Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Exosome complex components 1 and 2 are vital for early mammalian development
Gene Expr Patterns. 2023 Nov 6:119346. doi: 10.1016/j.gep.2023.119346. Online ahead of print.ABSTRACTExosome Complex Components 1 and 2 (EXOSC1 and 2) are two proteins in the RNA Exosome complex whose main function is 5' → 3' RNA degradation and processing. The RNA exosome complex is comprised of nine subunits that form two separate components: the S1/KH cap and the PH-core. EXOSC1 and 2 are both part of the S1/KH cap and are involved in binding nascent RNA. As part of a systemic characterization of early lethal alleles produced by the Knockout Mouse Project, we have examined Exosc1 and Exosc2 homozygous null (mutant) em...
Source: Gene Expression Patterns : GEP - November 8, 2023 Category: Genetics & Stem Cells Authors: Sanjana Srinivasan Xinjian He Sarah Mirza Jesse Mager Source Type: research
Cell adhesion marker expression dynamics during fusion of the optic fissure
Gene Expr Patterns. 2023 Oct 14;50:119344. doi: 10.1016/j.gep.2023.119344. Online ahead of print.ABSTRACTTissue fusion is a critical process that is repeated in multiple contexts during embryonic development and shares common attributes to processes such as wound healing and metastasis. Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness. Coloboma results from fusion failure between opposing ventral retinal epithelia, but there are major knowledge gaps in our understanding of this process at the molecular and cell behavioural levels...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Holly Hardy Joe Rainger Source Type: research
Developmental expression of peroxiredoxin gene family in early embryonic development of Xenopus tropicalis
This study investigated the spatiotemporal expression patterns of gene members in this family during the early development of Xenopus tropicalis. Real-time quantitative PCR showed that all members of this gene family have a distinct temporal expression pattern during the early development of X. tropicalis embryos. Additionally, whole mount in situ hybridization revealed that individual prdx genes display differential expression patterns, with overlapping expression in lymphatic vessels, pronephros, proximal tubule, and branchial arches. This study provides a basis for further study of the function of the prdx gene family.P...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Linke Zhong Tingting Fu Chengdong Wang Xufeng Qi Wai-Yee Chan Dongqing Cai Hui Zhao Source Type: research
Cell adhesion marker expression dynamics during fusion of the optic fissure
Gene Expr Patterns. 2023 Oct 14;50:119344. doi: 10.1016/j.gep.2023.119344. Online ahead of print.ABSTRACTTissue fusion is a critical process that is repeated in multiple contexts during embryonic development and shares common attributes to processes such as wound healing and metastasis. Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness. Coloboma results from fusion failure between opposing ventral retinal epithelia, but there are major knowledge gaps in our understanding of this process at the molecular and cell behavioural levels...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Holly Hardy Joe Rainger Source Type: research
Developmental expression of peroxiredoxin gene family in early embryonic development of Xenopus tropicalis
This study investigated the spatiotemporal expression patterns of gene members in this family during the early development of Xenopus tropicalis. Real-time quantitative PCR showed that all members of this gene family have a distinct temporal expression pattern during the early development of X. tropicalis embryos. Additionally, whole mount in situ hybridization revealed that individual prdx genes display differential expression patterns, with overlapping expression in lymphatic vessels, pronephros, proximal tubule, and branchial arches. This study provides a basis for further study of the function of the prdx gene family.P...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Linke Zhong Tingting Fu Chengdong Wang Xufeng Qi Wai-Yee Chan Dongqing Cai Hui Zhao Source Type: research
Cell adhesion marker expression dynamics during fusion of the optic fissure
Gene Expr Patterns. 2023 Oct 14;50:119344. doi: 10.1016/j.gep.2023.119344. Online ahead of print.ABSTRACTTissue fusion is a critical process that is repeated in multiple contexts during embryonic development and shares common attributes to processes such as wound healing and metastasis. Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness. Coloboma results from fusion failure between opposing ventral retinal epithelia, but there are major knowledge gaps in our understanding of this process at the molecular and cell behavioural levels...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Holly Hardy Joe Rainger Source Type: research
Developmental expression of peroxiredoxin gene family in early embryonic development of Xenopus tropicalis
This study investigated the spatiotemporal expression patterns of gene members in this family during the early development of Xenopus tropicalis. Real-time quantitative PCR showed that all members of this gene family have a distinct temporal expression pattern during the early development of X. tropicalis embryos. Additionally, whole mount in situ hybridization revealed that individual prdx genes display differential expression patterns, with overlapping expression in lymphatic vessels, pronephros, proximal tubule, and branchial arches. This study provides a basis for further study of the function of the prdx gene family.P...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Linke Zhong Tingting Fu Chengdong Wang Xufeng Qi Wai-Yee Chan Dongqing Cai Hui Zhao Source Type: research
Cell adhesion marker expression dynamics during fusion of the optic fissure
Gene Expr Patterns. 2023 Oct 14;50:119344. doi: 10.1016/j.gep.2023.119344. Online ahead of print.ABSTRACTTissue fusion is a critical process that is repeated in multiple contexts during embryonic development and shares common attributes to processes such as wound healing and metastasis. Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness. Coloboma results from fusion failure between opposing ventral retinal epithelia, but there are major knowledge gaps in our understanding of this process at the molecular and cell behavioural levels...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Holly Hardy Joe Rainger Source Type: research
Developmental expression of peroxiredoxin gene family in early embryonic development of Xenopus tropicalis
This study investigated the spatiotemporal expression patterns of gene members in this family during the early development of Xenopus tropicalis. Real-time quantitative PCR showed that all members of this gene family have a distinct temporal expression pattern during the early development of X. tropicalis embryos. Additionally, whole mount in situ hybridization revealed that individual prdx genes display differential expression patterns, with overlapping expression in lymphatic vessels, pronephros, proximal tubule, and branchial arches. This study provides a basis for further study of the function of the prdx gene family.P...
Source: Gene Expression Patterns : GEP - October 16, 2023 Category: Genetics & Stem Cells Authors: Linke Zhong Tingting Fu Chengdong Wang Xufeng Qi Wai-Yee Chan Dongqing Cai Hui Zhao Source Type: research
