Subsegmental Pulmonary Embolism
Hamostaseologie. 2023 Oct 23. doi: 10.1055/a-2163-3111. Online ahead of print.ABSTRACTSubsegmental pulmonary embolism (SSPE) is increasingly diagnosed with the growing use and technological advancements of multidetector computed tomography pulmonary angiography. Its diagnosis is challenging, and some presumed SSPE may actually represent imaging artifacts. Indirect evidence and results from small observational studies suggest that SSPE may be more benign than more proximal pulmonary embolism, and may thus not always require treatment. Therefore, guidelines suggest to consider a management strategy without anticoagulation in...
Source: Hamostaseologie - October 23, 2023 Category: Hematology Authors: Christine Baumgartner Tobias Tritschler Drahomir Aujesky Source Type: research
Subsegmental Pulmonary Embolism
Hamostaseologie. 2023 Oct 23. doi: 10.1055/a-2163-3111. Online ahead of print.ABSTRACTSubsegmental pulmonary embolism (SSPE) is increasingly diagnosed with the growing use and technological advancements of multidetector computed tomography pulmonary angiography. Its diagnosis is challenging, and some presumed SSPE may actually represent imaging artifacts. Indirect evidence and results from small observational studies suggest that SSPE may be more benign than more proximal pulmonary embolism, and may thus not always require treatment. Therefore, guidelines suggest to consider a management strategy without anticoagulation in...
Source: Hamostaseologie - October 23, 2023 Category: Hematology Authors: Christine Baumgartner Tobias Tritschler Drahomir Aujesky Source Type: research
Subsegmental Pulmonary Embolism
Hamostaseologie. 2023 Oct 23. doi: 10.1055/a-2163-3111. Online ahead of print.ABSTRACTSubsegmental pulmonary embolism (SSPE) is increasingly diagnosed with the growing use and technological advancements of multidetector computed tomography pulmonary angiography. Its diagnosis is challenging, and some presumed SSPE may actually represent imaging artifacts. Indirect evidence and results from small observational studies suggest that SSPE may be more benign than more proximal pulmonary embolism, and may thus not always require treatment. Therefore, guidelines suggest to consider a management strategy without anticoagulation in...
Source: Hamostaseologie - October 23, 2023 Category: Hematology Authors: Christine Baumgartner Tobias Tritschler Drahomir Aujesky Source Type: research
Sharply defined ulcerations of the colon excluding the terminal ileum
Pathologie (Heidelb). 2023 Oct 20. doi: 10.1007/s00292-023-01240-2. Online ahead of print.NO ABSTRACTPMID:37861700 | DOI:10.1007/s00292-023-01240-2 (Source: Hamostaseologie)
Source: Hamostaseologie - October 20, 2023 Category: Hematology Authors: Mirjam Forberger Lena Seidemann Henning Trawinski Hendrik Bl äker Maximilian von Laffert Source Type: research
Sharply defined ulcerations of the colon excluding the terminal ileum
Pathologie (Heidelb). 2023 Oct 20. doi: 10.1007/s00292-023-01240-2. Online ahead of print.NO ABSTRACTPMID:37861700 | DOI:10.1007/s00292-023-01240-2 (Source: Hamostaseologie)
Source: Hamostaseologie - October 20, 2023 Category: Hematology Authors: Mirjam Forberger Lena Seidemann Henning Trawinski Hendrik Bl äker Maximilian von Laffert Source Type: research
Sharply defined ulcerations of the colon excluding the terminal ileum
Pathologie (Heidelb). 2023 Oct 20. doi: 10.1007/s00292-023-01240-2. Online ahead of print.NO ABSTRACTPMID:37861700 | DOI:10.1007/s00292-023-01240-2 (Source: Hamostaseologie)
