Development of a simple high-performance liquid chromatography-ultraviolet detection method for olaparib in patients with ovarian cancer
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01074. Online ahead of print.ABSTRACTOlaparib is a small-molecule inhibitor of poly(ADP)-ribose polymerase (PARP) used as maintenance therapy for recurrent ovarian cancer and newly diagnosed advanced ovarian cancer after initial chemotherapy. An exposure-toxicity correlation has been reported between the probability of anemia, a common adverse event associated with olaparib, and the steady-state minimum plasma concentration (Cmin) as well as the predicted maximum plasma concentration (Cmax). On the other hand, olaparib exhibits high interpatient variability with regard to...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeo Yasu Ryosuke Nishijima Risa Ikuta Mikio Shirota Haruko Iwase Source Type: research
Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament
In conclusion, quercetin antagonized AGEs-induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament. And inhibiting AGEs-induced down-regulation of miR-4429/PTEN/PI3K/Akt pathway was the mechanism underlying the antagonistic effect of quercetin on AGEs-induced apoptosis.PMID:38044121 | DOI:10.5582/ddt.2023.01047 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Yizhen Sima Junwei Li Leimei Xu Chengzhen Xiao Lisha Li Ling Wang Yisong Chen Source Type: research
Evaluation of < sup > D < /sup > -amino acid oxidase activity in rat kidney using a < sup > D < /sup > -kynurenine derivative, 6-methylthio- < sup > D < /sup > -kynurenine: An in vivo microdialysis study
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01083. Online ahead of print.ABSTRACTD-Amino acid oxidase (DAO), a D-amino acid metabolizing enzyme, is reportedly associated with the psychiatric disease schizophrenia, suggesting a role for DAO inhibitors in its treatment. We have previously reported that DAO catalyzes the conversion of nonfluorescent 6-methylthio-D-kynurenine (MeS-D-KYN) to fluorescent 5-methylthiokynurenic acid (MeS-KYNA) in vitro. The present study aimed to determine the potential of MeS-D-KYN in evaluating DAO activity in vivo using renal microdialysis technique in rats. Male Sprague-Dawley rats wer...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeshi Fukushima Ayano Kansaku Maho Umino Tatsuya Sakamoto Mayu Onozato Source Type: research
Generic selection criteria for safety and patient benefit [ Ⅻ]: Comparing the physicochemical and pharmaceutical properties of brand-name and generic tulobuterol tape
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01076. Online ahead of print.ABSTRACTPhysicochemical properties (drug release, peel strength, adhesion, and stiffness) of Hokunalin® Tape (Hokunalin) and 13 generic transdermal bronchodilator patches containing tulobuterol were characterized and evaluated for comparison. Drug-release studies evaluating sustained release behavior demonstrated better performance by the drug Hokunalin, than the generics MED, YP, Sawai, and Teikoku. Hokunalin yield a 16.2% release 1 hour after initiation, 30.1% at 3 hours, 50.0% at 8 hours. In comparison, the generics MED, YP, Sawai, and Tei...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Ken-Ichi Shimokawa Kayo Yotsukura Mitsuru Nozawa Yuko Wada Fumiyoshi Ishii Source Type: research
Development of a simple high-performance liquid chromatography-ultraviolet detection method for olaparib in patients with ovarian cancer
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01074. Online ahead of print.ABSTRACTOlaparib is a small-molecule inhibitor of poly(ADP)-ribose polymerase (PARP) used as maintenance therapy for recurrent ovarian cancer and newly diagnosed advanced ovarian cancer after initial chemotherapy. An exposure-toxicity correlation has been reported between the probability of anemia, a common adverse event associated with olaparib, and the steady-state minimum plasma concentration (Cmin) as well as the predicted maximum plasma concentration (Cmax). On the other hand, olaparib exhibits high interpatient variability with regard to...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeo Yasu Ryosuke Nishijima Risa Ikuta Mikio Shirota Haruko Iwase Source Type: research
Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament
In conclusion, quercetin antagonized AGEs-induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament. And inhibiting AGEs-induced down-regulation of miR-4429/PTEN/PI3K/Akt pathway was the mechanism underlying the antagonistic effect of quercetin on AGEs-induced apoptosis.PMID:38044121 | DOI:10.5582/ddt.2023.01047 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Yizhen Sima Junwei Li Leimei Xu Chengzhen Xiao Lisha Li Ling Wang Yisong Chen Source Type: research
Evaluation of < sup > D < /sup > -amino acid oxidase activity in rat kidney using a < sup > D < /sup > -kynurenine derivative, 6-methylthio- < sup > D < /sup > -kynurenine: An in vivo microdialysis study
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01083. Online ahead of print.ABSTRACTD-Amino acid oxidase (DAO), a D-amino acid metabolizing enzyme, is reportedly associated with the psychiatric disease schizophrenia, suggesting a role for DAO inhibitors in its treatment. We have previously reported that DAO catalyzes the conversion of nonfluorescent 6-methylthio-D-kynurenine (MeS-D-KYN) to fluorescent 5-methylthiokynurenic acid (MeS-KYNA) in vitro. The present study aimed to determine the potential of MeS-D-KYN in evaluating DAO activity in vivo using renal microdialysis technique in rats. Male Sprague-Dawley rats wer...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeshi Fukushima Ayano Kansaku Maho Umino Tatsuya Sakamoto Mayu Onozato Source Type: research
Generic selection criteria for safety and patient benefit [ Ⅻ]: Comparing the physicochemical and pharmaceutical properties of brand-name and generic tulobuterol tape
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01076. Online ahead of print.ABSTRACTPhysicochemical properties (drug release, peel strength, adhesion, and stiffness) of Hokunalin® Tape (Hokunalin) and 13 generic transdermal bronchodilator patches containing tulobuterol were characterized and evaluated for comparison. Drug-release studies evaluating sustained release behavior demonstrated better performance by the drug Hokunalin, than the generics MED, YP, Sawai, and Teikoku. Hokunalin yield a 16.2% release 1 hour after initiation, 30.1% at 3 hours, 50.0% at 8 hours. In comparison, the generics MED, YP, Sawai, and Tei...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Ken-Ichi Shimokawa Kayo Yotsukura Mitsuru Nozawa Yuko Wada Fumiyoshi Ishii Source Type: research
Development of a simple high-performance liquid chromatography-ultraviolet detection method for olaparib in patients with ovarian cancer
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01074. Online ahead of print.ABSTRACTOlaparib is a small-molecule inhibitor of poly(ADP)-ribose polymerase (PARP) used as maintenance therapy for recurrent ovarian cancer and newly diagnosed advanced ovarian cancer after initial chemotherapy. An exposure-toxicity correlation has been reported between the probability of anemia, a common adverse event associated with olaparib, and the steady-state minimum plasma concentration (Cmin) as well as the predicted maximum plasma concentration (Cmax). On the other hand, olaparib exhibits high interpatient variability with regard to...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeo Yasu Ryosuke Nishijima Risa Ikuta Mikio Shirota Haruko Iwase Source Type: research
Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament
In conclusion, quercetin antagonized AGEs-induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament. And inhibiting AGEs-induced down-regulation of miR-4429/PTEN/PI3K/Akt pathway was the mechanism underlying the antagonistic effect of quercetin on AGEs-induced apoptosis.PMID:38044121 | DOI:10.5582/ddt.2023.01047 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Yizhen Sima Junwei Li Leimei Xu Chengzhen Xiao Lisha Li Ling Wang Yisong Chen Source Type: research
Evaluation of < sup > D < /sup > -amino acid oxidase activity in rat kidney using a < sup > D < /sup > -kynurenine derivative, 6-methylthio- < sup > D < /sup > -kynurenine: An in vivo microdialysis study
