Evolution of the triplet BRCT domain
DNA Repair (Amst). 2023 Jul 6;129:103532. doi: 10.1016/j.dnarep.2023.103532. Online ahead of print.ABSTRACTOrganisms have evolved a complex system, called the DNA damage response (DDR), which maintains genome integrity. The DDR is responsible for identifying and repairing a variety of lesions and alterations in DNA. DDR proteins coordinate DNA damage detection, cell cycle arrest, and repair, with many of these events regulated by protein phosphorylation. In the human proteome, 23 proteins contain the BRCT (BRCA1 C-Terminus domain) domain, a modular signaling domain that can bind phosphopeptides and mediate protein-protein ...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: M B S Mota N T Woods M A Carvalho A N A Monteiro R D Mesquita Source Type: research
The roles of non-productive complexes of DNA repair proteins with DNA lesions
DNA Repair (Amst). 2023 Jul 12;129:103542. doi: 10.1016/j.dnarep.2023.103542. Online ahead of print.ABSTRACTA multitude of different types of lesions is continuously introduced into the DNA inside our cells, and their rapid and efficient repair is fundamentally important for the maintenance of genomic stability and cellular viability. This is achieved by a number of DNA repair systems that each involve different protein factors and employ versatile strategies to target different types of DNA lesions. Intriguingly, specialized DNA repair proteins have also evolved to form non-functional complexes with their target lesions. ...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: Ingrid Tessmer Source Type: research
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment
DNA Repair (Amst). 2023 Jun 30;129:103531. doi: 10.1016/j.dnarep.2023.103531. Online ahead of print.ABSTRACTDNA replication stress (RS) is frequently induced by oncogene activation and is believed to promote tumorigenesis. However, clinical evidence for the role of oncogene-induced RS in tumorigenesis remains scarce, and the mechanisms by which RS promotes cancer development remain incompletely understood. By performing a series of bioinformatic analyses on the oncogene E2F1, other RS-inducing factors, and replication fork processing factors in TCGA cancer database using previously established tools, we show that hyperacti...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: Ke Tan Yizhe Song Min Xu Zhongsheng You Source Type: research
Evolution of the triplet BRCT domain
DNA Repair (Amst). 2023 Jul 6;129:103532. doi: 10.1016/j.dnarep.2023.103532. Online ahead of print.ABSTRACTOrganisms have evolved a complex system, called the DNA damage response (DDR), which maintains genome integrity. The DDR is responsible for identifying and repairing a variety of lesions and alterations in DNA. DDR proteins coordinate DNA damage detection, cell cycle arrest, and repair, with many of these events regulated by protein phosphorylation. In the human proteome, 23 proteins contain the BRCT (BRCA1 C-Terminus domain) domain, a modular signaling domain that can bind phosphopeptides and mediate protein-protein ...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: M B S Mota N T Woods M A Carvalho A N A Monteiro R D Mesquita Source Type: research
The roles of non-productive complexes of DNA repair proteins with DNA lesions
DNA Repair (Amst). 2023 Jul 12;129:103542. doi: 10.1016/j.dnarep.2023.103542. Online ahead of print.ABSTRACTA multitude of different types of lesions is continuously introduced into the DNA inside our cells, and their rapid and efficient repair is fundamentally important for the maintenance of genomic stability and cellular viability. This is achieved by a number of DNA repair systems that each involve different protein factors and employ versatile strategies to target different types of DNA lesions. Intriguingly, specialized DNA repair proteins have also evolved to form non-functional complexes with their target lesions. ...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: Ingrid Tessmer Source Type: research
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment
DNA Repair (Amst). 2023 Jun 30;129:103531. doi: 10.1016/j.dnarep.2023.103531. Online ahead of print.ABSTRACTDNA replication stress (RS) is frequently induced by oncogene activation and is believed to promote tumorigenesis. However, clinical evidence for the role of oncogene-induced RS in tumorigenesis remains scarce, and the mechanisms by which RS promotes cancer development remain incompletely understood. By performing a series of bioinformatic analyses on the oncogene E2F1, other RS-inducing factors, and replication fork processing factors in TCGA cancer database using previously established tools, we show that hyperacti...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: Ke Tan Yizhe Song Min Xu Zhongsheng You Source Type: research
Evolution of the triplet BRCT domain
DNA Repair (Amst). 2023 Jul 6;129:103532. doi: 10.1016/j.dnarep.2023.103532. Online ahead of print.ABSTRACTOrganisms have evolved a complex system, called the DNA damage response (DDR), which maintains genome integrity. The DDR is responsible for identifying and repairing a variety of lesions and alterations in DNA. DDR proteins coordinate DNA damage detection, cell cycle arrest, and repair, with many of these events regulated by protein phosphorylation. In the human proteome, 23 proteins contain the BRCT (BRCA1 C-Terminus domain) domain, a modular signaling domain that can bind phosphopeptides and mediate protein-protein ...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: M B S Mota N T Woods M A Carvalho A N A Monteiro R D Mesquita Source Type: research
The roles of non-productive complexes of DNA repair proteins with DNA lesions
DNA Repair (Amst). 2023 Jul 12;129:103542. doi: 10.1016/j.dnarep.2023.103542. Online ahead of print.ABSTRACTA multitude of different types of lesions is continuously introduced into the DNA inside our cells, and their rapid and efficient repair is fundamentally important for the maintenance of genomic stability and cellular viability. This is achieved by a number of DNA repair systems that each involve different protein factors and employ versatile strategies to target different types of DNA lesions. Intriguingly, specialized DNA repair proteins have also evolved to form non-functional complexes with their target lesions. ...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: Ingrid Tessmer Source Type: research
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment
DNA Repair (Amst). 2023 Jun 30;129:103531. doi: 10.1016/j.dnarep.2023.103531. Online ahead of print.ABSTRACTDNA replication stress (RS) is frequently induced by oncogene activation and is believed to promote tumorigenesis. However, clinical evidence for the role of oncogene-induced RS in tumorigenesis remains scarce, and the mechanisms by which RS promotes cancer development remain incompletely understood. By performing a series of bioinformatic analyses on the oncogene E2F1, other RS-inducing factors, and replication fork processing factors in TCGA cancer database using previously established tools, we show that hyperacti...
