Effects of plant-based copper nanoparticles on the elimination of ciprofloxacin
In conclusion, the developed GM-CuNPs have excellent CIP removal efficiency. These synthesized GM-CuNPs are expected to be environmentally friendly for the removal of antibiotics and other drugs.PMID:37839876 | DOI:10.5582/ddt.2023.01057 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 15, 2023 Category: Drugs & Pharmacology Authors: Tanongsak Sassa-Deepaeng Wachira Yodthong Nattakanwadee Khumpirapang Songyot Anuchapreeda Siriporn Okonogi Source Type: research
Hypofibrinolytic phenotype in Tsumura Suzuki Obese Diabetes (TSOD) mice unrelated to hyperglycemia
Drug Discov Ther. 2023 Oct 14. doi: 10.5582/ddt.2023.01064. Online ahead of print.ABSTRACTObesity and diabetes mellitus are associated with increased risk of arterial thrombosis and venous thromboembolism. Tsumura Suzuki Obese Diabetes (TSOD) mice are useful models for elucidating the molecular mechanisms of these diseases. We investigated normoglycemic [Ng]-TSOD mice with a metabolic abnormality that was accompanied by a coagulative and fibrinolytic state with a phenotype that distinctly differed from that of standard TSOD mice. As in TSOD mice, plasminogen activation inhibitor-1 (PAI-1) that inhibits fibrinolysis was sub...
Source: Drug Discoveries and Therapeutics - October 15, 2023 Category: Drugs & Pharmacology Authors: Naoki Ohkura Riyo Morimoto-Kamata Yuichi Kamikubo Yoshihisa Takahashi Katsutaka Oishi Source Type: research
Effects of plant-based copper nanoparticles on the elimination of ciprofloxacin
In conclusion, the developed GM-CuNPs have excellent CIP removal efficiency. These synthesized GM-CuNPs are expected to be environmentally friendly for the removal of antibiotics and other drugs.PMID:37839876 | DOI:10.5582/ddt.2023.01057 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 15, 2023 Category: Drugs & Pharmacology Authors: Tanongsak Sassa-Deepaeng Wachira Yodthong Nattakanwadee Khumpirapang Songyot Anuchapreeda Siriporn Okonogi Source Type: research
Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01053. Online ahead of print.ABSTRACTAcute viral pharyngitis is a self-limited disease but the symptoms, a sore throat in particular, can affect one's quality of life. Medicine for symptom relief is the main treatment. Recently, many studies have shown that Andrographis paniculata was efficacious in treating many diseases, including upper respiratory infections. However, adverse reactions to systemic intake are a concern. Therefore, A. paniculata spray is intended to reduce systemic adverse reactions and provide patients with more comfort as its local use. This randomize...
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Risa Okonogi Vich Thampanya Siriporn Okonogi Source Type: research
Complete trisomy 9 detected by noninvasive prenatal testing and confirmed by amniocentesis
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01051. Online ahead of print.ABSTRACTComplete chromosome 9 trisomy (T9) is a rare and fatal chromosomal disorder. We performed non-invasive prenatal testing (NIPT) in a patient with threatened abortion symptoms and found that the fetal was at risk for complete chromosome 9 trisomy. This shows that NIPT has certain accuracy in detecting trisomy of chromosome 9, which provide options for prenatal diagnosis of rare chromosomal abnormalities.PMID:37821384 | DOI:10.5582/ddt.2023.01051 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Feixiang Huang Jing Zhou Zheyun Xu Qing Qi Hongmei Sun Lei Chen Ling Wang Source Type: research
Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01053. Online ahead of print.ABSTRACTAcute viral pharyngitis is a self-limited disease but the symptoms, a sore throat in particular, can affect one's quality of life. Medicine for symptom relief is the main treatment. Recently, many studies have shown that Andrographis paniculata was efficacious in treating many diseases, including upper respiratory infections. However, adverse reactions to systemic intake are a concern. Therefore, A. paniculata spray is intended to reduce systemic adverse reactions and provide patients with more comfort as its local use. This randomize...
