Reshaping Anticoagulation: Factor XI Inhibition in Thrombosis Management
Hamostaseologie. 2023 Dec 20. doi: 10.1055/a-2202-8620. Online ahead of print.ABSTRACTFactor XI is almost dispensable for haemostasis, but its role in thrombosis has become increasingly clear. Targeting factor XI could potentially prevent thrombosis with little or no effect on haemostasis. This review explains the underlying mechanisms of thrombosis and haemostasis and elucidates the rationale for factor XI inhibitors based on the pathophysiology and epidemiological and pre-clinical data. It further outlines the different modes for factor XI inhibition. Finally, the article provides an overview of the current clinical evid...
Source: Hamostaseologie - December 20, 2023 Category: Hematology Authors: Andreas Verstraete Matthias M Engelen Charlotte Van Edom Thomas Vanassche Peter Verhamme Source Type: research
Reshaping Anticoagulation: Factor XI Inhibition in Thrombosis Management
Hamostaseologie. 2023 Dec 20. doi: 10.1055/a-2202-8620. Online ahead of print.ABSTRACTFactor XI is almost dispensable for haemostasis, but its role in thrombosis has become increasingly clear. Targeting factor XI could potentially prevent thrombosis with little or no effect on haemostasis. This review explains the underlying mechanisms of thrombosis and haemostasis and elucidates the rationale for factor XI inhibitors based on the pathophysiology and epidemiological and pre-clinical data. It further outlines the different modes for factor XI inhibition. Finally, the article provides an overview of the current clinical evid...
Source: Hamostaseologie - December 20, 2023 Category: Hematology Authors: Andreas Verstraete Matthias M Engelen Charlotte Van Edom Thomas Vanassche Peter Verhamme Source Type: research
Reshaping Anticoagulation: Factor XI Inhibition in Thrombosis Management
Hamostaseologie. 2023 Dec 20. doi: 10.1055/a-2202-8620. Online ahead of print.ABSTRACTFactor XI is almost dispensable for haemostasis, but its role in thrombosis has become increasingly clear. Targeting factor XI could potentially prevent thrombosis with little or no effect on haemostasis. This review explains the underlying mechanisms of thrombosis and haemostasis and elucidates the rationale for factor XI inhibitors based on the pathophysiology and epidemiological and pre-clinical data. It further outlines the different modes for factor XI inhibition. Finally, the article provides an overview of the current clinical evid...
Source: Hamostaseologie - December 20, 2023 Category: Hematology Authors: Andreas Verstraete Matthias M Engelen Charlotte Van Edom Thomas Vanassche Peter Verhamme Source Type: research
Reshaping Anticoagulation: Factor XI Inhibition in Thrombosis Management
Hamostaseologie. 2023 Dec 20. doi: 10.1055/a-2202-8620. Online ahead of print.ABSTRACTFactor XI is almost dispensable for haemostasis, but its role in thrombosis has become increasingly clear. Targeting factor XI could potentially prevent thrombosis with little or no effect on haemostasis. This review explains the underlying mechanisms of thrombosis and haemostasis and elucidates the rationale for factor XI inhibitors based on the pathophysiology and epidemiological and pre-clinical data. It further outlines the different modes for factor XI inhibition. Finally, the article provides an overview of the current clinical evid...
