CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 29;49:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 tec...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
CRISPR/Cas9-induced asap1a and asap1b co-knockout mutant zebrafish displayed abnormal embryonic development and impaired neutrophil migration
Gene Expr Patterns. 2023 Jun 28:119331. doi: 10.1016/j.gep.2023.119331. Online ahead of print.ABSTRACTASAP1 (Arf-GAP with SH3 domain, the ankyrin repeat and the PH domain) is the GTPase activating protein of the small G protein Arf. To understand more about the physiological functions of ASAP1 in vivo, we chose to use the zebrafish as an animal model, and analyzed the characterization of asap1 using loss-of-function studies. Here, two isoforms in zebrafish, asap1a and asap1b, were found to be homologous to human ASAP1, and the gene knockout zebrafish lines for asap1a and asap1b were established using the CRISPR/Cas9 techni...
Source: Gene Expression Patterns : GEP - June 30, 2023 Category: Genetics & Stem Cells Authors: Cui Jia Da Wen Liqing Wang Chaoqun Meng Yuhuan Wang Zhonghua Zhao Changxin Wu Source Type: research
