Evolving immune evasion and transmissibility of SARS-CoV-2: The emergence of JN.1 variant and its global impact
Drug Discov Ther. 2024 Feb 22. doi: 10.5582/ddt.2024.01008. Online ahead of print.ABSTRACTThe continuous evolution of SARS-CoV-2 variants constitutes a significant impediment to the public health. The World Health Organization (WHO) has designated the SARS-CoV-2 variant JN.1, which has evolved from its progenitor BA.2.86, as a Variant of Interest (VOI) in light of its enhanced immune evasion and transmissibility. The proliferating dissemination of JN.1 globally accentuates its competitive superiority and the potential to instigate fresh surges of infection, notably among cohorts previously infected by antecedent variants. ...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Guanyong Ou Yang Yang Shengjie Zhang Shiyu Niu Qingxian Cai Yingxia Liu Hongzhou Lu Source Type: research
Astragalus root increases Treg and Th17 involvement in embryo implantation and pregnancy maintenance by decreasing CTLA-4 < sup > + < /sup > Tregs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01100. Online ahead of print.ABSTRACTMaintenance of pregnancy is highly dependent on the maternal immune system. High levels of regulatory T cells (Tregs) accumulate in the maternal placenta to suppress immunoreactivity against fetal antigens. We assessed whether Astragalus root (AsR) and AsR-containing Kampo medicines modulate immunoreactivity and thereby increase mouse litter size. AsR-exposed murine splenocytes exhibited significantly increased IL-2 secretion. In AsR-exposed mice, total Tregs were significantly increased, whereas cytotoxic T lymphocyte antigen 4 (CTLA...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Kyoko Kobayashi Kenroh Sasaki Source Type: research
Comparison of the physicochemical properties of branded and generic glucose-added maintenance hypotonic infusion fluids to assess the potential for phlebitis and incompatibility with other drugs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01091. Online ahead of print.ABSTRACTIn Japan, the switch from branded to generic infusion fluids has been promoted as a national policy. Recently, as generic products have been in short supply, the switch from generic to branded infusion fluids has increased. However, certain additives for injectable infusion fluids, such as nonvolatile acids like acetic acid and hydrochloric acid, are not required to be listed in the package insert. We hypothesized that the addition of nonvolatile acids may be one of the reasons for the differences in physicochemical properties between...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Sawako Takei Soh Katsuyama Yusuke Hori Source Type: research
Inhibitory effects of kaempferol, quercetin and luteolin on the replication of human parainfluenza virus type 2 in vitro
In conclusion, the three flavonoids inhibited virus replication by the inhibition of genome, mRNA and protein syntheses, and in addition to those, by the disruption of cytoskeleton in vitro.PMID:38382931 | DOI:10.5582/ddt.2023.01099 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Kae Sakai-Sugino Jun Uematsu Hidetaka Yamamoto Sahoko Kihira Mitsuo Kawano Miwako Nishio Masato Tsurudome Hidehisa Sekijima Myles O'Brien Hiroshi Komada Source Type: research
PD-1/PD-L1 inhibitors associated hypophysitis: An analysis from the FAERS database and case reports
Drug Discov Ther. 2024 Feb 20. doi: 10.5582/ddt.2023.01092. Online ahead of print.ABSTRACTTo get a thorough understanding of PD-1/L1 inhibitor-related hypophysitis (PD-1/L1-irH), we utilized a combination of disproportionality analysis and case analysis to comprehensively characterize the clinical features of PD-1/L1-irH. Significant signals of hypophysitis were detected for all PD-1/PD-L1 inhibitors in the FAERS (FDA Adverse Event Reporting System). As revealed by both FAERS and the case analysis, PD-1/L1-irH occurred more commonly in males, PD-1 inhibitors users and patients older than 65 years. The median onset time was...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Shanshan Chen Linqi Ouyang Lian Li Yuyang Xiao Shengfeng Wang Source Type: research
