hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4;48:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localizatio...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4;48:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localizatio...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4;48:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localizatio...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4;48:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localizatio...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4;48:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localizatio...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4;48:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localizatio...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
hnRNPL expression dynamics in the embryo and placenta
Gene Expr Patterns. 2023 May 4:119319. doi: 10.1016/j.gep.2023.119319. Online ahead of print.ABSTRACTHeterogeneous nuclear ribonucleoprotein L (hnRNPL) is a conserved RNA binding protein (RBP) that plays an important role in the alternative splicing of gene transcripts, and thus in the generation of specific protein isoforms. Global deficiency in hnRNPL in mice results in preimplantation embryonic lethality at embryonic day (E) 3.5. To begin to understand the contribution of hnRNPL-regulated pathways in the normal development of the embryo and placenta, we determined hnRNPL expression profile and subcellular localization t...
Source: Gene Expression Patterns : GEP - May 6, 2023 Category: Genetics & Stem Cells Authors: Vineetha Mathew Ariel Mei Hamida Giwa Agnes Cheong Ashmita Chander Aaron Zou Robert M Blanton Olga Kashpur Wei Cui Donna Slonim Taysir Mahmoud Perrie O'Tierney-Ginn Jesse Mager Isabelle Draper Mary C Wallingford Source Type: research
Identification of novel candidate genes leading to sex differentiation in primordial germ cells of Drosophila
Gene Expr Patterns. 2023 May 2:119321. doi: 10.1016/j.gep.2023.119321. Online ahead of print.ABSTRACTGermline sex determination and differentiation are pivotal processes in reproduction. In Drosophila, sex determination of the germline occurs in primordial germ cells (PGCs), and the sex differentiation of these cells is initiated during embryogenesis. However, the molecular mechanism initiating sex differentiation remains elusive. To address this issue, we identified sex-biased genes using RNA-sequencing data of male and female PGCs. Our research revealed 497 genes that were differentially expressed more than twofold betwe...
Source: Gene Expression Patterns : GEP - May 4, 2023 Category: Genetics & Stem Cells Authors: Ryoma Ota Hiroki Miura Masaki Masukawa Makoto Hayashi Satoru Kobayashi Source Type: research
Identification of novel candidate genes leading to sex differentiation in primordial germ cells of Drosophila
Gene Expr Patterns. 2023 May 2:119321. doi: 10.1016/j.gep.2023.119321. Online ahead of print.ABSTRACTGermline sex determination and differentiation are pivotal processes in reproduction. In Drosophila, sex determination of the germline occurs in primordial germ cells (PGCs), and the sex differentiation of these cells is initiated during embryogenesis. However, the molecular mechanism initiating sex differentiation remains elusive. To address this issue, we identified sex-biased genes using RNA-sequencing data of male and female PGCs. Our research revealed 497 genes that were differentially expressed more than twofold betwe...
Source: Gene Expression Patterns : GEP - May 4, 2023 Category: Genetics & Stem Cells Authors: Ryoma Ota Hiroki Miura Masaki Masukawa Makoto Hayashi Satoru Kobayashi Source Type: research