Source: Hamostaseologie - October 20, 2023 Category: Hematology Authors: Mirjam Forberger Lena Seidemann Henning Trawinski Hendrik Bl äker Maximilian von Laffert Source Type: research
Animal and Cellular Models in Thrombosis and Hemostasis
Hamostaseologie. 2023 Oct;43(5):319-320. doi: 10.1055/a-2031-7975. Epub 2023 Oct 19.ABSTRACTSTANDARDIZED IN VITRO AND IN VIVO MODEL SYSTEMS TO SIMPLIFY COMPLEXITY-THAT'S HOW WE LEARN: The discovery of new target molecules and translational progress in the development and refinement of antithrombotic therapies as well as the improved treatment of bleeding disorders strongly relies on standardized ex vivo and in vivo models that closely resemble the respective human pathologies. The standardization of these models requires sound training in specialized hemostasis and thrombosis research laboratories as well as a consistent d...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Christoph Reinhardt Heiko R ühl Source Type: research
Leichte Schlaganf älle: Thrombolyse und routinemäßige medi-zinische Versorgung im Vergleich
Hamostaseologie. 2023 Oct;43(5):321-322. doi: 10.1055/s-0043-1776436. Epub 2023 Oct 19.ABSTRACTUNGEFäHR 30% DER JäHRLICH NEU AUFTRETENDEN SCHLAGANFäLLE IN CHINA WERDEN ALS LEICHTE ISCHäMISCHE SCHLAGANFäLLE EINGESTUFT. FAST EIN DRITTEL DIESER PATIENTEN SIND DREI MONATE NACH DEM INDEXEREIGNIS ENTWEDER SCHWER BEEINTRäCHTIGT ODER VERSTORBEN. OBWOHL ES KEINEN KLAREN STANDARD FüR DIE VERABREICHUNG EINER THROMBOLYTISCHEN THERAPIE INNERHALB DES 4,5-STUNDEN-FENSTERS GIBT, WURDE IN DEN LETZTEN JAHREN VERMEHRT ALTEPLASE EINGESETZT, UM DAS RISIKO FüR BEEINTRäCHTIGUNGEN NACH EINEM SCHLAGANFALL ZU VERRINGERN.PMID:37857293 | DOI...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Source Type: research
Geringe α-Thrombin/GPIbα-Interaktion trägt möglicherweise zur Hyperreaktivität der Thrombozyten bei COVID-19-Patienten bei
Hamostaseologie. 2023 Oct;43(5):322-323. doi: 10.1055/s-0043-1776437. Epub 2023 Oct 19.ABSTRACTMEHRERE STUDIEN HABEN GEZEIGT, DASS THROMBOZYTEN MIT DEM SARSCOV-2 CORONAVIRUS INTERAGIEREN KöNNEN. IN DER FOLGE KOMMT ES ZUM PROGRAMMIERTEN ZELLTOD, ZUR FREISETZUNG EXTRAZELLULäRER VESIKEL UND ZU EINER ERHöHTEN THROMBOZYTENREAKTIVITäT BEI PATIENTEN MIT DER CORONAVIRUS-KRANKHEIT-2019 (COVID-19) ALS REAKTION AUF NIEDRIGE DOSEN VON α-THROMBIN.PMID:37857294 | DOI:10.1055/s-0043-1776437 (Source: Hamostaseologie)
Source: Hamostaseologie - October 19, 2023 Category: Hematology Source Type: research
Potentials of Endothelial Colony-Forming Cells: Applications in Hemostasis and Thrombosis Disorders, from Unveiling Disease Pathophysiology to Cell Therapy
Hamostaseologie. 2023 Oct;43(5):325-337. doi: 10.1055/a-2101-5936. Epub 2023 Oct 19.ABSTRACTEndothelial colony-forming cells (ECFCs) are endothelial progenitor cells circulating in a limited number in peripheral blood. They can give rise to mature endothelial cells (ECs) and, with intrinsically high proliferative potency, contribute to forming new blood vessels and restoring the damaged endothelium in vivo. ECFCs can be isolated from peripheral blood or umbilical cord and cultured to generate large amounts of autologous ECs in vitro. Upon differentiation in culture, ECFCs are excellent surrogates for mature ECs showing the...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Nadine Schwarz Hamideh Yadegari Source Type: research
Flow Chamber Analyses in Cardiovascular Research: Impact of Platelets and the Intercellular Crosstalk with Endothelial Cells, Leukocytes, and Red Blood Cells
