Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan
CONCLUSION: High ambient temperature and HI may accelerate biological aging.PMID:38507934 | DOI:10.1016/j.envint.2024.108581 (Source: Environment International)
Source: Environment International - March 20, 2024 Category: Environmental Health Authors: Kuan-Chih Chiu Ming-Shun Hsieh Yen-Tsung Huang Chen-Yu Liu Source Type: research
Translational toxicoepigenetic Meta-Analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead exposure in mouse and human offspring
In this study, we aimed to understand the toxicoepigenetic effects on DNA methylation after developmental exposure to two common toxicants, the phthalate di(2-ethylhexyl) phthalate (DEHP) and the metal lead (Pb), using a translational paradigm that selected candidate genes from a mouse study and assessed them in four human birth cohorts. Data from mouse offspring developmentally exposed to DEHP, Pb, or control were used to identify genes with sex-specific sites with differential DNA methylation at postnatal day 21. Associations of human infant DNA methylation in homologous mouse genes with prenatal DEHP or Pb were examined...
Source: Environment International - March 20, 2024 Category: Environmental Health Authors: Rebekah L Petroff Dana C Dolinoy Kai Wang Luke Montrose Vasantha Padmanabhan Karen E Peterson Douglas M Ruden Maureen A Sartor Laurie K Svoboda Martha M T éllez-Rojo Jaclyn M Goodrich Source Type: research
Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke
This study aimed to investigate the effects of chronic exposure to e-cigarette aerosol (ECA) in mice compared to conventional cigarette smoke (CS) exposure. The mice were exposed to air (control), low, medium, or high doses of ECA, or a reference CS dose orally and nasally for eight months. Various cardiovascular and pulmonary assessments have been conducted to determine the biological and prosthetic effects. Histopathological analysis was used to determine structural changes in the heart and lungs. Biological markers associated with fibrosis, inflammation, and oxidative stress were investigated. Cardiac proteomic analysis...
Source: Environment International - March 20, 2024 Category: Environmental Health Authors: Yuxing Dai Wanchun Yang Hongjia Song Xiangjun He Ruoqing Guan Zehong Wu Xingtao Jiang Min Li Peiqing Liu Jianwen Chen Source Type: research
The health and welfare effects of environmental governance: Evidence from China
Environ Int. 2024 Mar 15;185:108579. doi: 10.1016/j.envint.2024.108579. Online ahead of print.ABSTRACTEnvironmental regulations aim to reduce pollution and improve air quality and the health of residents. However, there is a lack of research focusing on the health and welfare effects of low-carbon city pilot policies. In this context, this study takes China's low-carbon city pilot policy as an entry point, focuses on the health effects of public environmental governance, and systematically investigates the effects and mechanisms of low-carbon city development on the health of middle-aged and elderly people by applying the ...
Source: Environment International - March 17, 2024 Category: Environmental Health Authors: Chan Wang Lianggui Liao Xue-Mei Zhang Lu-Tong Lin Bin Chen Source Type: research
Environmental impact of PFAS: Filling data gaps using theoretical quantum chemistry and QSPR modeling
In this study, we employed a combination of physics-based methods and data-driven models to address gaps in PFAS bioaccumulation potential. Using the COnductor-like Screening MOdel for Realistic Solvents (COSMO-RS) method, we predicted n-octanol/water partition coefficients (logKOW), crucial for PFAS bioaccumulation. Our developed Quantitative Structure-Property Relationship (QSPR) model exhibited high accuracy (R2 = 0.95, RMSEC = 0.75) and strong predictive ability (Q2LOO = 0.93, RMSECV = 0.83). Leveraging the extensive NORMAN, we predicted logKOW for over 4,000 compounds, identifying 244 outliers out of 4519. Further cat...
Source: Environment International - March 17, 2024 Category: Environmental Health Authors: Michalina Mudlaff Anita Sosnowska Leonid Gorb Natalia Bulawska Karolina Jagiello Tomasz Puzyn Source Type: research
The health and welfare effects of environmental governance: Evidence from China
Environ Int. 2024 Mar 15;185:108579. doi: 10.1016/j.envint.2024.108579. Online ahead of print.ABSTRACTEnvironmental regulations aim to reduce pollution and improve air quality and the health of residents. However, there is a lack of research focusing on the health and welfare effects of low-carbon city pilot policies. In this context, this study takes China's low-carbon city pilot policy as an entry point, focuses on the health effects of public environmental governance, and systematically investigates the effects and mechanisms of low-carbon city development on the health of middle-aged and elderly people by applying the ...
