The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance
DNA Repair (Amst). 2023 Aug;128:103526. doi: 10.1016/j.dnarep.2023.103526. Epub 2023 Jun 17.ABSTRACTDNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are responsible fo...
Source: DNA Repair - July 5, 2023 Category: Genetics & Stem Cells Authors: Mokhtar Jawad Al-Imam Uday Abdul-Reda Hussein Fadhil Faez Sead Ayoob Murtadha Alshaikh Faqri Shereen M Mekkey Abdullah Jalel Khazel Haider Abdulkareem Almashhadani Source Type: research
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance
DNA Repair (Amst). 2023 Aug;128:103526. doi: 10.1016/j.dnarep.2023.103526. Epub 2023 Jun 17.ABSTRACTDNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are responsible fo...
Source: DNA Repair - July 5, 2023 Category: Genetics & Stem Cells Authors: Mokhtar Jawad Al-Imam Uday Abdul-Reda Hussein Fadhil Faez Sead Ayoob Murtadha Alshaikh Faqri Shereen M Mekkey Abdullah Jalel Khazel Haider Abdulkareem Almashhadani Source Type: research
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance
DNA Repair (Amst). 2023 Jun 17;128:103526. doi: 10.1016/j.dnarep.2023.103526. Online ahead of print.ABSTRACTDNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are respon...
Source: DNA Repair - July 5, 2023 Category: Genetics & Stem Cells Authors: Mokhtar Jawad Al-Imam Uday Abdul-Reda Hussein Fadhil Faez Sead Ayoob Murtadha Alshaikh Faqri Shereen M Mekkey Abdullah Jalel Khazel Haider Abdulkareem Almashhadani Source Type: research
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures
DNA Repair (Amst). 2023 Jun 24;128:103528. doi: 10.1016/j.dnarep.2023.103528. Online ahead of print.ABSTRACTDNA repair pathways are tightly regulated processes that recognize specific hallmarks of DNA damage and coordinate lesion repair through discrete mechanisms, all within the context of a three-dimensional chromatin landscape. Dysregulation or malfunction of any one of the protein constituents in these pathways can contribute to aging and a variety of diseases. While the collective action of these many proteins is what drives DNA repair on the organismal scale, it is the interactions between individual proteins and DNA...
Source: DNA Repair - July 1, 2023 Category: Genetics & Stem Cells Authors: Elizabeth Marie Irvin Hong Wang Source Type: research
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures
DNA Repair (Amst). 2023 Jun 24;128:103528. doi: 10.1016/j.dnarep.2023.103528. Online ahead of print.ABSTRACTDNA repair pathways are tightly regulated processes that recognize specific hallmarks of DNA damage and coordinate lesion repair through discrete mechanisms, all within the context of a three-dimensional chromatin landscape. Dysregulation or malfunction of any one of the protein constituents in these pathways can contribute to aging and a variety of diseases. While the collective action of these many proteins is what drives DNA repair on the organismal scale, it is the interactions between individual proteins and DNA...
Source: DNA Repair - July 1, 2023 Category: Genetics & Stem Cells Authors: Elizabeth Marie Irvin Hong Wang Source Type: research
