With a tumor diagnosis in the intensive care unit
Inn Med (Heidelb). 2023 Sep 20. doi: 10.1007/s00108-023-01583-1. Online ahead of print.ABSTRACTTumor patients nowadays show significantly improved survival rates due to advancements in modern intensive care medicine, particularly in the case of organ failure. The previous reluctance towards implementing intensive medical care measures in patients with a tumorous disease is no longer justified. For successful intensive care treatment, the timing and the mode of admission along with the specific intensive care measures and underlying organ dysfunction(s) are crucial factors for the prognosis. To ensure appropriate treatment ...
Source: Hamostaseologie - September 20, 2023 Category: Hematology Authors: Gernot Beutel Tobias Liebregts Boris B öll Source Type: research
Clinical Characterization and Molecular Analysis of Fourteen Chinese Patients with Factor V Deficiency
CONCLUSION: This is the largest genetic analysis of a single cohort of FV deficiency in Chinese. The study demonstrated that FV levels tended to be correlated with the probability of hemorrhage. The identification of a large number of unique FV-deficient pedigrees highlighted the screening for mutations in F5.PMID:37714176 | DOI:10.1055/a-2146-9540 (Source: Hamostaseologie)
Source: Hamostaseologie - September 15, 2023 Category: Hematology Authors: Ke Zhang Longying Ye Yanhui Jin Yuan Chen Manlin Zeng Kaiqi Jia Lihong Yang Mingshan Wang Source Type: research
Clinical Characterization and Molecular Analysis of Fourteen Chinese Patients with Factor V Deficiency
CONCLUSION: This is the largest genetic analysis of a single cohort of FV deficiency in Chinese. The study demonstrated that FV levels tended to be correlated with the probability of hemorrhage. The identification of a large number of unique FV-deficient pedigrees highlighted the screening for mutations in F5.PMID:37714176 | DOI:10.1055/a-2146-9540 (Source: Hamostaseologie)
Source: Hamostaseologie - September 15, 2023 Category: Hematology Authors: Ke Zhang Longying Ye Yanhui Jin Yuan Chen Manlin Zeng Kaiqi Jia Lihong Yang Mingshan Wang Source Type: research
Clinical Characterization and Molecular Analysis of Fourteen Chinese Patients with Factor V Deficiency
CONCLUSION: This is the largest genetic analysis of a single cohort of FV deficiency in Chinese. The study demonstrated that FV levels tended to be correlated with the probability of hemorrhage. The identification of a large number of unique FV-deficient pedigrees highlighted the screening for mutations in F5.PMID:37714176 | DOI:10.1055/a-2146-9540 (Source: Hamostaseologie)
Source: Hamostaseologie - September 15, 2023 Category: Hematology Authors: Ke Zhang Longying Ye Yanhui Jin Yuan Chen Manlin Zeng Kaiqi Jia Lihong Yang Mingshan Wang Source Type: research
Clinical Characterization and Molecular Analysis of Fourteen Chinese Patients with Factor V Deficiency
CONCLUSION: This is the largest genetic analysis of a single cohort of FV deficiency in Chinese. The study demonstrated that FV levels tended to be correlated with the probability of hemorrhage. The identification of a large number of unique FV-deficient pedigrees highlighted the screening for mutations in F5.PMID:37714176 | DOI:10.1055/a-2146-9540 (Source: Hamostaseologie)
Source: Hamostaseologie - September 15, 2023 Category: Hematology Authors: Ke Zhang Longying Ye Yanhui Jin Yuan Chen Manlin Zeng Kaiqi Jia Lihong Yang Mingshan Wang Source Type: research
The Use of Large Animal Models in Trauma and Bleeding Studies
CONCLUSIONS: Recognizing the diverse strengths and weaknesses of large animal models is critical for trauma and hemorrhage research. Each model is unique and should be chosen based on how well it aligns with the specific scientific objectives of the study. By strategically considering each model's advantages and limitations, we can enhance our understanding of trauma and hemorrhage pathophysiology and further advance the development of effective treatments.PMID:37696297 | DOI:10.1055/a-2118-1431 (Source: Hamostaseologie)
Source: Hamostaseologie - September 11, 2023 Category: Hematology Authors: Farahnaz Rayatdoost Oliver Grottke Source Type: research
The Use of Large Animal Models in Trauma and Bleeding Studies
CONCLUSIONS: Recognizing the diverse strengths and weaknesses of large animal models is critical for trauma and hemorrhage research. Each model is unique and should be chosen based on how well it aligns with the specific scientific objectives of the study. By strategically considering each model's advantages and limitations, we can enhance our understanding of trauma and hemorrhage pathophysiology and further advance the development of effective treatments.PMID:37696297 | DOI:10.1055/a-2118-1431 (Source: Hamostaseologie)
Source: Hamostaseologie - September 11, 2023 Category: Hematology Authors: Farahnaz Rayatdoost Oliver Grottke Source Type: research
The Use of Large Animal Models in Trauma and Bleeding Studies
CONCLUSIONS: Recognizing the diverse strengths and weaknesses of large animal models is critical for trauma and hemorrhage research. Each model is unique and should be chosen based on how well it aligns with the specific scientific objectives of the study. By strategically considering each model's advantages and limitations, we can enhance our understanding of trauma and hemorrhage pathophysiology and further advance the development of effective treatments.PMID:37696297 | DOI:10.1055/a-2118-1431 (Source: Hamostaseologie)
Source: Hamostaseologie - September 11, 2023 Category: Hematology Authors: Farahnaz Rayatdoost Oliver Grottke Source Type: research
The Use of Large Animal Models in Trauma and Bleeding Studies
CONCLUSIONS: Recognizing the diverse strengths and weaknesses of large animal models is critical for trauma and hemorrhage research. Each model is unique and should be chosen based on how well it aligns with the specific scientific objectives of the study. By strategically considering each model's advantages and limitations, we can enhance our understanding of trauma and hemorrhage pathophysiology and further advance the development of effective treatments.PMID:37696297 | DOI:10.1055/a-2118-1431 (Source: Hamostaseologie)
Source: Hamostaseologie - September 11, 2023 Category: Hematology Authors: Farahnaz Rayatdoost Oliver Grottke Source Type: research
Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research
Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research
Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research
Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research
Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research
Nachtrag zur kritischen Diskussion über das Deutsche Hämophilieregister (DHR) anlässlich der GTH-Jahrestagung in Frankfurt 2023, aktuelle Informationen zur Gefährdung der Versorgung mit Blutplasmaprodukten und Aus für Siemens Atellica in Deutschland
Hamostaseologie. 2023 Aug;43(4):306-308. doi: 10.1055/a-2031-7804. Epub 2023 Aug 31.NO ABSTRACTPMID:37652075 | DOI:10.1055/a-2031-7804 (Source: Hamostaseologie)
Source: Hamostaseologie - August 31, 2023 Category: Hematology Authors: J ürgen Koscielny G ünther Kappert Christoph Sucker Source Type: research