Evolving immune evasion and transmissibility of SARS-CoV-2: The emergence of JN.1 variant and its global impact
Drug Discov Ther. 2024 Feb 22. doi: 10.5582/ddt.2024.01008. Online ahead of print.ABSTRACTThe continuous evolution of SARS-CoV-2 variants constitutes a significant impediment to the public health. The World Health Organization (WHO) has designated the SARS-CoV-2 variant JN.1, which has evolved from its progenitor BA.2.86, as a Variant of Interest (VOI) in light of its enhanced immune evasion and transmissibility. The proliferating dissemination of JN.1 globally accentuates its competitive superiority and the potential to instigate fresh surges of infection, notably among cohorts previously infected by antecedent variants. ...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Guanyong Ou Yang Yang Shengjie Zhang Shiyu Niu Qingxian Cai Yingxia Liu Hongzhou Lu Source Type: research
Astragalus root increases Treg and Th17 involvement in embryo implantation and pregnancy maintenance by decreasing CTLA-4 < sup > + < /sup > Tregs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01100. Online ahead of print.ABSTRACTMaintenance of pregnancy is highly dependent on the maternal immune system. High levels of regulatory T cells (Tregs) accumulate in the maternal placenta to suppress immunoreactivity against fetal antigens. We assessed whether Astragalus root (AsR) and AsR-containing Kampo medicines modulate immunoreactivity and thereby increase mouse litter size. AsR-exposed murine splenocytes exhibited significantly increased IL-2 secretion. In AsR-exposed mice, total Tregs were significantly increased, whereas cytotoxic T lymphocyte antigen 4 (CTLA...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Kyoko Kobayashi Kenroh Sasaki Source Type: research
Comparison of the physicochemical properties of branded and generic glucose-added maintenance hypotonic infusion fluids to assess the potential for phlebitis and incompatibility with other drugs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01091. Online ahead of print.ABSTRACTIn Japan, the switch from branded to generic infusion fluids has been promoted as a national policy. Recently, as generic products have been in short supply, the switch from generic to branded infusion fluids has increased. However, certain additives for injectable infusion fluids, such as nonvolatile acids like acetic acid and hydrochloric acid, are not required to be listed in the package insert. We hypothesized that the addition of nonvolatile acids may be one of the reasons for the differences in physicochemical properties between...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Sawako Takei Soh Katsuyama Yusuke Hori Source Type: research
Inhibitory effects of kaempferol, quercetin and luteolin on the replication of human parainfluenza virus type 2 in vitro
In conclusion, the three flavonoids inhibited virus replication by the inhibition of genome, mRNA and protein syntheses, and in addition to those, by the disruption of cytoskeleton in vitro.PMID:38382931 | DOI:10.5582/ddt.2023.01099 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Kae Sakai-Sugino Jun Uematsu Hidetaka Yamamoto Sahoko Kihira Mitsuo Kawano Miwako Nishio Masato Tsurudome Hidehisa Sekijima Myles O'Brien Hiroshi Komada Source Type: research
PD-1/PD-L1 inhibitors associated hypophysitis: An analysis from the FAERS database and case reports
Drug Discov Ther. 2024 Feb 20. doi: 10.5582/ddt.2023.01092. Online ahead of print.ABSTRACTTo get a thorough understanding of PD-1/L1 inhibitor-related hypophysitis (PD-1/L1-irH), we utilized a combination of disproportionality analysis and case analysis to comprehensively characterize the clinical features of PD-1/L1-irH. Significant signals of hypophysitis were detected for all PD-1/PD-L1 inhibitors in the FAERS (FDA Adverse Event Reporting System). As revealed by both FAERS and the case analysis, PD-1/L1-irH occurred more commonly in males, PD-1 inhibitors users and patients older than 65 years. The median onset time was...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Shanshan Chen Linqi Ouyang Lian Li Yuyang Xiao Shengfeng Wang Source Type: research
