Specific CpG sites methylation is associated with hematotoxicity in low-dose benzene-exposed workers
In this study, we recruited 120 low-level benzene-exposed and 101 control male workers from a petrochemical factory in Maoming City, Guangdong Province, China. Urinary S-phenylmercapturic acid (SPMA) in benzene-exposed workers was 3.40-fold higher than that in control workers (P < 0.001). Benzene-induced hematotoxicity was characterized by reduced white blood cells counts and nuclear division index (NDI), along with an increased DNA damage and urinary 8-hydroxy-2'-deoxyguanosine (all P < 0.05). Methylation levels of TRIM36, MGMT and RASSF1a genes in peripheral blood lymphocytes (PBLCs) were quantified by pyrosequenci...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Feier Wang Lizhu Ye Xinhang Jiang Rui Zhang Shen Chen Liping Chen Hongyao Yu Xiaowen Zeng Daochuan Li Xiumei Xing Yongmei Xiao Wen Chen Source Type: research
Variations in thyroid hormone levels in endangered St. Lawrence Estuary belugas: Potential linkage with stress and organohalogen contaminant exposure
The objective of this study was to investigate the impact of concentrations of organohalogen contaminants and stress (cortisol levels) on thyroid hormone variations in adult male and female SLE belugas. Because plasma could not be collected in SLE belugas for ethical reasons, skin biopsy (n = 40) was used as a less-invasive alternative matrix to determine organohalogens (PBDEs and other halogenated flame retardants, polychlorinated biphenyls, and organochlorine pesticides), cortisol, and thyroid hormones (triiodothyronine [T3] and thyroxine [T4]), and their metabolites reverse T3 and 3,5-diiodothyronine [3,5-T2]). Cortisol...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Val érie Jolicoeur Magali Houde Lisa Loseto Robert Michaud Jonathan Verreault Source Type: research
Association of air temperature exposure during pregnancy with risk of preeclampsia in Guangzhou, China
This study aimed to evaluate the correlation between ambient temperature exposure during pregnancy and PE risk, as well as identify the specific time window of temperature exposure that increases PE risk. A population-based cohort study was conducted from January 2012 to April 2022 in Guangzhou, China. Pregnant women were recruited in early pregnancy and followed until delivery. A total of 3,314 PE patients and 114,201 normal pregnancies were included. Ambient temperature exposures at different gestational weeks were recorded for each participant. Logistic regression models were used to evaluate the correlation between amb...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Shanshui Zeng Haojing Liu Bingyu Li Xuanjie Guo Shulei Chen Xuyu Li Jiarui Liang Huaaishi Liang Tingting Shen Yan Long Hongwei Zhou Dongxin Zhang Source Type: research
Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury
Environ Int. 2024 Apr 13;186:108643. doi: 10.1016/j.envint.2024.108643. Online ahead of print.ABSTRACTExposure to bisphenol S (BPS) is known to adversely affect neuronal development. As pivotal components of neuronal polarization, axons and dendrites are indispensable structures within neurons, crucial for the maintenance of nervous system function. Here, we investigated the impact of BPS exposure on axonal and dendritic development both in vivo and in vitro. Our results revealed that exposure to BPS during pregnancy and lactation led to a reduction in the complexity, density, and length of axons and dendrites in the prefr...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Xing Zhang Hongyang Gong Ying Zhao Yangna Wu Jihan Cheng Yuanyuan Song Binquan Wang Yufeng Qin Mingkuan Sun Source Type: research
Nationwide distribution of perfluoroalkyl ether carboxylic acids in Chinese diets: An emerging concern
Environ Int. 2024 Apr 10;186:108648. doi: 10.1016/j.envint.2024.108648. Online ahead of print.ABSTRACTWith the phase-out of perfluorooctanoic acid (PFOA) and its replacement by perfluoroalkyl ether carboxylic acids (PFECAs), there is a potential for increased exposure to various new PFECAs among the general population in China. While there are existing studies on dietary exposure to legacy perfluoroalkyl and polyfluoroalkyl substances (PFASs), research on dietary exposure to PFECAs, especially among the general Chinese populace, remains scarce. In the present study, we investigated the distribution of PFECAs in dietary sou...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Fengfeng Dong Haijun Zhang Nan Sheng Jianglin Hu Jiayin Dai Yitao Pan Source Type: research
