Interaction of tetracycline and copper co-intake in inducing antibiotic resistance genes and potential pathogens in mouse gut
Environ Int. 2024 Mar 21;186:108594. doi: 10.1016/j.envint.2024.108594. Online ahead of print.ABSTRACTThe widespread use of copper and tetracycline as growth promoters in the breeding industry poses a potential threat to environmental health. Nevertheless, to the best of our knowledge, the potential adverse effects of copper and tetracycline on the gut microbiota remain unknown. Herein, mice were fed different concentrations of copper and/or tetracycline for 6 weeks to simulate real life-like exposure in the breeding industry. Following the exposure, antibiotic resistance genes (ARGs), potential pathogens, and other pathog...
Source: Environment International - March 25, 2024 Category: Environmental Health Authors: Ying-Xin Xue Li-Jie Huang Hong-Yu Wang Jing-Jing Peng Ming-Kang Jin Shi-Lin Hu Hong-Bo Li Xi-Mei Xue Yong-Guan Zhu Source Type: research
Bioactivity assessment of organophosphate flame retardants via a dose-dependent yeast functional genomics approach
Environ Int. 2024 Mar 23;186:108596. doi: 10.1016/j.envint.2024.108596. Online ahead of print.ABSTRACTOrganophosphate flame retardants (OPFRs) have been widely detected in multiple environment media and have many adverse effects with complex toxicity mechanisms. However, the early molecular responses to OPFRs have not been fully elucidated, thereby making it difficult to assess their risks accurately. In this work, we systematically explored the point of departure (POD) of biological pathways at genome-wide level perturbed by 14 OPFRs with three substituents (alkyl, halogen, and aryl) using a dose-dependent functional geno...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Miao Guan Xiaoyang Wang Xinyuan Xu Tianqi Ling Jing Wu Jinjun Qian Fei Ma Xiaowei Zhang Source Type: research
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity
Environ Int. 2024 Mar 20;186:108569. doi: 10.1016/j.envint.2024.108569. Online ahead of print.ABSTRACTEnvironmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs are linked with obesity and insulin resistance partly through a dysbiotic gut microbiota and changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- and polyfluoroalkyl substances (PFAS) and additional twenty-seven ETs were measured by mass spectrometry in 264 Danes (121 men and 143 women, aged 56.6 ± 7.3 years, BMI 29.7 ± 6.0 kg/m2) using a combination of targeted and suspect screening...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Partho Sen Yong Fan Jennifer J Schlezinger Stanislav D Ehrlich Thomas F Webster Tuulia Hy ötyläinen Oluf Pedersen Matej Ore šič Source Type: research
Source emission contributions to particulate matter and ozone, and their health impacts in Southeast Asia
Environ Int. 2024 Mar 18;186:108578. doi: 10.1016/j.envint.2024.108578. Online ahead of print.ABSTRACTSoutheast Asia has been experiencing severe air pollution due to its substantial local emissions and transboundary air pollution (TAP), causing significant health impacts. While literature focused on air pollution episodes in Southeast Asia, we have yet to fully understand the contributions of local emission sectors and TAP to air quality in the region annually. Herein we employed air quality modeling with the species tagging method to first assess the contributions of source sectors and locations to fine particulate matte...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Yefu Gu Tingting Fang Steve Hung Lam Yim Source Type: research
Bioactivity assessment of organophosphate flame retardants via a dose-dependent yeast functional genomics approach
Environ Int. 2024 Mar 23;186:108596. doi: 10.1016/j.envint.2024.108596. Online ahead of print.ABSTRACTOrganophosphate flame retardants (OPFRs) have been widely detected in multiple environment media and have many adverse effects with complex toxicity mechanisms. However, the early molecular responses to OPFRs have not been fully elucidated, thereby making it difficult to assess their risks accurately. In this work, we systematically explored the point of departure (POD) of biological pathways at genome-wide level perturbed by 14 OPFRs with three substituents (alkyl, halogen, and aryl) using a dose-dependent functional geno...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Miao Guan Xiaoyang Wang Xinyuan Xu Tianqi Ling Jing Wu Jinjun Qian Fei Ma Xiaowei Zhang Source Type: research
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity
Environ Int. 2024 Mar 20;186:108569. doi: 10.1016/j.envint.2024.108569. Online ahead of print.ABSTRACTEnvironmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs are linked with obesity and insulin resistance partly through a dysbiotic gut microbiota and changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- and polyfluoroalkyl substances (PFAS) and additional twenty-seven ETs were measured by mass spectrometry in 264 Danes (121 men and 143 women, aged 56.6 ± 7.3 years, BMI 29.7 ± 6.0 kg/m2) using a combination of targeted and suspect screening...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Partho Sen Yong Fan Jennifer J Schlezinger Stanislav D Ehrlich Thomas F Webster Tuulia Hy ötyläinen Oluf Pedersen Matej Ore šič Source Type: research
Source emission contributions to particulate matter and ozone, and their health impacts in Southeast Asia
Environ Int. 2024 Mar 18;186:108578. doi: 10.1016/j.envint.2024.108578. Online ahead of print.ABSTRACTSoutheast Asia has been experiencing severe air pollution due to its substantial local emissions and transboundary air pollution (TAP), causing significant health impacts. While literature focused on air pollution episodes in Southeast Asia, we have yet to fully understand the contributions of local emission sectors and TAP to air quality in the region annually. Herein we employed air quality modeling with the species tagging method to first assess the contributions of source sectors and locations to fine particulate matte...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Yefu Gu Tingting Fang Steve Hung Lam Yim Source Type: research
Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
Environ Int. 2024 Mar 16;186:108577. doi: 10.1016/j.envint.2024.108577. Online ahead of print.ABSTRACTMale fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse male reproductive health. The mechanisms of these associations and their implications on offspring health remain unknown. The aims of the current study were to assess the effect of PFAS mixtures on the sperm methylome and transcriptional changes in offspring metabolic tissues (i.e., liver a...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: DruAnne L Maxwell Oladele A Oluwayiose Emily Houle Katherine Roth Karolina Nowak Savni Sawant Amanda L Paskavitz Wanqing Liu Katherine Gurdziel Michael C Petriello J Richard Pilsner Source Type: research
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment
Environ Int. 2024 Mar 17;186:108585. doi: 10.1016/j.envint.2024.108585. Online ahead of print.ABSTRACTThe chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: Žiga Tkalec Jean-Philippe Antignac Nicole Bandow Frederic M B éen Lidia Belova Jos Bessems Bruno Le Bizec Werner Brack German Cano-Sancho Jade Chaker Adrian Covaci Nicolas Creusot Arthur David Laurent Debrauwer Gaud Dervilly Radu Corneliu Duca Val érie Source Type: research
Synergistic control potential of flue gas pollutants under Ultra-Low emission standards in waste incineration plants
Environ Int. 2024 Mar 20;186:108590. doi: 10.1016/j.envint.2024.108590. Online ahead of print.ABSTRACTAs the dominant waste disposal process, incineration is regarded as the main incentive for the "not-in-my-backyard" syndrome, and faces an inescapable pressures of ultra-low emissions (ULE). Establishing precise response relationships between emission factors (EFs) and full-process influencing factors can provide guidance for the synergistic mitigation of flue gas pollutants (FGPs). In this work, the multi-dimensional EFs of FGPs were identified by initially integrating FGPs concentration monitoring data of existing 1,226 ...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: Jicui Cui Jiyang Li Haoyu Zhang Ruina Zhang Wenchao Ma Ying Zhu Wenxiang Yuan Michael Palocz-Andresen Youcai Zhao Ziyang Lou Source Type: research
Pregnancy exposure to PM < sub > 2.5 < /sub > from wildland fire smoke and preterm birth in California
CONCLUSIONS: Preterm birth is sensitive to wildland fire PM2.5; therefore, we must reduce exposure during pregnancy.PMID:38521046 | DOI:10.1016/j.envint.2024.108583 (Source: Environment International)
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: Sally Picciotto ShihMing Huang Frederick Lurmann Nathan Pavlovic Shih Ying Chang Anondo Mukherjee Dana E Goin Rachel Sklar Elizabeth Noth Rachel Morello-Frosch Amy M Padula Source Type: research
Dust particulate matter increases pulmonary embolism onset: A nationwide time-stratified case-crossover study in China
CONCLUSIONS: The findings from this study suggest that short-term exposure to dust PM, particularly dust PM2.5, may trigger PE onset, posing a significant health threat. Implementing measures to mitigate dust PM emissions and protect patients with PE from dust PM exposure is imperative.PMID:38521047 | DOI:10.1016/j.envint.2024.108586 (Source: Environment International)
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: Can Zhang Dan Zhao Feng Liu Jing Yang Jie Ban Peng Du Kailai Lu Runmei Ma Yuanyuan Liu Qinghua Sun Siyu Chen Tiantian Li Source Type: research
Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
Environ Int. 2024 Mar 16;186:108577. doi: 10.1016/j.envint.2024.108577. Online ahead of print.ABSTRACTMale fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse male reproductive health. The mechanisms of these associations and their implications on offspring health remain unknown. The aims of the current study were to assess the effect of PFAS mixtures on the sperm methylome and transcriptional changes in offspring metabolic tissues (i.e., liver a...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: DruAnne L Maxwell Oladele A Oluwayiose Emily Houle Katherine Roth Karolina Nowak Savni Sawant Amanda L Paskavitz Wanqing Liu Katherine Gurdziel Michael C Petriello J Richard Pilsner Source Type: research
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment
Environ Int. 2024 Mar 17;186:108585. doi: 10.1016/j.envint.2024.108585. Online ahead of print.ABSTRACTThe chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: Žiga Tkalec Jean-Philippe Antignac Nicole Bandow Frederic M B éen Lidia Belova Jos Bessems Bruno Le Bizec Werner Brack German Cano-Sancho Jade Chaker Adrian Covaci Nicolas Creusot Arthur David Laurent Debrauwer Gaud Dervilly Radu Corneliu Duca Val érie Source Type: research
Synergistic control potential of flue gas pollutants under Ultra-Low emission standards in waste incineration plants
Environ Int. 2024 Mar 20;186:108590. doi: 10.1016/j.envint.2024.108590. Online ahead of print.ABSTRACTAs the dominant waste disposal process, incineration is regarded as the main incentive for the "not-in-my-backyard" syndrome, and faces an inescapable pressures of ultra-low emissions (ULE). Establishing precise response relationships between emission factors (EFs) and full-process influencing factors can provide guidance for the synergistic mitigation of flue gas pollutants (FGPs). In this work, the multi-dimensional EFs of FGPs were identified by initially integrating FGPs concentration monitoring data of existing 1,226 ...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: Jicui Cui Jiyang Li Haoyu Zhang Ruina Zhang Wenchao Ma Ying Zhu Wenxiang Yuan Michael Palocz-Andresen Youcai Zhao Ziyang Lou Source Type: research
