Effects of common artificial sweeteners at environmentally relevant concentrations on soil springtails and their gut microbiota
Environ Int. 2024 Feb 12;185:108496. doi: 10.1016/j.envint.2024.108496. Online ahead of print.ABSTRACTArtificial sweeteners (AS) are extensively utilized as sugar substitutes and have been recognized as emerging environmental contaminants. While the effect of AS on aquatic organisms has garnered recent attention, their effects on soil invertebrates and gut microbial communities remain unclear. To address this knowledge gap, we exposed springtails (Folsomia candida) to both single and combined treatments of four typical AS (sucralose [SUC], saccharin [SAC], cyclamate [CYC], and acesulfame [ACE]) at environmentally relevant ...
Source: Environment International - February 15, 2024 Category: Environmental Health Authors: Xiang-Long Lin Fei Guo Matthias C Rillig Chun Chen Gui-Lan Duan Yong-Guan Zhu Source Type: research

Gestational α-ketoglutarate supplementation ameliorates arsenic-induced hepatic lipid deposition via epigenetic reprogramming of β-oxidation process in female offspring
In this study, we initially found that gestational exposure to iAsⅢ at an environmentally relevant concentration disturbs lipid metabolism and reduces levels of alpha-ketoglutaric acid (α-KG), an important mitochondrial metabolite during the citric acid cycle, in fetal livers. Further, gestational supplementation of α-KG alleviated hepatic lipid deposition caused by early-life exposure to iAsⅢ. This beneficial effect was particularly pronounced in female offspring. α-KG partially restored the β-oxidation process in hepatic tissues by hydroxymethylation modifications of carnitine palmitoyltransferase 1a (Cpt1a) gene...
Source: Environment International - February 15, 2024 Category: Environmental Health Authors: Qing-Hua Qian Ya-Ping Song Yu Zhang Hao Xue Wei-Wei Zhang Yapeng Han Y án Wāng De-Xiang Xu Source Type: research

Association between electrocardiographic abnormalities and flood exposure among middle-aged and elderly people: A national longitudinal study in China
CONCLUSION: Flood exposure was associated with an increased long-term risk for an ECG abnormality. The need for effective measures to mitigate vulnerability to flood is not negligible in China.PMID:38359548 | DOI:10.1016/j.envint.2024.108484 (Source: Environment International)
Source: Environment International - February 15, 2024 Category: Environmental Health Authors: Pengfei Li Jingyi Wu Jiwei Li Mingkun Tong Yuanli Liu Tao Xue Tianjia Guan Source Type: research

Effects of common artificial sweeteners at environmentally relevant concentrations on soil springtails and their gut microbiota
Environ Int. 2024 Feb 12;185:108496. doi: 10.1016/j.envint.2024.108496. Online ahead of print.ABSTRACTArtificial sweeteners (AS) are extensively utilized as sugar substitutes and have been recognized as emerging environmental contaminants. While the effect of AS on aquatic organisms has garnered recent attention, their effects on soil invertebrates and gut microbial communities remain unclear. To address this knowledge gap, we exposed springtails (Folsomia candida) to both single and combined treatments of four typical AS (sucralose [SUC], saccharin [SAC], cyclamate [CYC], and acesulfame [ACE]) at environmentally relevant ...
Source: Environment International - February 15, 2024 Category: Environmental Health Authors: Xiang-Long Lin Fei Guo Matthias C Rillig Chun Chen Gui-Lan Duan Yong-Guan Zhu Source Type: research

Gestational α-ketoglutarate supplementation ameliorates arsenic-induced hepatic lipid deposition via epigenetic reprogramming of β-oxidation process in female offspring
In this study, we initially found that gestational exposure to iAsⅢ at an environmentally relevant concentration disturbs lipid metabolism and reduces levels of alpha-ketoglutaric acid (α-KG), an important mitochondrial metabolite during the citric acid cycle, in fetal livers. Further, gestational supplementation of α-KG alleviated hepatic lipid deposition caused by early-life exposure to iAsⅢ. This beneficial effect was particularly pronounced in female offspring. α-KG partially restored the β-oxidation process in hepatic tissues by hydroxymethylation modifications of carnitine palmitoyltransferase 1a (Cpt1a) gene...
Source: Environment International - February 15, 2024 Category: Environmental Health Authors: Qing-Hua Qian Ya-Ping Song Yu Zhang Hao Xue Wei-Wei Zhang Yapeng Han Y án Wāng De-Xiang Xu Source Type: research