Source: Environment International - March 17, 2024 Category: Environmental Health Authors: Chan Wang Lianggui Liao Xue-Mei Zhang Lu-Tong Lin Bin Chen Source Type: research
Environmental impact of PFAS: Filling data gaps using theoretical quantum chemistry and QSPR modeling
In this study, we employed a combination of physics-based methods and data-driven models to address gaps in PFAS bioaccumulation potential. Using the COnductor-like Screening MOdel for Realistic Solvents (COSMO-RS) method, we predicted n-octanol/water partition coefficients (logKOW), crucial for PFAS bioaccumulation. Our developed Quantitative Structure-Property Relationship (QSPR) model exhibited high accuracy (R2 = 0.95, RMSEC = 0.75) and strong predictive ability (Q2LOO = 0.93, RMSECV = 0.83). Leveraging the extensive NORMAN, we predicted logKOW for over 4,000 compounds, identifying 244 outliers out of 4519. Further cat...
Source: Environment International - March 17, 2024 Category: Environmental Health Authors: Michalina Mudlaff Anita Sosnowska Leonid Gorb Natalia Bulawska Karolina Jagiello Tomasz Puzyn Source Type: research
The health and welfare effects of environmental governance: Evidence from China
Environ Int. 2024 Mar 15;185:108579. doi: 10.1016/j.envint.2024.108579. Online ahead of print.ABSTRACTEnvironmental regulations aim to reduce pollution and improve air quality and the health of residents. However, there is a lack of research focusing on the health and welfare effects of low-carbon city pilot policies. In this context, this study takes China's low-carbon city pilot policy as an entry point, focuses on the health effects of public environmental governance, and systematically investigates the effects and mechanisms of low-carbon city development on the health of middle-aged and elderly people by applying the ...
Source: Environment International - March 17, 2024 Category: Environmental Health Authors: Chan Wang Lianggui Liao Xue-Mei Zhang Lu-Tong Lin Bin Chen Source Type: research
Environmental impact of PFAS: Filling data gaps using theoretical quantum chemistry and QSPR modeling
In this study, we employed a combination of physics-based methods and data-driven models to address gaps in PFAS bioaccumulation potential. Using the COnductor-like Screening MOdel for Realistic Solvents (COSMO-RS) method, we predicted n-octanol/water partition coefficients (logKOW), crucial for PFAS bioaccumulation. Our developed Quantitative Structure-Property Relationship (QSPR) model exhibited high accuracy (R2 = 0.95, RMSEC = 0.75) and strong predictive ability (Q2LOO = 0.93, RMSECV = 0.83). Leveraging the extensive NORMAN, we predicted logKOW for over 4,000 compounds, identifying 244 outliers out of 4519. Further cat...
Source: Environment International - March 17, 2024 Category: Environmental Health Authors: Michalina Mudlaff Anita Sosnowska Leonid Gorb Natalia Bulawska Karolina Jagiello Tomasz Puzyn Source Type: research
Effects of radiofrequency electromagnetic field (RF-EMF) exposure on male fertility: A systematic review of experimental studies on non-human mammals and human sperm in vitro
DISCUSSION: Many of the studies examined suffered of severe limitations that led to the attribution of uncertainty to the results of the meta-analyses and did not allow to draw firm conclusions on most of the endpoints. Nevertheless, the associations between RF-EMF exposure and decrease of pregnancy rate and sperm count, to which moderate and low certainty were attributed, are not negligible, also in view of the indications that in Western countries human male fertility potential seems to be progressively declining. It was beyond the scope of our systematic review to determine the shape of the dose-response relationship or...
