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A pilot study comparing the disinfecting effects of commercialized stable ClO 2 solution (free of activation) with conventional H 2 O 2 on dental unit waterlines in the dental practice setting
This study was designed to compare the disinfecting effects of stable 5 ppm of ClO2 solution with conventional 0.24% of H2O2 on DUWLs in dental practice. Studies of colony-forming units (CFUs), confocal laser scanning microscopy (CLSM) and scanning electron microscope (SEM) were employed for evaluation. In CFUs studies, we found that the efficiency of ClO2 was no less than those of H2O2. In the morphological studies, the stronger disinfecting effects of ClO2 was verified by both CLSM and SEM studies for removal and prevention of biofilm. Importantly, ClO2 solution achieved a better disinfecting efficiency not only at the s...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Xiaolei Zhang Jingjing Sha Zefan Huang Sisi Chen Xufei Luo Ruijun Liu Tetsuya Asakawa Qiang Zhang Source Type: research

Elevated indoleamine 2,3-dioxygenase activity is associated with endothelial dysfunction in people living with HIV and ROS production in human aortic endothelial cells in vitro
This study aimed to investigate the impact of elevated IDO activity on endothelial dysfunction in PLWH. A total of 38 PLWH, who had not previously received anti-retroviral therapy (ART), were enrolled in the study. These participants were monitored for 36 months following the initiation of ART. Measurements including plasma levels of IDO activity, markers of endothelial dysfunction, inflammatory factors, and lipids. In vitro, human aortic endothelial cells (HAEC) were exposed to interferon-γ, an IDO inhibitor, a kynurenine 3-hydroxylase (KMO) inhibitor, as well as different concentrations of kynurenine. Pre-ART, PLWH demo...
Source: Drug Discoveries and Therapeutics - October 25, 2023 Category: Drugs & Pharmacology Authors: Junyang Yang Rentian Cai Jingna Xun Renfang Zhang Li Liu Yinzhong Shen Tangkai Qi Zhenyan Wang Wei Song Yang Tang Jianjun Sun Shuibao Xu Bihe Zhao Hongzhou Lu Jun Chen Source Type: research

Hypofibrinolytic phenotype in Tsumura Suzuki Obese Diabetes (TSOD) mice unrelated to hyperglycemia
Drug Discov Ther. 2023 Oct 14. doi: 10.5582/ddt.2023.01064. Online ahead of print.ABSTRACTObesity and diabetes mellitus are associated with increased risk of arterial thrombosis and venous thromboembolism. Tsumura Suzuki Obese Diabetes (TSOD) mice are useful models for elucidating the molecular mechanisms of these diseases. We investigated normoglycemic [Ng]-TSOD mice with a metabolic abnormality that was accompanied by a coagulative and fibrinolytic state with a phenotype that distinctly differed from that of standard TSOD mice. As in TSOD mice, plasminogen activation inhibitor-1 (PAI-1) that inhibits fibrinolysis was sub...
Source: Drug Discoveries and Therapeutics - October 15, 2023 Category: Drugs & Pharmacology Authors: Naoki Ohkura Riyo Morimoto-Kamata Yuichi Kamikubo Yoshihisa Takahashi Katsutaka Oishi Source Type: research

Effects of plant-based copper nanoparticles on the elimination of ciprofloxacin
In conclusion, the developed GM-CuNPs have excellent CIP removal efficiency. These synthesized GM-CuNPs are expected to be environmentally friendly for the removal of antibiotics and other drugs.PMID:37839876 | DOI:10.5582/ddt.2023.01057 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 15, 2023 Category: Drugs & Pharmacology Authors: Tanongsak Sassa-Deepaeng Wachira Yodthong Nattakanwadee Khumpirapang Songyot Anuchapreeda Siriporn Okonogi Source Type: research