Adherence to the EAT-Lancet diet in relation to mortality and exposure to food contaminants in population-based cohorts of Swedish men and women
CONCLUSION: High adherence to the EAT-Lancet diet is associated with a reduction in risk of all-cause and cardiovascular-mortality, but also increased dietary exposure to food contaminants.PMID:38354461 | DOI:10.1016/j.envint.2024.108495 (Source: Environment International)
Source: Environment International - February 14, 2024 Category: Environmental Health Authors: Stephanie Pitt Joanna Ka łuża Anneli Widenfalk Agneta Åkesson Alicja Wolk Source Type: research

Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment
Environ Int. 2024 Feb 8;184:108474. doi: 10.1016/j.envint.2024.108474. Online ahead of print.ABSTRACTHuman health risk assessment is historically built upon animal testing, often following Organisation for Economic Co-operation and Development (OECD) test guidelines and exposure assessments. Using combinations of human relevant in vitro models, chemical analysis and computational (in silico) approaches bring advantages compared to animal studies. These include a greater focus on the human species and on molecular mechanisms and kinetics, identification of Adverse Outcome Pathways and downstream Key Events as well as the po...
Source: Environment International - February 13, 2024 Category: Environmental Health Authors: Elena Reale Maryam Zare Jeddi Alicia Paini Alison Connolly Radu Duca Francesco Cubadda Emilio Benfenati Jos Bessems Karen S Galea Hubert Dirven Tiina Santonen Holger M Koch Kate Jones Craig Sams Susana Viegas Machera Kyriaki Luca Campisi Arthur David Jean Source Type: research

HIF-1 α/m < sup > 6 < /sup > A/NF- κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity
Environ Int. 2024 Feb 10;184:108493. doi: 10.1016/j.envint.2024.108493. Online ahead of print.ABSTRACTDefective erythropoiesis is one of the causes of anemia and leukemia. However, the mechanisms underlying defective erythropoiesis under a low-dose environment of benzene are poorly understood. In the present study, multiple omics (transcriptomics and metabolomics) and methods from epidemiology to experimental biology (e.g., benzene-induced (WT and HIF-1α + ) mouse, hiPSC-derived HSPCs) were used. Here, we showed that erythropoiesis is more easily impacted than other blood cells, and the process is reversible, which involv...
Source: Environment International - February 13, 2024 Category: Environmental Health Authors: Xiaowei Cong Xiaoqin Li Kai Xu Lihong Yin Geyu Liang Rongli Sun Yuepu Pu Juan Zhang Source Type: research

Internal exposure potential of water-soluble organic molecules in urban PM < sub > 2.5 < /sub > evaluated by non-covalent adductome of human serum albumin
In this study, the non-covalent HSA-WSOM adductome was developed as a dosimeter to evaluate the internal exposure potential of WSOMs in urban PM2.5. The WSOM composition was acquired from non-target high-resolution mass spectrometry analysis coupled with multiple ionizations. The binding level of HSA-WSOM non-covalent adducts was obtained from surface plasma resonance. Machine learning combined WSOM composition and the binding level of HSA-WSOM non-covalent adducts to screen bindable (also internalizable) WSOMs. The concentration of WSOM ranged from 4 to 13 μg/m3 during our observation period. Of the 17,513 mass spectral ...
Source: Environment International - February 13, 2024 Category: Environmental Health Authors: Yaling Zeng Antai Zhang Xin Yang Chunbo Xing Jinghao Zhai Yixiang Wang Baohua Cai Shao Shi Yujie Zhang Zhenxing Shen Tzung-May Fu Lei Zhu Huizhong Shen Jianhuai Ye Chen Wang Source Type: research

Association between dietary pesticide exposure profiles and body weight change in French adults: Results from the NutriNet-Sant é cohort
CONCLUSIONS: This study suggests a role of pesticide exposure, inferred from dietary patterns, on BW change, with sexually dimorphic actions, including a potential role of a lower exposure to synthetic pesticides on BW change in women. In men, exposure to a specific pesticide mixture was associated with higher BW loss. The underlying mechanisms need further elucidation.PMID:38350259 | DOI:10.1016/j.envint.2024.108485 (Source: Environment International)
Source: Environment International - February 13, 2024 Category: Environmental Health Authors: Justine Berlivet Laurence Payrastre Pauline Rebouillat Anne Fougerat Mathilde Touvier Serge Hercberg Denis Lairon Philippe Pointereau Herv é Guillou Rodolphe Vidal Julia Baudry Emmanuelle Kesse-Guyot Source Type: research