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Risa Okonogi Vich Thampanya Siriporn Okonogi Source Type: research
Complete trisomy 9 detected by noninvasive prenatal testing and confirmed by amniocentesis
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01051. Online ahead of print.ABSTRACTComplete chromosome 9 trisomy (T9) is a rare and fatal chromosomal disorder. We performed non-invasive prenatal testing (NIPT) in a patient with threatened abortion symptoms and found that the fetal was at risk for complete chromosome 9 trisomy. This shows that NIPT has certain accuracy in detecting trisomy of chromosome 9, which provide options for prenatal diagnosis of rare chromosomal abnormalities.PMID:37821384 | DOI:10.5582/ddt.2023.01051 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Feixiang Huang Jing Zhou Zheyun Xu Qing Qi Hongmei Sun Lei Chen Ling Wang Source Type: research
Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01053. Online ahead of print.ABSTRACTAcute viral pharyngitis is a self-limited disease but the symptoms, a sore throat in particular, can affect one's quality of life. Medicine for symptom relief is the main treatment. Recently, many studies have shown that Andrographis paniculata was efficacious in treating many diseases, including upper respiratory infections. However, adverse reactions to systemic intake are a concern. Therefore, A. paniculata spray is intended to reduce systemic adverse reactions and provide patients with more comfort as its local use. This randomize...
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Risa Okonogi Vich Thampanya Siriporn Okonogi Source Type: research
Complete trisomy 9 detected by noninvasive prenatal testing and confirmed by amniocentesis
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01051. Online ahead of print.ABSTRACTComplete chromosome 9 trisomy (T9) is a rare and fatal chromosomal disorder. We performed non-invasive prenatal testing (NIPT) in a patient with threatened abortion symptoms and found that the fetal was at risk for complete chromosome 9 trisomy. This shows that NIPT has certain accuracy in detecting trisomy of chromosome 9, which provide options for prenatal diagnosis of rare chromosomal abnormalities.PMID:37821384 | DOI:10.5582/ddt.2023.01051 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Feixiang Huang Jing Zhou Zheyun Xu Qing Qi Hongmei Sun Lei Chen Ling Wang Source Type: research
Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01053. Online ahead of print.ABSTRACTAcute viral pharyngitis is a self-limited disease but the symptoms, a sore throat in particular, can affect one's quality of life. Medicine for symptom relief is the main treatment. Recently, many studies have shown that Andrographis paniculata was efficacious in treating many diseases, including upper respiratory infections. However, adverse reactions to systemic intake are a concern. Therefore, A. paniculata spray is intended to reduce systemic adverse reactions and provide patients with more comfort as its local use. This randomize...
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Risa Okonogi Vich Thampanya Siriporn Okonogi Source Type: research
Complete trisomy 9 detected by noninvasive prenatal testing and confirmed by amniocentesis
Drug Discov Ther. 2023 Oct 11. doi: 10.5582/ddt.2023.01051. Online ahead of print.ABSTRACTComplete chromosome 9 trisomy (T9) is a rare and fatal chromosomal disorder. We performed non-invasive prenatal testing (NIPT) in a patient with threatened abortion symptoms and found that the fetal was at risk for complete chromosome 9 trisomy. This shows that NIPT has certain accuracy in detecting trisomy of chromosome 9, which provide options for prenatal diagnosis of rare chromosomal abnormalities.PMID:37821384 | DOI:10.5582/ddt.2023.01051 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Feixiang Huang Jing Zhou Zheyun Xu Qing Qi Hongmei Sun Lei Chen Ling Wang Source Type: research
EQUIBIND: A geometric deep learning-based protein-ligand binding prediction method
Drug Discov Ther. 2023 Sep 26. doi: 10.5582/ddt.2023.01063. Online ahead of print.ABSTRACTStructure-based virtual screening plays a critical role in drug discovery. However, numerous docking programs, such as AutoDock Vina and Glide, are time-consuming due to the necessity of generating numerous molecular conformations and executing steps like scoring, ranking, and refinement for the ligand-receptor complexes. Consequently, achieving rapid and reliable virtual screening remains a noteworthy challenge. Recently, a team of researchers from Massachusetts Institute of Technology, led by Stärk et al., developed an SE(3)-equiva...
Source: Drug Discoveries and Therapeutics - September 28, 2023 Category: Drugs & Pharmacology Authors: Yuze Li Li Li Shuang Wang Xiaowen Tang Source Type: research
