Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
DNA Repair (Amst). 2023 Dec 13;134:103613. doi: 10.1016/j.dnarep.2023.103613. Online ahead of print.ABSTRACTRAD51 recombinase plays a central role in homologous recombination (HR) by forming a nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and strand exchange between the ssDNA and a homologous double-stranded DNA (dsDNA). The catalytic activity of RAD51 assembled on ssDNA is critical for the DNA-homology-mediated repair of DNA double-strand breaks in somatic and meiotic cells and restarting stalled replication forks during DNA replication. The RAD51-ssDNA complex also plays a structural r...
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Masaru Ito Yurika Fujita Akira Shinohara Source Type: research
Cutting Edge Perspectives in genome maintenance X
DNA Repair (Amst). 2023 Dec 20;134:103614. doi: 10.1016/j.dnarep.2023.103614. Online ahead of print.NO ABSTRACTPMID:38143231 | DOI:10.1016/j.dnarep.2023.103614 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Ann Jeggo Source Type: research
Contents of previous 3 special issues in this series of perspectives
DNA Repair (Amst). 2023 Dec 20;134:103615. doi: 10.1016/j.dnarep.2023.103615. Online ahead of print.NO ABSTRACTPMID:38142594 | DOI:10.1016/j.dnarep.2023.103615 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Jeggo Source Type: research
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
DNA Repair (Amst). 2023 Dec 13;134:103613. doi: 10.1016/j.dnarep.2023.103613. Online ahead of print.ABSTRACTRAD51 recombinase plays a central role in homologous recombination (HR) by forming a nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and strand exchange between the ssDNA and a homologous double-stranded DNA (dsDNA). The catalytic activity of RAD51 assembled on ssDNA is critical for the DNA-homology-mediated repair of DNA double-strand breaks in somatic and meiotic cells and restarting stalled replication forks during DNA replication. The RAD51-ssDNA complex also plays a structural r...
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Masaru Ito Yurika Fujita Akira Shinohara Source Type: research
Cutting Edge Perspectives in genome maintenance X
DNA Repair (Amst). 2023 Dec 20:103614. doi: 10.1016/j.dnarep.2023.103614. Online ahead of print.NO ABSTRACTPMID:38143231 | DOI:10.1016/j.dnarep.2023.103614 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Ann Jeggo Source Type: research
Contents of previous 3 special issues in this series of perspectives
DNA Repair (Amst). 2023 Dec 20;134:103615. doi: 10.1016/j.dnarep.2023.103615. Online ahead of print.NO ABSTRACTPMID:38142594 | DOI:10.1016/j.dnarep.2023.103615 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Jeggo Source Type: research
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
DNA Repair (Amst). 2023 Dec 13;134:103613. doi: 10.1016/j.dnarep.2023.103613. Online ahead of print.ABSTRACTRAD51 recombinase plays a central role in homologous recombination (HR) by forming a nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and strand exchange between the ssDNA and a homologous double-stranded DNA (dsDNA). The catalytic activity of RAD51 assembled on ssDNA is critical for the DNA-homology-mediated repair of DNA double-strand breaks in somatic and meiotic cells and restarting stalled replication forks during DNA replication. The RAD51-ssDNA complex also plays a structural r...
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Masaru Ito Yurika Fujita Akira Shinohara Source Type: research
Cutting Edge Perspectives in genome maintenance X
DNA Repair (Amst). 2023 Dec 20:103614. doi: 10.1016/j.dnarep.2023.103614. Online ahead of print.NO ABSTRACTPMID:38143231 | DOI:10.1016/j.dnarep.2023.103614 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Ann Jeggo Source Type: research
Contents of previous 3 special issues in this series of perspectives
DNA Repair (Amst). 2023 Dec 20;134:103615. doi: 10.1016/j.dnarep.2023.103615. Online ahead of print.NO ABSTRACTPMID:38142594 | DOI:10.1016/j.dnarep.2023.103615 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Jeggo Source Type: research
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
DNA Repair (Amst). 2023 Dec 13;134:103613. doi: 10.1016/j.dnarep.2023.103613. Online ahead of print.ABSTRACTRAD51 recombinase plays a central role in homologous recombination (HR) by forming a nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and strand exchange between the ssDNA and a homologous double-stranded DNA (dsDNA). The catalytic activity of RAD51 assembled on ssDNA is critical for the DNA-homology-mediated repair of DNA double-strand breaks in somatic and meiotic cells and restarting stalled replication forks during DNA replication. The RAD51-ssDNA complex also plays a structural r...
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Masaru Ito Yurika Fujita Akira Shinohara Source Type: research
Cutting Edge Perspectives in genome maintenance X
DNA Repair (Amst). 2023 Dec 20:103614. doi: 10.1016/j.dnarep.2023.103614. Online ahead of print.NO ABSTRACTPMID:38143231 | DOI:10.1016/j.dnarep.2023.103614 (Source: DNA Repair)
Source: DNA Repair - December 24, 2023 Category: Genetics & Stem Cells Authors: Penny Ann Jeggo Source Type: research
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways
This article reviews DNA curtain techniques and their applications for imaging DNA repair proteins.PMID:38128155 | DOI:10.1016/j.dnarep.2023.103612 (Source: DNA Repair)
Source: DNA Repair - December 21, 2023 Category: Genetics & Stem Cells Authors: Subin Kim Youngseo Kim Ja Yil Lee Source Type: research
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways
This article reviews DNA curtain techniques and their applications for imaging DNA repair proteins.PMID:38128155 | DOI:10.1016/j.dnarep.2023.103612 (Source: DNA Repair)
Source: DNA Repair - December 21, 2023 Category: Genetics & Stem Cells Authors: Subin Kim Youngseo Kim Ja Yil Lee Source Type: research
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways
This article reviews DNA curtain techniques and their applications for imaging DNA repair proteins.PMID:38128155 | DOI:10.1016/j.dnarep.2023.103612 (Source: DNA Repair)
Source: DNA Repair - December 21, 2023 Category: Genetics & Stem Cells Authors: Subin Kim Youngseo Kim Ja Yil Lee Source Type: research
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
DNA Repair (Amst). 2023 Dec 5;133:103611. doi: 10.1016/j.dnarep.2023.103611. Online ahead of print.ABSTRACTWEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an attractive target for cancer therapy due to the simultaneous induction of replication stress and inhibition of the G2/M checkpoint. WEE1 inhibition in cancer cells with high levels of replication stress results in induction of replication catastrophe and mitotic catastrophe. To increase potential as a single agent chemotherapeutic, a better understanding of genetic alterations that impact cellular res...
Source: DNA Repair - December 16, 2023 Category: Genetics & Stem Cells Authors: Lucy Jennings Heather Andrews Walters Tyler J McCraw Joshua L Turner Jennifer M Mason Source Type: research
