Inhaled ciclesonide does not affect production of antibodies or elimination of virus in patients with COVID-19: Subanalysis of a multicenter, open-label randomized trial
Drug Discov Ther. 2023 Oct 30. doi: 10.5582/ddt.2023.01078. Online ahead of print.ABSTRACTDuring an earlier multicenter, open-label, randomized controlled trial designed to evaluate the effectiveness of high-dose inhaled ciclesonide in patients with asymptomatic or mild coronavirus disease 2019 (COVID-19), we observed that worsening of shadows on CT without worsening of clinical symptoms was more common with ciclesonide. The present study sought to determine if an association exists between worsening CT shadows and impaired antibody production in patients treated with inhaled ciclesonide. Eighty-nine of the 90 patients in ...
Source: Drug Discoveries and Therapeutics - October 29, 2023 Category: Drugs & Pharmacology Authors: Manabu Suzuki Akihiro Matsunaga Tohru Miyoshi-Akiyama Junko Terada-Hirashima Kenji Sadamasu Mami Nagashima Jin Takasaki Shinyu Izumi Masayuki Hojo Yukihito Ishizaka Haruhito Sugiyama Source Type: research
A pilot study comparing the disinfecting effects of commercialized stable ClO < sub > 2 < /sub > solution (free of activation) with conventional H < sub > 2 < /sub > O < sub > 2 < /sub > on dental unit waterlines in the dental practice setting
This study was designed to compare the disinfecting effects of stable 5 ppm of ClO2 solution with conventional 0.24% of H2O2 on DUWLs in dental practice. Studies of colony-forming units (CFUs), confocal laser scanning microscopy (CLSM) and scanning electron microscope (SEM) were employed for evaluation. In CFUs studies, we found that the efficiency of ClO2 was no less than those of H2O2. In the morphological studies, the stronger disinfecting effects of ClO2 was verified by both CLSM and SEM studies for removal and prevention of biofilm. Importantly, ClO2 solution achieved a better disinfecting efficiency not only at the s...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Xiaolei Zhang Jingjing Sha Zefan Huang Sisi Chen Xufei Luo Ruijun Liu Tetsuya Asakawa Qiang Zhang Source Type: research
Elevated indoleamine 2,3-dioxygenase activity is associated with endothelial dysfunction in people living with HIV and ROS production in human aortic endothelial cells in vitro
This study aimed to investigate the impact of elevated IDO activity on endothelial dysfunction in PLWH. A total of 38 PLWH, who had not previously received anti-retroviral therapy (ART), were enrolled in the study. These participants were monitored for 36 months following the initiation of ART. Measurements including plasma levels of IDO activity, markers of endothelial dysfunction, inflammatory factors, and lipids. In vitro, human aortic endothelial cells (HAEC) were exposed to interferon-γ, an IDO inhibitor, a kynurenine 3-hydroxylase (KMO) inhibitor, as well as different concentrations of kynurenine. Pre-ART, PLWH demo...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Junyang Yang Rentian Cai Jingna Xun Renfang Zhang Li Liu Yinzhong Shen Tangkai Qi Zhenyan Wang Wei Song Yang Tang Jianjun Sun Shuibao Xu Bihe Zhao Hongzhou Lu Jun Chen Source Type: research
A pilot study comparing the disinfecting effects of commercialized stable ClO < sub > 2 < /sub > solution (free of activation) with conventional H < sub > 2 < /sub > O < sub > 2 < /sub > on dental unit waterlines in the dental practice setting
This study was designed to compare the disinfecting effects of stable 5 ppm of ClO2 solution with conventional 0.24% of H2O2 on DUWLs in dental practice. Studies of colony-forming units (CFUs), confocal laser scanning microscopy (CLSM) and scanning electron microscope (SEM) were employed for evaluation. In CFUs studies, we found that the efficiency of ClO2 was no less than those of H2O2. In the morphological studies, the stronger disinfecting effects of ClO2 was verified by both CLSM and SEM studies for removal and prevention of biofilm. Importantly, ClO2 solution achieved a better disinfecting efficiency not only at the s...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Xiaolei Zhang Jingjing Sha Zefan Huang Sisi Chen Xufei Luo Ruijun Liu Tetsuya Asakawa Qiang Zhang Source Type: research
Elevated indoleamine 2,3-dioxygenase activity is associated with endothelial dysfunction in people living with HIV and ROS production in human aortic endothelial cells in vitro
This study aimed to investigate the impact of elevated IDO activity on endothelial dysfunction in PLWH. A total of 38 PLWH, who had not previously received anti-retroviral therapy (ART), were enrolled in the study. These participants were monitored for 36 months following the initiation of ART. Measurements including plasma levels of IDO activity, markers of endothelial dysfunction, inflammatory factors, and lipids. In vitro, human aortic endothelial cells (HAEC) were exposed to interferon-γ, an IDO inhibitor, a kynurenine 3-hydroxylase (KMO) inhibitor, as well as different concentrations of kynurenine. Pre-ART, PLWH demo...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Junyang Yang Rentian Cai Jingna Xun Renfang Zhang Li Liu Yinzhong Shen Tangkai Qi Zhenyan Wang Wei Song Yang Tang Jianjun Sun Shuibao Xu Bihe Zhao Hongzhou Lu Jun Chen Source Type: research
A pilot study comparing the disinfecting effects of commercialized stable ClO < sub > 2 < /sub > solution (free of activation) with conventional H < sub > 2 < /sub > O < sub > 2 < /sub > on dental unit waterlines in the dental practice setting
This study was designed to compare the disinfecting effects of stable 5 ppm of ClO2 solution with conventional 0.24% of H2O2 on DUWLs in dental practice. Studies of colony-forming units (CFUs), confocal laser scanning microscopy (CLSM) and scanning electron microscope (SEM) were employed for evaluation. In CFUs studies, we found that the efficiency of ClO2 was no less than those of H2O2. In the morphological studies, the stronger disinfecting effects of ClO2 was verified by both CLSM and SEM studies for removal and prevention of biofilm. Importantly, ClO2 solution achieved a better disinfecting efficiency not only at the s...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Xiaolei Zhang Jingjing Sha Zefan Huang Sisi Chen Xufei Luo Ruijun Liu Tetsuya Asakawa Qiang Zhang Source Type: research
Elevated indoleamine 2,3-dioxygenase activity is associated with endothelial dysfunction in people living with HIV and ROS production in human aortic endothelial cells in vitro
This study aimed to investigate the impact of elevated IDO activity on endothelial dysfunction in PLWH. A total of 38 PLWH, who had not previously received anti-retroviral therapy (ART), were enrolled in the study. These participants were monitored for 36 months following the initiation of ART. Measurements including plasma levels of IDO activity, markers of endothelial dysfunction, inflammatory factors, and lipids. In vitro, human aortic endothelial cells (HAEC) were exposed to interferon-γ, an IDO inhibitor, a kynurenine 3-hydroxylase (KMO) inhibitor, as well as different concentrations of kynurenine. Pre-ART, PLWH demo...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Junyang Yang Rentian Cai Jingna Xun Renfang Zhang Li Liu Yinzhong Shen Tangkai Qi Zhenyan Wang Wei Song Yang Tang Jianjun Sun Shuibao Xu Bihe Zhao Hongzhou Lu Jun Chen Source Type: research
