Feasibility analysis of intrathecal administration strategy of nusinersen based on Cobb angle in children with spinal muscular atrophy
CONCLUSION: Cobb angle is an important basis for intrathecal administration of nusinersen. It is feasible and suitable to carry out intrathecal nusinersen injection under ultrasound combined with three-dimensional CT imaging for children with severe scoliosis.PMID:37453233 | DOI:10.1016/j.ejpn.2023.06.010 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 15, 2023 Category: Neurology Authors: Jinjin Huang Yijie Feng Jia Wang Siyi Huang Jianing Jin Lu Xu Congying Zhao Yi Hua Xiaoying Li Jingfang Xu Haibing Li Huan Zhang Yi Zhang Feng Gao Shanshan Mao Source Type: research

Feasibility analysis of intrathecal administration strategy of nusinersen based on Cobb angle in children with spinal muscular atrophy
CONCLUSION: Cobb angle is an important basis for intrathecal administration of nusinersen. It is feasible and suitable to carry out intrathecal nusinersen injection under ultrasound combined with three-dimensional CT imaging for children with severe scoliosis.PMID:37453233 | DOI:10.1016/j.ejpn.2023.06.010 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 15, 2023 Category: Neurology Authors: Jinjin Huang Yijie Feng Jia Wang Siyi Huang Jianing Jin Lu Xu Congying Zhao Yi Hua Xiaoying Li Jingfang Xu Haibing Li Huan Zhang Yi Zhang Feng Gao Shanshan Mao Source Type: research

Unravelling key pathways in childhood ataxia to guide diagnosis and treatment
Eur J Paediatr Neurol. 2023 Jul 6:S1090-3798(23)00103-4. doi: 10.1016/j.ejpn.2023.07.001. Online ahead of print.NO ABSTRACTPMID:37433712 | DOI:10.1016/j.ejpn.2023.07.001 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 11, 2023 Category: Neurology Authors: Andreas Brunklaus Source Type: research

Unravelling key pathways in childhood ataxia to guide diagnosis and treatment
Eur J Paediatr Neurol. 2023 Jul 6:S1090-3798(23)00103-4. doi: 10.1016/j.ejpn.2023.07.001. Online ahead of print.NO ABSTRACTPMID:37433712 | DOI:10.1016/j.ejpn.2023.07.001 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 11, 2023 Category: Neurology Authors: Andreas Brunklaus Source Type: research

Unravelling key pathways in childhood ataxia to guide diagnosis and treatment
Eur J Paediatr Neurol. 2023 Jul 6:S1090-3798(23)00103-4. doi: 10.1016/j.ejpn.2023.07.001. Online ahead of print.NO ABSTRACTPMID:37433712 | DOI:10.1016/j.ejpn.2023.07.001 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 11, 2023 Category: Neurology Authors: Andreas Brunklaus Source Type: research

Unravelling key pathways in childhood ataxia to guide diagnosis and treatment
Eur J Paediatr Neurol. 2023 Jul 6:S1090-3798(23)00103-4. doi: 10.1016/j.ejpn.2023.07.001. Online ahead of print.NO ABSTRACTPMID:37433712 | DOI:10.1016/j.ejpn.2023.07.001 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 11, 2023 Category: Neurology Authors: Andreas Brunklaus Source Type: research

CCL2/MCP-1, interleukin-8, and fractalkine/CXC3CL1: Potential biomarkers of epileptogenesis and pharmacoresistance in childhood epilepsy
CONCLUSION: Elevated CCL2/MCP-1 in CSF and plasma, elevated levels of fractalkine/CXC3CL1 in CSF, and a trend toward elevated IL-8 in the CSF of patients with pharmacoresistant epilepsy indicate these cytokines as potential biomarkers of epileptogenesis and pharmacoresistance. CCL2/MCP-1was detected in blood plasma; this assessment may be easily achieved in clinical practice without the invasiveness of a spinal tap. However, due to the complexity of neuroinflammation in epilepsy, further studies are warranted to confirm our findings.PMID:37429062 | DOI:10.1016/j.ejpn.2023.06.001 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 10, 2023 Category: Neurology Authors: Katar ína Česká Jan Pape ž Hana O šlejšková Ond řej Slabý Lenka Radov á Tom áš Loja Zuzana Lib á Anna Sv ěráková Milan Br ázdil Štefánia Aulická Source Type: research

CCL2/MCP-1, interleukin-8, and fractalkine/CXC3CL1: Potential biomarkers of epileptogenesis and pharmacoresistance in childhood epilepsy
CONCLUSION: Elevated CCL2/MCP-1 in CSF and plasma, elevated levels of fractalkine/CXC3CL1 in CSF, and a trend toward elevated IL-8 in the CSF of patients with pharmacoresistant epilepsy indicate these cytokines as potential biomarkers of epileptogenesis and pharmacoresistance. CCL2/MCP-1was detected in blood plasma; this assessment may be easily achieved in clinical practice without the invasiveness of a spinal tap. However, due to the complexity of neuroinflammation in epilepsy, further studies are warranted to confirm our findings.PMID:37429062 | DOI:10.1016/j.ejpn.2023.06.001 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 10, 2023 Category: Neurology Authors: Katar ína Česká Jan Pape ž Hana O šlejšková Ond řej Slabý Lenka Radov á Tom áš Loja Zuzana Lib á Anna Sv ěráková Milan Br ázdil Štefánia Aulická Source Type: research

