Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine
DNA Repair (Amst). 2024 Mar 5;137:103668. doi: 10.1016/j.dnarep.2024.103668. Online ahead of print.ABSTRACTAlovudine is a chain-terminating nucleoside analog (CTNA) that is frequently used as an antiviral and anticancer agent. Generally, CTNAs inhibit DNA replication after their incorporation into nascent DNA during DNA synthesis by suppressing subsequent polymerization, which restricts the proliferation of viruses and cancer cells. Alovudine is a thymidine analog used as an antiviral drug. However, the mechanisms underlying the removal of alovudine and DNA damage tolerance pathways involved in cellular resistance to alovu...
Source: DNA Repair - March 9, 2024 Category: Genetics & Stem Cells Authors: Md Bayejid Hosen Ryotaro Kawasumi Kouji Hirota Source Type: research
Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine
DNA Repair (Amst). 2024 Mar 5;137:103668. doi: 10.1016/j.dnarep.2024.103668. Online ahead of print.ABSTRACTAlovudine is a chain-terminating nucleoside analog (CTNA) that is frequently used as an antiviral and anticancer agent. Generally, CTNAs inhibit DNA replication after their incorporation into nascent DNA during DNA synthesis by suppressing subsequent polymerization, which restricts the proliferation of viruses and cancer cells. Alovudine is a thymidine analog used as an antiviral drug. However, the mechanisms underlying the removal of alovudine and DNA damage tolerance pathways involved in cellular resistance to alovu...
Source: DNA Repair - March 9, 2024 Category: Genetics & Stem Cells Authors: Md Bayejid Hosen Ryotaro Kawasumi Kouji Hirota Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Apr;136:103645. doi: 10.1016/j.dnarep.2024.103645. Epub 2024 Feb 3.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, while Po...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Apr;136:103645. doi: 10.1016/j.dnarep.2024.103645. Epub 2024 Feb 3.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, while Po...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Feb 3;136:103645. doi: 10.1016/j.dnarep.2024.103645. Online ahead of print.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, ...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Feb 3;136:103645. doi: 10.1016/j.dnarep.2024.103645. Online ahead of print.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, ...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Feb 3;136:103645. doi: 10.1016/j.dnarep.2024.103645. Online ahead of print.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, ...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Feb 3;136:103645. doi: 10.1016/j.dnarep.2024.103645. Online ahead of print.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, ...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Repair (Amst). 2024 Feb 3;136:103645. doi: 10.1016/j.dnarep.2024.103645. Online ahead of print.ABSTRACTDNA polymerases lambda (Polλ) and mu (Polμ) are X-Family polymerases that participate in DNA double-strand break (DSB) repair by the nonhomologous end-joining pathway (NHEJ). Both polymerases direct synthesis from one DSB end, using template derived from a second DSB end. In this way, they promote the NHEJ ligation step and minimize the sequence loss normally associated with this pathway. The two polymerases differ in cognate substrate, as Polλ is preferred when synthesis must be primed from a base-paired DSB end, ...
Source: DNA Repair - March 1, 2024 Category: Genetics & Stem Cells Authors: Andrea M Kaminski Kishore K Chiruvella Dale A Ramsden Katarzyna Bebenek Thomas A Kunkel Lars C Pedersen Source Type: research
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity
DNA Repair (Amst). 2024 Feb 28;136:103633. doi: 10.1016/j.dnarep.2024.103633. Online ahead of print.ABSTRACTInherited photosensitivity syndromes are a heterogeneous group of genetic skin disorders with tremendous phenotypic variability, characterized by photosensitivity and defective DNA repair, especially nucleotide excision repair. A cohort of 17 Iranian families with heritable photosensitivity syndromes was evaluated to identify their genetic defect. The patients' DNA was analyzed with either whole-exome sequencing or RNA sequencing (RNA-Seq). The interpretations of the genomic results were guided by genome-wide homozyg...
Source: DNA Repair - February 29, 2024 Category: Genetics & Stem Cells Authors: Amir Hozhabrpour Marzieh Mojbafan Fahimeh Palizban Fatemeh Vahidnezhad Saeed Talebi Maliheh Amani Masoud Garshasbi Anoosh Naghavi Raziyeh Khalesi Parvin Mansouri Soheila Sotoudeh Hamidreza Mahmoudi Aida Varghaei Maryam Daneshpazhooh Fatemeh Karimi Sirous Source Type: research
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity
DNA Repair (Amst). 2024 Feb 28;136:103633. doi: 10.1016/j.dnarep.2024.103633. Online ahead of print.ABSTRACTInherited photosensitivity syndromes are a heterogeneous group of genetic skin disorders with tremendous phenotypic variability, characterized by photosensitivity and defective DNA repair, especially nucleotide excision repair. A cohort of 17 Iranian families with heritable photosensitivity syndromes was evaluated to identify their genetic defect. The patients' DNA was analyzed with either whole-exome sequencing or RNA sequencing (RNA-Seq). The interpretations of the genomic results were guided by genome-wide homozyg...