Source: DNA Repair - July 15, 2023 Category: Genetics & Stem Cells Authors: Ke Tan Yizhe Song Min Xu Zhongsheng You Source Type: research
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults
DNA Repair (Amst). 2023 Jun 29;129:103530. doi: 10.1016/j.dnarep.2023.103530. Online ahead of print.ABSTRACTFrailty is an age-related syndrome characterized by reduced recovery from stressors and increased risks of morbidity and mortality. Although frailty is usually studied in those over 65 years, our previous work showed that frailty is both present and a risk factor for premature mortality in midlife. We identified altered gene expression patterns and biological pathways associated with inflammation in frailty. Evidence suggests DNA oxidation damage related to inflammation accumulates with age, and that DNA repair capac...
Source: DNA Repair - July 12, 2023 Category: Genetics & Stem Cells Authors: Jessica T Smith Nicole Noren Hooten Nicolle A Mode Alan B Zonderman Ngozi Ezike Simran Kaushal Michele K Evans Source Type: research
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults
DNA Repair (Amst). 2023 Jun 29;129:103530. doi: 10.1016/j.dnarep.2023.103530. Online ahead of print.ABSTRACTFrailty is an age-related syndrome characterized by reduced recovery from stressors and increased risks of morbidity and mortality. Although frailty is usually studied in those over 65 years, our previous work showed that frailty is both present and a risk factor for premature mortality in midlife. We identified altered gene expression patterns and biological pathways associated with inflammation in frailty. Evidence suggests DNA oxidation damage related to inflammation accumulates with age, and that DNA repair capac...
Source: DNA Repair - July 12, 2023 Category: Genetics & Stem Cells Authors: Jessica T Smith Nicole Noren Hooten Nicolle A Mode Alan B Zonderman Ngozi Ezike Simran Kaushal Michele K Evans Source Type: research
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults
DNA Repair (Amst). 2023 Jun 29;129:103530. doi: 10.1016/j.dnarep.2023.103530. Online ahead of print.ABSTRACTFrailty is an age-related syndrome characterized by reduced recovery from stressors and increased risks of morbidity and mortality. Although frailty is usually studied in those over 65 years, our previous work showed that frailty is both present and a risk factor for premature mortality in midlife. We identified altered gene expression patterns and biological pathways associated with inflammation in frailty. Evidence suggests DNA oxidation damage related to inflammation accumulates with age, and that DNA repair capac...
Source: DNA Repair - July 12, 2023 Category: Genetics & Stem Cells Authors: Jessica T Smith Nicole Noren Hooten Nicolle A Mode Alan B Zonderman Ngozi Ezike Simran Kaushal Michele K Evans Source Type: research
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance
DNA Repair (Amst). 2023 Aug;128:103526. doi: 10.1016/j.dnarep.2023.103526. Epub 2023 Jun 17.ABSTRACTDNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are responsible fo...
Source: DNA Repair - July 5, 2023 Category: Genetics & Stem Cells Authors: Mokhtar Jawad Al-Imam Uday Abdul-Reda Hussein Fadhil Faez Sead Ayoob Murtadha Alshaikh Faqri Shereen M Mekkey Abdullah Jalel Khazel Haider Abdulkareem Almashhadani Source Type: research
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance
DNA Repair (Amst). 2023 Aug;128:103526. doi: 10.1016/j.dnarep.2023.103526. Epub 2023 Jun 17.ABSTRACTDNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are responsible fo...
Source: DNA Repair - July 5, 2023 Category: Genetics & Stem Cells Authors: Mokhtar Jawad Al-Imam Uday Abdul-Reda Hussein Fadhil Faez Sead Ayoob Murtadha Alshaikh Faqri Shereen M Mekkey Abdullah Jalel Khazel Haider Abdulkareem Almashhadani Source Type: research
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance
DNA Repair (Amst). 2023 Aug;128:103526. doi: 10.1016/j.dnarep.2023.103526. Epub 2023 Jun 17.ABSTRACTDNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are responsible fo...
Source: DNA Repair - July 5, 2023 Category: Genetics & Stem Cells Authors: Mokhtar Jawad Al-Imam Uday Abdul-Reda Hussein Fadhil Faez Sead Ayoob Murtadha Alshaikh Faqri Shereen M Mekkey Abdullah Jalel Khazel Haider Abdulkareem Almashhadani Source Type: research