Source: Hamostaseologie - December 20, 2023 Category: Hematology Authors: Andreas Verstraete Matthias M Engelen Charlotte Van Edom Thomas Vanassche Peter Verhamme Source Type: research
Aggregates of non-muscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia
CONCLUSIONS: Aggregates of NMMIIA in the erythrocytes associate with GATA1-RT and GFI1B-RT and can facilitate their diagnosis on the blood smears. This hitherto unreported finding might represent a novel marker of dyserythropoiesis assessable in peripheral blood.PMID:38103735 | DOI:10.1016/j.jtha.2023.12.007 (Source: Hamostaseologie)
Source: Hamostaseologie - December 16, 2023 Category: Hematology Authors: Carlo Zaninetti Jose' Rivera Leonard Vater Sandra Ohlenforst Eva Lein øe Doris B öckelmann Kathleen Freson Thomas Thiele Houssain Makhloufi Matthias Rath Wolfgang Eberl Martina Wolff Carmen Freyer Jan Wesche Barbara Zieger Ute Felbor Florian H Heidel An Source Type: research
Aggregates of non-muscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia
CONCLUSIONS: Aggregates of NMMIIA in the erythrocytes associate with GATA1-RT and GFI1B-RT and can facilitate their diagnosis on the blood smears. This hitherto unreported finding might represent a novel marker of dyserythropoiesis assessable in peripheral blood.PMID:38103735 | DOI:10.1016/j.jtha.2023.12.007 (Source: Hamostaseologie)
Source: Hamostaseologie - December 16, 2023 Category: Hematology Authors: Carlo Zaninetti Jose' Rivera Leonard Vater Sandra Ohlenforst Eva Lein øe Doris B öckelmann Kathleen Freson Thomas Thiele Houssain Makhloufi Matthias Rath Wolfgang Eberl Martina Wolff Carmen Freyer Jan Wesche Barbara Zieger Ute Felbor Florian H Heidel An Source Type: research
Aggregates of non-muscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia
CONCLUSIONS: Aggregates of NMMIIA in the erythrocytes associate with GATA1-RT and GFI1B-RT and can facilitate their diagnosis on the blood smears. This hitherto unreported finding might represent a novel marker of dyserythropoiesis assessable in peripheral blood.PMID:38103735 | DOI:10.1016/j.jtha.2023.12.007 (Source: Hamostaseologie)
Source: Hamostaseologie - December 16, 2023 Category: Hematology Authors: Carlo Zaninetti Jose' Rivera Leonard Vater Sandra Ohlenforst Eva Lein øe Doris B öckelmann Kathleen Freson Thomas Thiele Houssain Makhloufi Matthias Rath Wolfgang Eberl Martina Wolff Carmen Freyer Jan Wesche Barbara Zieger Ute Felbor Florian H Heidel An Source Type: research
Aggregates of non-muscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia
CONCLUSIONS: Aggregates of NMMIIA in the erythrocytes associate with GATA1-RT and GFI1B-RT and can facilitate their diagnosis on the blood smears. This hitherto unreported finding might represent a novel marker of dyserythropoiesis assessable in peripheral blood.PMID:38103735 | DOI:10.1016/j.jtha.2023.12.007 (Source: Hamostaseologie)
Source: Hamostaseologie - December 16, 2023 Category: Hematology Authors: Carlo Zaninetti Jose' Rivera Leonard Vater Sandra Ohlenforst Eva Lein øe Doris B öckelmann Kathleen Freson Thomas Thiele Houssain Makhloufi Matthias Rath Wolfgang Eberl Martina Wolff Carmen Freyer Jan Wesche Barbara Zieger Ute Felbor Florian H Heidel An Source Type: research
Postexposure prophylaxis after bite of a broad-winged bat with evidence of European bat lyssavirus 1 (EBLV-1)
We report on a patient who suffered a bat bite in an urban setting in which European bat lyssavirus 1 (EBLV-1) was detected in the euthanized bat. We performed active and passive postexposure prophylaxis (PEP). This case study illustrates the ongoing risk of rabies infection due to close bat contacts in Germany and is intended to sensitize primary care physicians to take such exposure events seriously and to perform a regular PEP including administration of rabies immunoglobulin.PMID:38100072 | DOI:10.1007/s00108-023-01638-3 (Source: Hamostaseologie)