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01083. Online ahead of print.ABSTRACTD-Amino acid oxidase (DAO), a D-amino acid metabolizing enzyme, is reportedly associated with the psychiatric disease schizophrenia, suggesting a role for DAO inhibitors in its treatment. We have previously reported that DAO catalyzes the conversion of nonfluorescent 6-methylthio-D-kynurenine (MeS-D-KYN) to fluorescent 5-methylthiokynurenic acid (MeS-KYNA) in vitro. The present study aimed to determine the potential of MeS-D-KYN in evaluating DAO activity in vivo using renal microdialysis technique in rats. Male Sprague-Dawley rats wer...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeshi Fukushima Ayano Kansaku Maho Umino Tatsuya Sakamoto Mayu Onozato Source Type: research
Generic selection criteria for safety and patient benefit [ Ⅻ]: Comparing the physicochemical and pharmaceutical properties of brand-name and generic tulobuterol tape
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01076. Online ahead of print.ABSTRACTPhysicochemical properties (drug release, peel strength, adhesion, and stiffness) of Hokunalin® Tape (Hokunalin) and 13 generic transdermal bronchodilator patches containing tulobuterol were characterized and evaluated for comparison. Drug-release studies evaluating sustained release behavior demonstrated better performance by the drug Hokunalin, than the generics MED, YP, Sawai, and Teikoku. Hokunalin yield a 16.2% release 1 hour after initiation, 30.1% at 3 hours, 50.0% at 8 hours. In comparison, the generics MED, YP, Sawai, and Tei...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Ken-Ichi Shimokawa Kayo Yotsukura Mitsuru Nozawa Yuko Wada Fumiyoshi Ishii Source Type: research
Development of a simple high-performance liquid chromatography-ultraviolet detection method for olaparib in patients with ovarian cancer
Drug Discov Ther. 2023 Dec 3. doi: 10.5582/ddt.2023.01074. Online ahead of print.ABSTRACTOlaparib is a small-molecule inhibitor of poly(ADP)-ribose polymerase (PARP) used as maintenance therapy for recurrent ovarian cancer and newly diagnosed advanced ovarian cancer after initial chemotherapy. An exposure-toxicity correlation has been reported between the probability of anemia, a common adverse event associated with olaparib, and the steady-state minimum plasma concentration (Cmin) as well as the predicted maximum plasma concentration (Cmax). On the other hand, olaparib exhibits high interpatient variability with regard to...
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Takeo Yasu Ryosuke Nishijima Risa Ikuta Mikio Shirota Haruko Iwase Source Type: research
Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament
In conclusion, quercetin antagonized AGEs-induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament. And inhibiting AGEs-induced down-regulation of miR-4429/PTEN/PI3K/Akt pathway was the mechanism underlying the antagonistic effect of quercetin on AGEs-induced apoptosis.PMID:38044121 | DOI:10.5582/ddt.2023.01047 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - December 3, 2023 Category: Drugs & Pharmacology Authors: Yizhen Sima Junwei Li Leimei Xu Chengzhen Xiao Lisha Li Ling Wang Yisong Chen Source Type: research
Impact of anesthesia on postoperative breast cancer prognosis: A narrative review
Drug Discov Ther. 2023 Oct 31. doi: 10.5582/ddt.2023.01065. Online ahead of print.ABSTRACTThe incidence of breast cancer has exhibited an annually increasing trend, and the disease has become the most common malignant tumour worldwide. Currently, the primary treatment for breast cancer is surgical resection. However, metastatic recurrence is the main cause of cancer-related death in this patient population. Various factors are associated with breast cancer prognosis, and anaesthesia-induced changes in the tumour microenvironment have attracted increasing attention. To date, however, it remains unclear whether anaesthetic d...
Source: Drug Discoveries and Therapeutics - November 1, 2023 Category: Drugs & Pharmacology Authors: Tang Yi Guo Shanshan Chen Yao Liu Li Liu Minqiang He Renliang Wu Qiang Source Type: research