Specific CpG sites methylation is associated with hematotoxicity in low-dose benzene-exposed workers
In this study, we recruited 120 low-level benzene-exposed and 101 control male workers from a petrochemical factory in Maoming City, Guangdong Province, China. Urinary S-phenylmercapturic acid (SPMA) in benzene-exposed workers was 3.40-fold higher than that in control workers (P < 0.001). Benzene-induced hematotoxicity was characterized by reduced white blood cells counts and nuclear division index (NDI), along with an increased DNA damage and urinary 8-hydroxy-2'-deoxyguanosine (all P < 0.05). Methylation levels of TRIM36, MGMT and RASSF1a genes in peripheral blood lymphocytes (PBLCs) were quantified by pyrosequenci...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Feier Wang Lizhu Ye Xinhang Jiang Rui Zhang Shen Chen Liping Chen Hongyao Yu Xiaowen Zeng Daochuan Li Xiumei Xing Yongmei Xiao Wen Chen Source Type: research
Variations in thyroid hormone levels in endangered St. Lawrence Estuary belugas: Potential linkage with stress and organohalogen contaminant exposure
The objective of this study was to investigate the impact of concentrations of organohalogen contaminants and stress (cortisol levels) on thyroid hormone variations in adult male and female SLE belugas. Because plasma could not be collected in SLE belugas for ethical reasons, skin biopsy (n = 40) was used as a less-invasive alternative matrix to determine organohalogens (PBDEs and other halogenated flame retardants, polychlorinated biphenyls, and organochlorine pesticides), cortisol, and thyroid hormones (triiodothyronine [T3] and thyroxine [T4]), and their metabolites reverse T3 and 3,5-diiodothyronine [3,5-T2]). Cortisol...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Val érie Jolicoeur Magali Houde Lisa Loseto Robert Michaud Jonathan Verreault Source Type: research
Association of air temperature exposure during pregnancy with risk of preeclampsia in Guangzhou, China
This study aimed to evaluate the correlation between ambient temperature exposure during pregnancy and PE risk, as well as identify the specific time window of temperature exposure that increases PE risk. A population-based cohort study was conducted from January 2012 to April 2022 in Guangzhou, China. Pregnant women were recruited in early pregnancy and followed until delivery. A total of 3,314 PE patients and 114,201 normal pregnancies were included. Ambient temperature exposures at different gestational weeks were recorded for each participant. Logistic regression models were used to evaluate the correlation between amb...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Shanshui Zeng Haojing Liu Bingyu Li Xuanjie Guo Shulei Chen Xuyu Li Jiarui Liang Huaaishi Liang Tingting Shen Yan Long Hongwei Zhou Dongxin Zhang Source Type: research
Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury
Environ Int. 2024 Apr 13;186:108643. doi: 10.1016/j.envint.2024.108643. Online ahead of print.ABSTRACTExposure to bisphenol S (BPS) is known to adversely affect neuronal development. As pivotal components of neuronal polarization, axons and dendrites are indispensable structures within neurons, crucial for the maintenance of nervous system function. Here, we investigated the impact of BPS exposure on axonal and dendritic development both in vivo and in vitro. Our results revealed that exposure to BPS during pregnancy and lactation led to a reduction in the complexity, density, and length of axons and dendrites in the prefr...
Source: Environment International - April 14, 2024 Category: Environmental Health Authors: Xing Zhang Hongyang Gong Ying Zhao Yangna Wu Jihan Cheng Yuanyuan Song Binquan Wang Yufeng Qin Mingkuan Sun Source Type: research
The red listed eagle owl (Bubo bubo) population in Norway is exposed to POP levels exceeding threshold values for adverse health effects
Environ Int. 2024 Apr 10;186:108650. doi: 10.1016/j.envint.2024.108650. Online ahead of print.ABSTRACTThe eagle owl (Bubo bubo) population in Norway is today classified as critically endangered on the red list of endangered species. Because previous studies have detected high concentrations of Persistent Organic Pollutants (POPs) in birds of prey, concerns have been raised whether POPs exposure are a significant factor to the substantial decline of the eagle owl population. The aims of this study were to measure the levels of POPs in eagle owls and to assess whether POPs may represent a potential health risk. POPs were ana...
