FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling
Drug Discov Ther. 2023 Sep 22. doi: 10.5582/ddt.2023.01036. Online ahead of print.ABSTRACTLipid metabolism plays an important role in the growth and development of tumors. However, the role of lipid metabolism in gallbladder cancer (GBC) has not been clearly clarified. Here, we demonstrated that fatty acid synthase (FASN), a key enzyme in de novo fatty acid biosynthesis, had upregulated expression in GBC samples both at protein and mRNA levels. Analysis of clinical data indicated the association between elevated FASN expression and poorer histology grades. Furthermore, FASN activity impairment through FASN knockdown or tre...
Source: Drug Discoveries and Therapeutics - September 24, 2023 Category: Drugs & Pharmacology Authors: Haihong Cheng Yuxin Sun Xiaopeng Yu Di Zhou Jun Ding Shouhua Wang Fei Ma Source Type: research
Effectiveness of an artificial intelligence-based training and monitoring system in prevention of nosocomial infections: A pilot study of hospital-based data
This study suggested the key role of using PPE in controlling and preventing NIs. Data preliminarily proved that appropriate donning/removing PPE may help to reduce the risk of NIs. In addition, the newest computerized technologies, such as AI, have proven to be useful in controlling and preventing NIs. These findings should helpful to formulate a better strategy against NIs in the future.PMID:37673650 | DOI:10.5582/ddt.2023.01068 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - September 6, 2023 Category: Drugs & Pharmacology Authors: Ting Huang Yue Ma Shaxi Li Jianchao Ran Yifan Xu Tetsuya Asakawa Hongzhou Lu Source Type: research
