Usefulness of a new immunochromatographic assay using fluorescent silica nanoparticles for serodiagnosis of Thai patients with amebiasis
Drug Discov Ther. 2024 Feb 15. doi: 10.5582/ddt.2023.01102. Online ahead of print.ABSTRACTA fluorescence immunochromatography (FIC) kit was developed recently using fluorescent silica nanoparticles coated with a recombinant C-terminal fragment of the surface lectin intermediate subunit (C-Igl) of Entamoeba histolytica to establish rapid serodiagnosis of amebiasis. We further evaluated the system using serum samples from 52 Thai patients with amebiasis. Of the patients, 50 (96%) tested positive using FIC. The samples were also tested using enzyme-linked immunosorbent assay (ELISA) with C-Igl as the antigen. Two samples were...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Azumi Kakino Urassaya Pattanawong Napaporn Kuamsab Tatsuya Imai Chaturong Putaporntip Satomi Asai Xunjia Cheng Somchai Jongwutiwes Hiroshi Tachibana Source Type: research
Quantitative parameters of contrast-enhanced ultrasound effectively promote the prediction of cervical lymph node metastasis in papillary thyroid carcinoma
In conclusion, PI has significance in predicting CLNM for PTC > 10 mm; however, it is not helpful for PTC ≤ 10 mm.PMID:38355122 | DOI:10.5582/ddt.2023.01095 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Biao Su Lisha Li Yingchun Liu Hui Liu Jia Zhan Qiliang Chai Liang Fang Ling Wang Lin Chen Source Type: research
Association between the experience of exertional heat illness (EHI) and living conditions of collegiate student athletes
This study aimed to clarify the association between the cognizance of experiencing EHI and living conditions and specific EHI symptoms among collegiate athletes. This study was conducted in October 2022 by administering a questionnaire to 237 male collegiate athletes. Of the 215 (90.7%) respondents, 197 (91.6%) provided valid responses; among them, 88 (44.7%) responded they had experienced EHI, while 109 (55.3%) had not. A history of medical examinations due to EHI, having experienced headaches during summer activities, and having read the EHI manual were factors indicating cognizance of EHI. The number of times meals cont...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Yoko Iio Mamoru Tanaka Hana Kozai Yuka Aoyama Yukihiro Mori Manato Seguchi Morihiro Ito Source Type: research
Usefulness of a new immunochromatographic assay using fluorescent silica nanoparticles for serodiagnosis of Thai patients with amebiasis
Drug Discov Ther. 2024 Feb 15. doi: 10.5582/ddt.2023.01102. Online ahead of print.ABSTRACTA fluorescence immunochromatography (FIC) kit was developed recently using fluorescent silica nanoparticles coated with a recombinant C-terminal fragment of the surface lectin intermediate subunit (C-Igl) of Entamoeba histolytica to establish rapid serodiagnosis of amebiasis. We further evaluated the system using serum samples from 52 Thai patients with amebiasis. Of the patients, 50 (96%) tested positive using FIC. The samples were also tested using enzyme-linked immunosorbent assay (ELISA) with C-Igl as the antigen. Two samples were...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Azumi Kakino Urassaya Pattanawong Napaporn Kuamsab Tatsuya Imai Chaturong Putaporntip Satomi Asai Xunjia Cheng Somchai Jongwutiwes Hiroshi Tachibana Source Type: research
Quantitative parameters of contrast-enhanced ultrasound effectively promote the prediction of cervical lymph node metastasis in papillary thyroid carcinoma
In conclusion, PI has significance in predicting CLNM for PTC > 10 mm; however, it is not helpful for PTC ≤ 10 mm.PMID:38355122 | DOI:10.5582/ddt.2023.01095 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Biao Su Lisha Li Yingchun Liu Hui Liu Jia Zhan Qiliang Chai Liang Fang Ling Wang Lin Chen Source Type: research
Association between the experience of exertional heat illness (EHI) and living conditions of collegiate student athletes
This study aimed to clarify the association between the cognizance of experiencing EHI and living conditions and specific EHI symptoms among collegiate athletes. This study was conducted in October 2022 by administering a questionnaire to 237 male collegiate athletes. Of the 215 (90.7%) respondents, 197 (91.6%) provided valid responses; among them, 88 (44.7%) responded they had experienced EHI, while 109 (55.3%) had not. A history of medical examinations due to EHI, having experienced headaches during summer activities, and having read the EHI manual were factors indicating cognizance of EHI. The number of times meals cont...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Yoko Iio Mamoru Tanaka Hana Kozai Yuka Aoyama Yukihiro Mori Manato Seguchi Morihiro Ito Source Type: research