Evolving immune evasion and transmissibility of SARS-CoV-2: The emergence of JN.1 variant and its global impact
Drug Discov Ther. 2024 Feb 22. doi: 10.5582/ddt.2024.01008. Online ahead of print.ABSTRACTThe continuous evolution of SARS-CoV-2 variants constitutes a significant impediment to the public health. The World Health Organization (WHO) has designated the SARS-CoV-2 variant JN.1, which has evolved from its progenitor BA.2.86, as a Variant of Interest (VOI) in light of its enhanced immune evasion and transmissibility. The proliferating dissemination of JN.1 globally accentuates its competitive superiority and the potential to instigate fresh surges of infection, notably among cohorts previously infected by antecedent variants. ...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Guanyong Ou Yang Yang Shengjie Zhang Shiyu Niu Qingxian Cai Yingxia Liu Hongzhou Lu Source Type: research
Astragalus root increases Treg and Th17 involvement in embryo implantation and pregnancy maintenance by decreasing CTLA-4 < sup > + < /sup > Tregs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01100. Online ahead of print.ABSTRACTMaintenance of pregnancy is highly dependent on the maternal immune system. High levels of regulatory T cells (Tregs) accumulate in the maternal placenta to suppress immunoreactivity against fetal antigens. We assessed whether Astragalus root (AsR) and AsR-containing Kampo medicines modulate immunoreactivity and thereby increase mouse litter size. AsR-exposed murine splenocytes exhibited significantly increased IL-2 secretion. In AsR-exposed mice, total Tregs were significantly increased, whereas cytotoxic T lymphocyte antigen 4 (CTLA...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Kyoko Kobayashi Kenroh Sasaki Source Type: research
Comparison of the physicochemical properties of branded and generic glucose-added maintenance hypotonic infusion fluids to assess the potential for phlebitis and incompatibility with other drugs
Drug Discov Ther. 2024 Feb 21. doi: 10.5582/ddt.2023.01091. Online ahead of print.ABSTRACTIn Japan, the switch from branded to generic infusion fluids has been promoted as a national policy. Recently, as generic products have been in short supply, the switch from generic to branded infusion fluids has increased. However, certain additives for injectable infusion fluids, such as nonvolatile acids like acetic acid and hydrochloric acid, are not required to be listed in the package insert. We hypothesized that the addition of nonvolatile acids may be one of the reasons for the differences in physicochemical properties between...
Source: Drug Discoveries and Therapeutics - February 21, 2024 Category: Drugs & Pharmacology Authors: Sawako Takei Soh Katsuyama Yusuke Hori Source Type: research
Usefulness of a new immunochromatographic assay using fluorescent silica nanoparticles for serodiagnosis of Thai patients with amebiasis
Drug Discov Ther. 2024 Feb 15. doi: 10.5582/ddt.2023.01102. Online ahead of print.ABSTRACTA fluorescence immunochromatography (FIC) kit was developed recently using fluorescent silica nanoparticles coated with a recombinant C-terminal fragment of the surface lectin intermediate subunit (C-Igl) of Entamoeba histolytica to establish rapid serodiagnosis of amebiasis. We further evaluated the system using serum samples from 52 Thai patients with amebiasis. Of the patients, 50 (96%) tested positive using FIC. The samples were also tested using enzyme-linked immunosorbent assay (ELISA) with C-Igl as the antigen. Two samples were...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Azumi Kakino Urassaya Pattanawong Napaporn Kuamsab Tatsuya Imai Chaturong Putaporntip Satomi Asai Xunjia Cheng Somchai Jongwutiwes Hiroshi Tachibana Source Type: research
Quantitative parameters of contrast-enhanced ultrasound effectively promote the prediction of cervical lymph node metastasis in papillary thyroid carcinoma
In conclusion, PI has significance in predicting CLNM for PTC > 10 mm; however, it is not helpful for PTC ≤ 10 mm.PMID:38355122 | DOI:10.5582/ddt.2023.01095 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Biao Su Lisha Li Yingchun Liu Hui Liu Jia Zhan Qiliang Chai Liang Fang Ling Wang Lin Chen Source Type: research
