kathrin Begemann Heike Franke Source Type: research
Arterial and Venous Thromboembolic Complications in 832 Patients with BCR-ABL-Negative Myeloproliferative Neoplasms
Hamostaseologie. 2023 Oct 9. doi: 10.1055/a-2159-8767. Online ahead of print.ABSTRACTArterial (ATE) and venous (VTE) thromboembolic complications are common causes of morbidity and mortality in BCR-ABL-negative myeloproliferative neoplasms (MPNs). However, there are few studies that include all MPN subtypes and focus on both MPN-associated ATE and VTE. In our single-center retrospective study of 832 MPN patients, a total of 180 first thromboembolic events occurred during a median follow-up of 6.6 years (range: 0-37.6 years), of which 105 were VTE and 75 were ATE. The probability of a vascular event at the end of the follow...
Source: Hamostaseologie - October 9, 2023 Category: Hematology Authors: Kai Wille Eva Deventer Parvis Sadjadian Tatjana Becker Vera Kolatzki Karlo H ünerbein Raphael Meixner Marina Jim énez-Muñoz Christiane Fuchs Martin Griesshammer Source Type: research
Basics for the Use of Andexanet
This article aims to facilitate the management of patients with andexanet by all medical disciplines involved, thereby ensuring optimal care of patients during bleeding episodes.PMID:37813368 | DOI:10.1055/a-2136-2391 (Source: Hamostaseologie)
Source: Hamostaseologie - October 9, 2023 Category: Hematology Authors: J Koscielny I Birschmann R Bauersachs D Trenk F Langer P M öhnle J Beyer-Westendorf Source Type: research
Arterial and Venous Thromboembolic Complications in 832 Patients with BCR-ABL-Negative Myeloproliferative Neoplasms
Hamostaseologie. 2023 Oct 9. doi: 10.1055/a-2159-8767. Online ahead of print.ABSTRACTArterial (ATE) and venous (VTE) thromboembolic complications are common causes of morbidity and mortality in BCR-ABL-negative myeloproliferative neoplasms (MPNs). However, there are few studies that include all MPN subtypes and focus on both MPN-associated ATE and VTE. In our single-center retrospective study of 832 MPN patients, a total of 180 first thromboembolic events occurred during a median follow-up of 6.6 years (range: 0-37.6 years), of which 105 were VTE and 75 were ATE. The probability of a vascular event at the end of the follow...
Source: Hamostaseologie - October 9, 2023 Category: Hematology Authors: Kai Wille Eva Deventer Parvis Sadjadian Tatjana Becker Vera Kolatzki Karlo H ünerbein Raphael Meixner Marina Jim énez-Muñoz Christiane Fuchs Martin Griesshammer Source Type: research
Basics for the Use of Andexanet
This article aims to facilitate the management of patients with andexanet by all medical disciplines involved, thereby ensuring optimal care of patients during bleeding episodes.PMID:37813368 | DOI:10.1055/a-2136-2391 (Source: Hamostaseologie)
Source: Hamostaseologie - October 9, 2023 Category: Hematology Authors: J Koscielny I Birschmann R Bauersachs D Trenk F Langer P M öhnle J Beyer-Westendorf Source Type: research