Usefulness of a new immunochromatographic assay using fluorescent silica nanoparticles for serodiagnosis of Thai patients with amebiasis
Drug Discov Ther. 2024 Feb 15. doi: 10.5582/ddt.2023.01102. Online ahead of print.ABSTRACTA fluorescence immunochromatography (FIC) kit was developed recently using fluorescent silica nanoparticles coated with a recombinant C-terminal fragment of the surface lectin intermediate subunit (C-Igl) of Entamoeba histolytica to establish rapid serodiagnosis of amebiasis. We further evaluated the system using serum samples from 52 Thai patients with amebiasis. Of the patients, 50 (96%) tested positive using FIC. The samples were also tested using enzyme-linked immunosorbent assay (ELISA) with C-Igl as the antigen. Two samples were...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Azumi Kakino Urassaya Pattanawong Napaporn Kuamsab Tatsuya Imai Chaturong Putaporntip Satomi Asai Xunjia Cheng Somchai Jongwutiwes Hiroshi Tachibana Source Type: research
Quantitative parameters of contrast-enhanced ultrasound effectively promote the prediction of cervical lymph node metastasis in papillary thyroid carcinoma
In conclusion, PI has significance in predicting CLNM for PTC > 10 mm; however, it is not helpful for PTC ≤ 10 mm.PMID:38355122 | DOI:10.5582/ddt.2023.01095 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Biao Su Lisha Li Yingchun Liu Hui Liu Jia Zhan Qiliang Chai Liang Fang Ling Wang Lin Chen Source Type: research
Association between the experience of exertional heat illness (EHI) and living conditions of collegiate student athletes
This study aimed to clarify the association between the cognizance of experiencing EHI and living conditions and specific EHI symptoms among collegiate athletes. This study was conducted in October 2022 by administering a questionnaire to 237 male collegiate athletes. Of the 215 (90.7%) respondents, 197 (91.6%) provided valid responses; among them, 88 (44.7%) responded they had experienced EHI, while 109 (55.3%) had not. A history of medical examinations due to EHI, having experienced headaches during summer activities, and having read the EHI manual were factors indicating cognizance of EHI. The number of times meals cont...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Yoko Iio Mamoru Tanaka Hana Kozai Yuka Aoyama Yukihiro Mori Manato Seguchi Morihiro Ito Source Type: research
Development of amyloid beta-directed antibodies against Alzheimer's disease: Twists and turns
Drug Discov Ther. 2023;17(6):440-444. doi: 10.5582/ddt.2023.01215.ABSTRACTAlzheimer's disease (AD) is a severe and progressive neurodegenerative disease, and the treatment options that are currently available are limited. The amyloid cascade hypothesis has had a significant influence in explaining the pathology underlying AD. Inhibiting the production and aggregation of amyloid-beta (Aβ) and promoting its clearance have been important strategies in the development of anti-AD drugs over the past two decades. Specifically, Aβ directed antibodies have been highly anticipated, but drug development has been fraught with obsta...
Source: Drug Discoveries and Therapeutics - January 14, 2024 Category: Drugs & Pharmacology Authors: Daoran Lu Fangzhou Dou Jianjun Gao Source Type: research
Polycystic ovary syndrome and adverse pregnancy outcomes: potential role of decidual function
This article comprehensively reviews the pathological processes of PCOS and the mechanisms involved in its impaired decidualization. In addition, we explore how PCOS increases the incidence of adverse pregnancy outcomes (APO). By gaining a better understanding of the adverse effects of PCOS on pregnancy and its specific mechanisms, we hope to provide a theoretical basis for reducing APO and improving the live birth rate among women with PCOS.PMID:38148009 | DOI:10.5582/ddt.2023.01096 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - December 26, 2023 Category: Drugs & Pharmacology Authors: Lisha Li Hanting Ge Jing Zhou Jing Wang Ling Wang Source Type: research
Polycystic ovary syndrome and adverse pregnancy outcomes: potential role of decidual function
This article comprehensively reviews the pathological processes of PCOS and the mechanisms involved in its impaired decidualization. In addition, we explore how PCOS increases the incidence of adverse pregnancy outcomes (APO). By gaining a better understanding of the adverse effects of PCOS on pregnancy and its specific mechanisms, we hope to provide a theoretical basis for reducing APO and improving the live birth rate among women with PCOS.PMID:38148009 | DOI:10.5582/ddt.2023.01096 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - December 26, 2023 Category: Drugs & Pharmacology Authors: Lisha Li Hanting Ge Jing Zhou Jing Wang Ling Wang Source Type: research