Hamostaseologie. 2023 Oct;43(5):338-347. doi: 10.1055/a-2113-1134. Epub 2023 Oct 19.ABSTRACTPlatelets are main drivers of thrombus formation. Besides platelet aggregate formation, platelets interact with different blood cells such as red blood and white blood cells (RBCs, WBCs) and endothelial cells (ECs), to promote thrombus formation and inflammation. In the past, the role of different proteins in platelet adhesion, activation, and aggregate formation has been analyzed using platelets/mice with a genetic loss of a certain protein. These knock-out mouse models have been investigated for changes in experimental arterial th...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Kim J ürgen Krott Tobias Feige Margitta Elvers Source Type: research
Intravital Imaging of Thrombosis Models in Mice
Hamostaseologie. 2023 Oct;43(5):348-359. doi: 10.1055/a-2118-2932. Epub 2023 Oct 19.ABSTRACTIntravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of thrombus formation and progression in vivo is studied after inflicting damage to the endothelium through mechanical, chemical, or laser injury. Mouse models of atherosclerosis are also used to induce thrombus formation. Vessels of different sizes and from different vascular beds such as carotid artery or vena cava, mesenteric or cremaster arterioles, can be targeted. Using fluorescent dyes, antibodies, or reporter mouse strains allows to visua...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Klytaimnistra Kiouptsi Martina Casari Jonathan Mandel Zhenling Gao Carsten Deppermann Source Type: research
Runder Tisch zum deutschen H ämophilieregister (DHR), drohender Praxenkollaps, Stand und Zukunft der ambulanten hämostaseologischen Versorgung in Deutschland
Hamostaseologie. 2023 Oct;43(5):374-375. doi: 10.1055/a-2031-7989. Epub 2023 Oct 19.NO ABSTRACTPMID:37857298 | DOI:10.1055/a-2031-7989 (Source: Hamostaseologie)
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: J ürgen Koscielny G ünther Kappert Christoph Sucker Source Type: research
Animal and Cellular Models in Thrombosis and Hemostasis
Hamostaseologie. 2023 Oct;43(5):319-320. doi: 10.1055/a-2031-7975. Epub 2023 Oct 19.ABSTRACTSTANDARDIZED IN VITRO AND IN VIVO MODEL SYSTEMS TO SIMPLIFY COMPLEXITY-THAT'S HOW WE LEARN: The discovery of new target molecules and translational progress in the development and refinement of antithrombotic therapies as well as the improved treatment of bleeding disorders strongly relies on standardized ex vivo and in vivo models that closely resemble the respective human pathologies. The standardization of these models requires sound training in specialized hemostasis and thrombosis research laboratories as well as a consistent d...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Authors: Christoph Reinhardt Heiko R ühl Source Type: research
Leichte Schlaganf älle: Thrombolyse und routinemäßige medi-zinische Versorgung im Vergleich
Hamostaseologie. 2023 Oct;43(5):321-322. doi: 10.1055/s-0043-1776436. Epub 2023 Oct 19.ABSTRACTUNGEFäHR 30% DER JäHRLICH NEU AUFTRETENDEN SCHLAGANFäLLE IN CHINA WERDEN ALS LEICHTE ISCHäMISCHE SCHLAGANFäLLE EINGESTUFT. FAST EIN DRITTEL DIESER PATIENTEN SIND DREI MONATE NACH DEM INDEXEREIGNIS ENTWEDER SCHWER BEEINTRäCHTIGT ODER VERSTORBEN. OBWOHL ES KEINEN KLAREN STANDARD FüR DIE VERABREICHUNG EINER THROMBOLYTISCHEN THERAPIE INNERHALB DES 4,5-STUNDEN-FENSTERS GIBT, WURDE IN DEN LETZTEN JAHREN VERMEHRT ALTEPLASE EINGESETZT, UM DAS RISIKO FüR BEEINTRäCHTIGUNGEN NACH EINEM SCHLAGANFALL ZU VERRINGERN.PMID:37857293 | DOI...
Source: Hamostaseologie - October 19, 2023 Category: Hematology Source Type: research