Source: Hamostaseologie - December 15, 2023 Category: Hematology Authors: Jannik Fasse Henning Trawinski Michael Hardt Christoph L übbert Source Type: research
Postexposure prophylaxis after bite of a broad-winged bat with evidence of European bat lyssavirus 1 (EBLV-1)
We report on a patient who suffered a bat bite in an urban setting in which European bat lyssavirus 1 (EBLV-1) was detected in the euthanized bat. We performed active and passive postexposure prophylaxis (PEP). This case study illustrates the ongoing risk of rabies infection due to close bat contacts in Germany and is intended to sensitize primary care physicians to take such exposure events seriously and to perform a regular PEP including administration of rabies immunoglobulin.PMID:38100072 | DOI:10.1007/s00108-023-01638-3 (Source: Hamostaseologie)
Source: Hamostaseologie - December 15, 2023 Category: Hematology Authors: Jannik Fasse Henning Trawinski Michael Hardt Christoph L übbert Source Type: research
Potenzielle globale Gerinnungsparameter f ür Therapiemonitoring unter Emicizumab
Hamostaseologie. 2023 Dec;43(6):394. doi: 10.1055/s-0043-1777816. Epub 2023 Dec 14.ABSTRACTWäHREND DIE BEHANDLUNG DER GENETISCH BEDINGTEN GERINNUNGSSTöRUNG HäMOPHILIE A IN DER VERGANGENHEIT IN REGELMäßIGEN INTRAVENöSEN FAKTOR-VIII-INFUSIONEN BESTAND, STEHT HEUTE MIT DEM ANTIKöRPER EMICIZUMAB EINE EFFEKTIVE ALTERNATIVE ZUR SUBKUTANEN APPLIKATION ZUR VERFüGUNG. BISHER FEHLEN ALLERDINGS PARAMETER, MIT DENEN SICH DAS AUSMAß DER GERINNUNGSKORREKTUR BEIM EINZELNEN PATIENTEN VERLäSSLICH ABBILDEN LäSST. IN EINER AKTUELLEN STUDIE KRISTALLISIERTEN SICH JETZT ZWEI GLOBALE GERINNUNGSPARAMETER HERAUS, MIT DENEN EIN SOLCHES M...
Source: Hamostaseologie - December 14, 2023 Category: Hematology Source Type: research
Marker der Akute-Phase-Reaktion k önnten Blutungen bei Hämophilie detektieren
Hamostaseologie. 2023 Dec;43(6):396. doi: 10.1055/s-0043-1777817. Epub 2023 Dec 14.ABSTRACTBEI DER HäMOPHILIE A UND B WERDEN IM RAHMEN VON AKUTEN HäMORRHAGIEN ENTZüNDUNGSREAKTIONEN AUSGELöST. SIND GELENKE VON DEN BLUTUNGEN BETROFFEN, KANN HIERAUS DIE SO GENANNTE HäMOPHILE ARTHROPATHIE RESULTIEREN. IN EINER AKTUELLEN STUDIE WURDEN JETZT PATIENTEN MIT HäMOPHILIE IM HINBLICK AUF MARKER DER AKUTE-PHASE-REAKTION UNTERSUCHT. DARüBER HINAUS WURDE EIN TIERMODELL ETABLIERT.PMID:38096833 | DOI:10.1055/s-0043-1777817 (Source: Hamostaseologie)
Source: Hamostaseologie - December 14, 2023 Category: Hematology Source Type: research
GTH News
Hamostaseologie. 2023 Dec;43(6):449-453. doi: 10.1055/s-0043-1777814. Epub 2023 Dec 14.NO ABSTRACTPMID:38096834 | DOI:10.1055/s-0043-1777814 (Source: Hamostaseologie)
Source: Hamostaseologie - December 14, 2023 Category: Hematology Source Type: research
Programm f ür die Veranstaltung des BDDH im Rahmen der 68. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung in Wien 2024 und Petition an den Deutschen Bundestag aufgrund eines drohenden Praxenkollaps
Hamostaseologie. 2023 Dec;43(6):454-455. doi: 10.1055/a-2031-8165. Epub 2023 Dec 14.NO ABSTRACTPMID:38096835 | DOI:10.1055/a-2031-8165 (Source: Hamostaseologie)
Source: Hamostaseologie - December 14, 2023 Category: Hematology Authors: J ürgen Koscielny G ünther Kappert Christoph Sucker Source Type: research
Erratum: A Novel Fibrinogen Mutation p.B βAla68Asp Causes an Inherited Dysfibrinogenemia
Hamostaseologie. 2023 Dec;43(6):e1. doi: 10.1055/a-2218-6919. Epub 2023 Dec 14.NO ABSTRACTPMID:38096836 | DOI:10.1055/a-2218-6919 (Source: Hamostaseologie)
Source: Hamostaseologie - December 14, 2023 Category: Hematology Authors: Kaiqi Jia Manlin Zeng Xiaoyong Zheng Haixiao Xie Lihong Yang Yaosheng Xie Mingshan Wang Source Type: research