Comprehensive characterization and prioritization of halogenated organic compounds in fish and their implications for exposure
This study performed nontarget and comprehensive analyses of HOCs in fish from an e-waste recycling zone by gas chromatography-high-resolution mass spectrometry, and further prioritized their human exposure risks. A total of 1652 formulas of HOCs were found in the fish, of which 1222, 117, and 313 were organochlorines, organobromines, and organochlorine-bromines, respectively. The total concentrations of HOCs were 15.4-18.7 μg/g (wet weight), and organobromines were the predominant (14.1-16.8 μg/g). Of the HOCs, 41 % were elucidated with tentative structures and divided into 13 groups. The estimated total daily exposures...
Source: Environment International - February 12, 2024 Category: Environmental Health Authors: Caiming Tang Ling Liu Ruifen Zheng Yizhe Zhu Caixing Tang Yan-Hong Zeng Xiao-Jun Luo Bi-Xian Mai Source Type: research

1,2-Dichloroethane induces testicular pyroptosis by activating piR-mmu-1019957/IRF7 pathway and the protective effects of melatonin
Environ Int. 2024 Feb 9;184:108480. doi: 10.1016/j.envint.2024.108480. Online ahead of print.ABSTRACT1,2-Dichloroethane (1,2-DCE) is a prevalent environmental contaminant, and our study revealed its induction of testicular toxicity in mice upon subacute exposure. Melatonin, a prominent secretory product of the pineal gland, has been shown to offer protection against pyroptosis in male reproductive toxicity. However, the exact mechanism underlying 1,2-DCE-induced testicular toxicity and the comprehensive extent of melatonin's protective effects in this regard remain largely unexplored. Therefore, we sequenced testis piRNAs ...
Source: Environment International - February 11, 2024 Category: Environmental Health Authors: Bingli Zhang Yizhou Zhong Jiaxin Du Rongyi Ye Bingchi Fan Yanhong Deng Ruobing Bai Yu Feng Xiaohong Yang Yuji Huang Boxuan Liang Jiewei Zheng Weifeng Rong Xingfen Yang Zhenlie Huang Source Type: research

Impact of heatwaves on all-cause mortality in India: A comprehensive multi-city study
CONCLUSIONS: We found strong evidence of heatwave impacts on daily mortality. Longer and more intense heatwaves were linked to an increased mortality risk, however, resulted in a lower burden of heatwave-related deaths. Both definitions and the burden associated with each heatwave definition should be incorporated into planning and decision-making processes for policymakers.PMID:38340402 | DOI:10.1016/j.envint.2024.108461 (Source: Environment International)
Source: Environment International - February 10, 2024 Category: Environmental Health Authors: Jeroen de Bont Amruta Nori-Sarma Massimo Stafoggia Tirthankar Banerjee Vijendra Ingole Suganthi Jaganathan Siddhartha Mandal Ajit Rajiva Bhargav Krishna Itai Kloog Kevin Lane Rajesh K Mall Abhiyant Tiwari Yaguang Wei Gregory A Wellenius Dorairaj Prabhakar Source Type: research

Ecological interruption on food web dynamics by eutrophic water discharge from the world's longest dike at Saemangeum, Yellow Sea
Environ Int. 2024 Feb 2;184:108468. doi: 10.1016/j.envint.2024.108468. Online ahead of print.ABSTRACTThe man-made sea dike has disrupted the natural link between riverine and marine ecosystems and caused eutrophication within the aquatic ecosystem. The eutrophic water discharge has also raised concerns. As a representative tidal flat with the longest dike in the world, Saemangeum has experienced the problem of eutrophication. To elucidate the discharge water effects on the benthic food web dynamics, a four-year round sampling was conducted in/outside of the Saemangeum sea dike. Stable isotope analysis was applied to bentho...
Source: Environment International - February 10, 2024 Category: Environmental Health Authors: In Ok Lee Hosang Kim Inha Kwon Bong-Oh Kwon Jae-Sung Kim Junghyun Lee Jungho Nam Junsung Noh Jong Seong Khim Source Type: research

Constraining East Asia ammonia emissions through satellite observations and iterative Finite Difference Mass Balance (iFDMB) and investigating its impact on inorganic fine particulate matter
This study highlights the challenge of controlling and managing inorganic PM2.5 and indicates that reducing the emissions of air pollutants do not necessarily lead to a reduction in their concentrations.PMID:38340404 | DOI:10.1016/j.envint.2024.108473 (Source: Environment International)
Source: Environment International - February 10, 2024 Category: Environmental Health Authors: Mahmoudreza Momeni Yunsoo Choi Arash Kashfi Yeganeh Arman Pouyaei Jia Jung Jincheol Park Mark W Shephard Enrico Dammers Karen E Cady-Pereira Source Type: research