Telomeres as hotspots for innate immunity and inflammation
DNA Repair (Amst). 2023 Nov 5;133:103591. doi: 10.1016/j.dnarep.2023.103591. Online ahead of print.ABSTRACTAging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cellular and molecular hallmarks that contribute to this biological process. This review focuses on two factors, namely telomere dysfunction and inflammation, which have emerged as crucial contributors to the aging process. We...
Source: DNA Repair - November 11, 2023 Category: Genetics & Stem Cells Authors: Joe Nassour Sara Przetocka Jan Karlseder Source Type: research

Telomeres as hotspots for innate immunity and inflammation
DNA Repair (Amst). 2023 Nov 5;133:103591. doi: 10.1016/j.dnarep.2023.103591. Online ahead of print.ABSTRACTAging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cellular and molecular hallmarks that contribute to this biological process. This review focuses on two factors, namely telomere dysfunction and inflammation, which have emerged as crucial contributors to the aging process. We...
Source: DNA Repair - November 11, 2023 Category: Genetics & Stem Cells Authors: Joe Nassour Sara Przetocka Jan Karlseder Source Type: research

Telomeres as hotspots for innate immunity and inflammation
DNA Repair (Amst). 2023 Nov 5;133:103591. doi: 10.1016/j.dnarep.2023.103591. Online ahead of print.ABSTRACTAging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cellular and molecular hallmarks that contribute to this biological process. This review focuses on two factors, namely telomere dysfunction and inflammation, which have emerged as crucial contributors to the aging process. We...
Source: DNA Repair - November 11, 2023 Category: Genetics & Stem Cells Authors: Joe Nassour Sara Przetocka Jan Karlseder Source Type: research

Telomeres as hotspots for innate immunity and inflammation
DNA Repair (Amst). 2023 Nov 5;133:103591. doi: 10.1016/j.dnarep.2023.103591. Online ahead of print.ABSTRACTAging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cellular and molecular hallmarks that contribute to this biological process. This review focuses on two factors, namely telomere dysfunction and inflammation, which have emerged as crucial contributors to the aging process. We...
Source: DNA Repair - November 11, 2023 Category: Genetics & Stem Cells Authors: Joe Nassour Sara Przetocka Jan Karlseder Source Type: research

Regulation of DNA damage-induced HLA class I presentation
DNA Repair (Amst). 2023 Nov 1;132:103590. doi: 10.1016/j.dnarep.2023.103590. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICI) are cancer therapies that restore anti-tumor immunity; however, only a small percentage of patients have been completely cured by ICI alone. Multiple approaches in combination with other modalities have been used to improve the efficacy of ICI therapy. Among conventional cancer treatments, radiotherapy or DNA damage-based chemotherapy is a promising candidate as a partner of ICI because DNA damage signaling potentially stimulates immune activities turning the tumor's immune environme...
Source: DNA Repair - November 9, 2023 Category: Genetics & Stem Cells Authors: Yuki Uchihara Atsushi Shibata Source Type: research

Regulation of DNA damage-induced HLA class I presentation
DNA Repair (Amst). 2023 Nov 1;132:103590. doi: 10.1016/j.dnarep.2023.103590. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICI) are cancer therapies that restore anti-tumor immunity; however, only a small percentage of patients have been completely cured by ICI alone. Multiple approaches in combination with other modalities have been used to improve the efficacy of ICI therapy. Among conventional cancer treatments, radiotherapy or DNA damage-based chemotherapy is a promising candidate as a partner of ICI because DNA damage signaling potentially stimulates immune activities turning the tumor's immune environme...
Source: DNA Repair - November 9, 2023 Category: Genetics & Stem Cells Authors: Yuki Uchihara Atsushi Shibata Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research

Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
DNA Repair (Amst). 2023 Oct 18;132:103583. doi: 10.1016/j.dnarep.2023.103583. Online ahead of print.ABSTRACTEukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is no...
Source: DNA Repair - October 23, 2023 Category: Genetics & Stem Cells Authors: Mateusz Gregorczyk Eileen E Parkes Source Type: research