Source: DNA Repair - February 29, 2024 Category: Genetics & Stem Cells Authors: Amir Hozhabrpour Marzieh Mojbafan Fahimeh Palizban Fatemeh Vahidnezhad Saeed Talebi Maliheh Amani Masoud Garshasbi Anoosh Naghavi Raziyeh Khalesi Parvin Mansouri Soheila Sotoudeh Hamidreza Mahmoudi Aida Varghaei Maryam Daneshpazhooh Fatemeh Karimi Sirous Source Type: research
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
DNA Repair (Amst). 2024 Mar;135:103648. doi: 10.1016/j.dnarep.2024.103648. Epub 2024 Feb 15.ABSTRACTDNA damage response (DDR) is a complex process, essential for cell survival. Especially deleterious type of DNA damage are DNA double-strand breaks (DSB), which can lead to genomic instability and malignant transformation if not repaired correctly. The central player in DSB detection and repair is the ATM kinase which orchestrates the action of several downstream factors. Recent studies have suggested that long non-coding RNAs (lncRNAs) are involved in DDR. Here, we aimed to identify lncRNAs induced upon DNA damage in an ATM...
Source: DNA Repair - February 21, 2024 Category: Genetics & Stem Cells Authors: Marta Podralska Marcin Piotr Sajek Antonina Bielicka Magdalena Żurawek Iwona Zi ółkowska-Suchanek Katarzyna I żykowska Tomasz Kolenda Marta Kazimierska Marta El żbieta Kasprzyk Weronika Sura Barbara Pietrucha Bo żena Cukrowska Natalia Rozwadowska Ag Source Type: research
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
DNA Repair (Amst). 2024 Feb 15;135:103648. doi: 10.1016/j.dnarep.2024.103648. Online ahead of print.ABSTRACTDNA damage response (DDR) is a complex process, essential for cell survival. Especially deleterious type of DNA damage are DNA double-strand breaks (DSB), which can lead to genomic instability and malignant transformation if not repaired correctly. The central player in DSB detection and repair is the ATM kinase which orchestrates the action of several downstream factors. Recent studies have suggested that long non-coding RNAs (lncRNAs) are involved in DDR. Here, we aimed to identify lncRNAs induced upon DNA damage i...
Source: DNA Repair - February 21, 2024 Category: Genetics & Stem Cells Authors: Marta Podralska Marcin Piotr Sajek Antonina Bielicka Magdalena Żurawek Iwona Zi ółkowska-Suchanek Katarzyna I żykowska Tomasz Kolenda Marta Kazimierska Marta El żbieta Kasprzyk Weronika Sura Barbara Pietrucha Bo żena Cukrowska Natalia Rozwadowska Ag Source Type: research
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
DNA Repair (Amst). 2024 Feb 15;135:103648. doi: 10.1016/j.dnarep.2024.103648. Online ahead of print.ABSTRACTDNA damage response (DDR) is a complex process, essential for cell survival. Especially deleterious type of DNA damage are DNA double-strand breaks (DSB), which can lead to genomic instability and malignant transformation if not repaired correctly. The central player in DSB detection and repair is the ATM kinase which orchestrates the action of several downstream factors. Recent studies have suggested that long non-coding RNAs (lncRNAs) are involved in DDR. Here, we aimed to identify lncRNAs induced upon DNA damage i...
Source: DNA Repair - February 21, 2024 Category: Genetics & Stem Cells Authors: Marta Podralska Marcin Piotr Sajek Antonina Bielicka Magdalena Żurawek Iwona Zi ółkowska-Suchanek Katarzyna I żykowska Tomasz Kolenda Marta Kazimierska Marta El żbieta Kasprzyk Weronika Sura Barbara Pietrucha Bo żena Cukrowska Natalia Rozwadowska Ag Source Type: research
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
DNA Repair (Amst). 2024 Feb 15;135:103648. doi: 10.1016/j.dnarep.2024.103648. Online ahead of print.ABSTRACTDNA damage response (DDR) is a complex process, essential for cell survival. Especially deleterious type of DNA damage are DNA double-strand breaks (DSB), which can lead to genomic instability and malignant transformation if not repaired correctly. The central player in DSB detection and repair is the ATM kinase which orchestrates the action of several downstream factors. Recent studies have suggested that long non-coding RNAs (lncRNAs) are involved in DDR. Here, we aimed to identify lncRNAs induced upon DNA damage i...
Source: DNA Repair - February 21, 2024 Category: Genetics & Stem Cells Authors: Marta Podralska Marcin Piotr Sajek Antonina Bielicka Magdalena Żurawek Iwona Zi ółkowska-Suchanek Katarzyna I żykowska Tomasz Kolenda Marta Kazimierska Marta El żbieta Kasprzyk Weronika Sura Barbara Pietrucha Bo żena Cukrowska Natalia Rozwadowska Ag Source Type: research