Psychological test usage in duchenne muscular dystrophy: An EU multi-centre study
CONCLUSION: The heterogeneity of tests and diagnoses being used in current clinical practice underlines the importance for developing a Standard Operating Procedure (SOP) to improve both clinical practice and scientific research over different countries and improve comparative work.PMID:37423006 | DOI:10.1016/j.ejpn.2023.06.007 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 9, 2023 Category: Neurology Authors: Pien Weerkamp Daniela Chieffo Philippe Collin Federica Moriconi Andriani Papageorgiou Isabella Vainieri Ruben Miranda Catherine Hankinson Asmus Vogel Sarah Poncet Catherine Moss Francesco Muntoni Eugenio Mercuri Jos Hendriksen Source Type: research

Neurofilament as a biomarker - are we there yet?
Eur J Paediatr Neurol. 2023 Jul 5:S1090-3798(23)00104-6. doi: 10.1016/j.ejpn.2023.07.002. Online ahead of print.NO ABSTRACTPMID:37423817 | DOI:10.1016/j.ejpn.2023.07.002 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 9, 2023 Category: Neurology Authors: Cheryl Hemingway Source Type: research

Screening of attention and executive functions in pediatric patients at a tertiary epilepsy center
Eur J Paediatr Neurol. 2023 Jun 25;46:35-41. doi: 10.1016/j.ejpn.2023.06.006. Online ahead of print.ABSTRACTOBJECTIVE: Executive dysfunction is prevalent in children with epilepsy, and associated with poor psychosocial outcome. Sensitive and time effective tools are needed, which capture executive dysfunction across a wide range of impairment. The present study evaluates the applicability of EpiTrack Junior® (EpiTrackJr) as a screening tool at a tertiary epilepsy center, and explore how EpiTrackJr in combination with a subjective measure of everyday attention and executive functions (EFs) may provide clinically important ...
Source: European Journal of Paediatric Neurology - July 7, 2023 Category: Neurology Authors: Lisa E Hauger Morten I Lossius Kari M Aaberg Christoph Helmstaedter Johanne Lossius Annette H Skogan Source Type: research

Screening of attention and executive functions in pediatric patients at a tertiary epilepsy center
Eur J Paediatr Neurol. 2023 Jun 25;46:35-41. doi: 10.1016/j.ejpn.2023.06.006. Online ahead of print.ABSTRACTOBJECTIVE: Executive dysfunction is prevalent in children with epilepsy, and associated with poor psychosocial outcome. Sensitive and time effective tools are needed, which capture executive dysfunction across a wide range of impairment. The present study evaluates the applicability of EpiTrack Junior® (EpiTrackJr) as a screening tool at a tertiary epilepsy center, and explore how EpiTrackJr in combination with a subjective measure of everyday attention and executive functions (EFs) may provide clinically important ...
Source: European Journal of Paediatric Neurology - July 7, 2023 Category: Neurology Authors: Lisa E Hauger Morten I Lossius Kari M Aaberg Christoph Helmstaedter Johanne Lossius Annette H Skogan Source Type: research

Next-generation sequencing and its clinical application in leukoencephalopathies and other pediatric neurological disorders
Eur J Paediatr Neurol. 2023 Jul 3:S1090-3798(23)00102-2. doi: 10.1016/j.ejpn.2023.06.012. Online ahead of print.NO ABSTRACTPMID:37414653 | DOI:10.1016/j.ejpn.2023.06.012 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 6, 2023 Category: Neurology Authors: Jutta G ärtner Simone Schr öder Source Type: research

Real world data on treatment of pediatric onset multiple sclerosis
Eur J Paediatr Neurol. 2023 Jun 30:S1090-3798(23)00101-0. doi: 10.1016/j.ejpn.2023.06.011. Online ahead of print.NO ABSTRACTPMID:37414654 | DOI:10.1016/j.ejpn.2023.06.011 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 6, 2023 Category: Neurology Authors: Rinze Neuteboom Source Type: research

Next-generation sequencing and its clinical application in leukoencephalopathies and other pediatric neurological disorders
Eur J Paediatr Neurol. 2023 Jul 3:S1090-3798(23)00102-2. doi: 10.1016/j.ejpn.2023.06.012. Online ahead of print.NO ABSTRACTPMID:37414653 | DOI:10.1016/j.ejpn.2023.06.012 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 6, 2023 Category: Neurology Authors: Jutta G ärtner Simone Schr öder Source Type: research