Source: Environment International - March 16, 2024 Category: Environmental Health Authors: Eugenia Cordelli Lucia Ardoino Barbara Benassi Claudia Consales Patrizia Eleuteri Carmela Marino Maurizio Sciortino Paola Villani Martin H Brinkworth Guangdi Chen James P McNamee Andrew W Wood Lea Belackova Jos Verbeek Francesca Pacchierotti Source Type: research
Improving consistency in estimating future health burdens from environmental risk factors: Case study for ambient air pollution
Environ Int. 2024 Mar 13;185:108560. doi: 10.1016/j.envint.2024.108560. Online ahead of print.ABSTRACTFuture changes in exposure to risk factors should impact mortality rates and population. However, studies commonly use mortality rates and population projections developed exogenously to the health impact assessment model used to quantify future health burdens attributable to environmental risks that are therefore invariant to projected exposure levels. This impacts the robustness of many future health burden estimates for environmental risk factors. This work describes an alternative methodology that more consistently rep...
Source: Environment International - March 16, 2024 Category: Environmental Health Authors: Christopher S Malley Susan C Anenberg Drew T Shindell Source Type: research
The ABC of mobility
Environ Int. 2024 Mar 2;185:108541. doi: 10.1016/j.envint.2024.108541. Online ahead of print.ABSTRACTThe use of cars in cities has many negative impacts, including pollution, noise and the use of space. Yet, detecting factors that reduce the use of cars is a serious challenge, particularly across different regions. Here, we model the use of various modes of transport in a city by aggregating Active mobility (A), Public Transport (B) and Cars (C), expressing the modal share of a city by its ABC triplet. Data for nearly 800 cities across 61 countries is used to model car use and its relationship with city size and income. Ou...
Source: Environment International - March 16, 2024 Category: Environmental Health Authors: Rafael Prieto-Curiel Juan P Ospina Source Type: research
Effects of radiofrequency electromagnetic field (RF-EMF) exposure on male fertility: A systematic review of experimental studies on non-human mammals and human sperm in vitro
DISCUSSION: Many of the studies examined suffered of severe limitations that led to the attribution of uncertainty to the results of the meta-analyses and did not allow to draw firm conclusions on most of the endpoints. Nevertheless, the associations between RF-EMF exposure and decrease of pregnancy rate and sperm count, to which moderate and low certainty were attributed, are not negligible, also in view of the indications that in Western countries human male fertility potential seems to be progressively declining. It was beyond the scope of our systematic review to determine the shape of the dose-response relationship or...
Source: Environment International - March 16, 2024 Category: Environmental Health Authors: Eugenia Cordelli Lucia Ardoino Barbara Benassi Claudia Consales Patrizia Eleuteri Carmela Marino Maurizio Sciortino Paola Villani Martin H Brinkworth Guangdi Chen James P McNamee Andrew W Wood Lea Belackova Jos Verbeek Francesca Pacchierotti Source Type: research
Improving consistency in estimating future health burdens from environmental risk factors: Case study for ambient air pollution
Environ Int. 2024 Mar 13;185:108560. doi: 10.1016/j.envint.2024.108560. Online ahead of print.ABSTRACTFuture changes in exposure to risk factors should impact mortality rates and population. However, studies commonly use mortality rates and population projections developed exogenously to the health impact assessment model used to quantify future health burdens attributable to environmental risks that are therefore invariant to projected exposure levels. This impacts the robustness of many future health burden estimates for environmental risk factors. This work describes an alternative methodology that more consistently rep...
Source: Environment International - March 16, 2024 Category: Environmental Health Authors: Christopher S Malley Susan C Anenberg Drew T Shindell Source Type: research
The ABC of mobility
Environ Int. 2024 Mar 2;185:108541. doi: 10.1016/j.envint.2024.108541. Online ahead of print.ABSTRACTThe use of cars in cities has many negative impacts, including pollution, noise and the use of space. Yet, detecting factors that reduce the use of cars is a serious challenge, particularly across different regions. Here, we model the use of various modes of transport in a city by aggregating Active mobility (A), Public Transport (B) and Cars (C), expressing the modal share of a city by its ABC triplet. Data for nearly 800 cities across 61 countries is used to model car use and its relationship with city size and income. Ou...
Source: Environment International - March 16, 2024 Category: Environmental Health Authors: Rafael Prieto-Curiel Juan P Ospina Source Type: research