Source: Environment International - April 13, 2024 Category: Environmental Health Authors: Vidar Torget Aksel Bernhoft Mette Hb M üller Anuschka Polder Hildegunn Viljugrein Knut Madslien Jan Ludvig Lyche Source Type: research
The red listed eagle owl (Bubo bubo) population in Norway is exposed to POP levels exceeding threshold values for adverse health effects
Environ Int. 2024 Apr 10;186:108650. doi: 10.1016/j.envint.2024.108650. Online ahead of print.ABSTRACTThe eagle owl (Bubo bubo) population in Norway is today classified as critically endangered on the red list of endangered species. Because previous studies have detected high concentrations of Persistent Organic Pollutants (POPs) in birds of prey, concerns have been raised whether POPs exposure are a significant factor to the substantial decline of the eagle owl population. The aims of this study were to measure the levels of POPs in eagle owls and to assess whether POPs may represent a potential health risk. POPs were ana...
Source: Environment International - April 13, 2024 Category: Environmental Health Authors: Vidar Torget Aksel Bernhoft Mette Hb M üller Anuschka Polder Hildegunn Viljugrein Knut Madslien Jan Ludvig Lyche Source Type: research
Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson's disease pathology
In conclusion, our study offers novel insights into the multifaceted impacts of PCB-induced perturbations on various cellular contexts relevant to PD. The use of iPSC-derived dopaminergic neurons allowed us to decipher intricate transcriptomic alterations, bridging the gap between in vitro and in vivo findings. This work underscores the potential role of PCB exposure in neurodegenerative diseases like PD, emphasizing the need to consider both systemic and cell specific effects.PMID:38608384 | DOI:10.1016/j.envint.2024.108642 (Source: Environment International)
Source: Environment International - April 12, 2024 Category: Environmental Health Authors: Julian Krauskopf Kristel Eggermont Florian Caiment Catherine Verfaillie Theo M de Kok Source Type: research
Generation of environmentally persistent free radicals on photoaged tire wear particles and their neurotoxic effects on neurotransmission in Caenorhabditis elegans
In this study, the evolution of EPFRs on TWP under different photoaging times and their adverse effects on Caenorhabditis elegans were systematically investigated. The photoaging process primarily resulted in the formation of EPFRs and reactive oxygen species (O2•-, ⋅OH, and 1O2), altering the physicochemical properties of TWP. The exposure of nematodes to 100 μg/L of TWP-50 (TWP with a photoaging time of 50 d) led to a significant decrease in locomotory behaviors (e.g., head thrashes, body bends, and wavelength) and neurotransmitter contents (e.g., dopamine, glutamate, and serotonin). Similarly, the expression of neu...
Source: Environment International - April 12, 2024 Category: Environmental Health Authors: Yulun Gu Yongqi Jiang Xiaoxia Chen Liangzhong Li Haibo Chen Jinyu Chen Chen Wang Jun Yu Chao Chen Hui Li Source Type: research
Forest management positively reshapes the phyllosphere bacterial community and improves community stability
This study provides new evidence of positive forest management effects on the phyllosphere microbiome after extreme drought, from the perspectives of community diversity, structure, network inference, keystone species, and assembly processes. In managed Qinghai spruce forest, the α-diversity of the phyllosphere bacterial communities increased, whereas the β-diversity decreased. In addition, the phyllosphere bacterial community became more stable and resistant, yet less complex, following forest management. Keystone species inferred from a bacterial network also changed under forest management. Furthermore, forest managem...
Source: Environment International - April 11, 2024 Category: Environmental Health Authors: Yunshi Li Ling Jin Minghui Wu Bo Wang Na Qu Huaizhe Zhou Tuo Chen Guangxiu Liu Ming Yue Gaosen Zhang Source Type: research
Ambient air temperature exposure and foetal size and growth in three European birth cohorts
CONCLUSIONS: Cumulative exposure to cold and heat during pregnancy was associated with changes in foetal head circumference throughout gestation, with susceptibility periods for cold during the first pregnancy trimester. No associations were found at birth, suggesting potential recovery. Future research should replicate this study across different climatic regions including varying temperature profiles.PMID:38603813 | DOI:10.1016/j.envint.2024.108619 (Source: Environment International)
Source: Environment International - April 11, 2024 Category: Environmental Health Authors: Esm ée Essers Laura Gran és Scott Delaney Joan Ballester Susana Santos Sami Petricola Tiffany C Yang Ana Fern ández-Somoano Ainhoa Bereziartua Ferran Ballester Adonina Tard ón Martine Vrijheid Aitana Lertxundi Rosemary R C McEachan Hanan El Marroun He Source Type: research
