Reducing residual cardiovascular risk with novel therapies
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
Editorial: Nitro-fatty acids: novel drug candidates for the co-treatment of atherosclerosis and nonalcoholic fatty liver disease
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
Editorial: Clonal hematopoiesis: a link between inflammation, ageing and cardiovascular disease
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
Are dietary fish oil supplements appropriate for dyslipidemia management? A review of the evidence
Purpose of review
The purpose of this review is to assess whether dietary fish oil supplements can be appropriate for patients with elevated triglycerides and cardiovascular risk based on a comprehensive analysis of their composition, and level of regulatory oversight.
Recent findings
Approximately 19 million people in the United States take fish oil supplements, many for the purpose of treating or preventing heart disease. Unlike prescription products, fish oil supplements are classified as food by the Food and Drug Administration (FDA) and are not required to undergo manufacturing oversight or clinical testing. Anal...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Using the electronic health record for genomics research
Purpose of review
Although primarily designed for medical documentation and billing purposes, the electronic health record (EHR) has significant potential for translational research. In this article, we provide an overview of the use of the EHR for genomics research with a focus on heritable lipid disorders.
Recent findings
Linking the EHR to genomic data enables repurposing of vast phenotype data for genomic discovery. EHR data can be used to study the genetic basis of common and rare disorders, identify subphenotypes of diseases, assess pathogenicity of novel genomic variants, investigate pleiotropy, and rapidly ass...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Tangier disease: update for 2020
Purpose of review
To appraise recent advances in our knowledge of the severe genetic HDL deficiency disorder, Tangier disease.
Recent findings
While Tangier disease can cause premature atherosclerotic cardiovascular disease (ASCVD), new evidence suggests that heterozygous ABCA1 variant carriers are also at increased risk. Advances have been made in the study of the neurological abnormalities observed in Tangier disease, both in their assessment and the identification of potential new therapies.
Summary
Tangier disease is an extremely rare condition and, as such, the published literature around its range of clinical...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Novel lecithin: cholesterol acyltransferase-based therapeutic approaches
Purpose of review
To review recent lecithin:cholesterol acyltransferas (LCAT)-based therapeutic approaches for atherosclerosis, acute coronary syndrome, and LCAT deficiency disorders.
Recent findings
A wide variety of approaches to using LCAT as a novel therapeutic target have been proposed. Enzyme replacement therapy with recombinant human LCAT is the most clinically advanced therapy for atherosclerosis and familial LCAT deficiency (FLD), with Phase I and Phase 2A clinical trials recently completed. Liver-directed LCAT gene therapy and engineered cell therapies are also another promising approach. Peptide and small m...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Inborn errors of apolipoprotein A-I metabolism: implications for disease, research and development
Purpose of review
We review current knowledge regarding naturally occurring mutations in the human apolipoprotein A-I (APOA1) gene with a focus on their clinical complications as well as their exploitation for the elucidation of structure–function–(disease) relationships and therapy.
Recent findings
Bi-allelic loss-of-function mutations in APOA1 cause HDL deficiency and, in the majority of patients, premature atherosclerotic cardiovascular disease (ASCVD) and corneal opacities. Heterozygous HDL-cholesterol decreasing mutations in APOA1 were associated with increased risk of ASCVD in several but not all studies. So...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Autosomal recessive hypercholesterolemia: update for 2020
Purpose of review
This review summarizes the current knowledge regarding autosomal recessive hypercholesterolemia (ARH) and provides new insight into the natural history and therapeutic management of this lipid disorder.
Recent findings
Novel homozygous and compound heterozygous ARH-causing mutations have been reported in the literature, to date. The long-term follow-up of a cohort of ARH patients demonstrated that, despite intensive treatment with conventional lipid-lowering therapies, their low-density lipoprotein (LDL) cholesterol levels remain far from target and this translates into a poor cardiovascular prognosi...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease
Purpose of review
Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia (ABL). Mutations in the angiopoietin-like protein 3 ANGPTL3 gene cause familial combined hypolipidemia (FHBL2). Clinical manifestations range from none-to-severe, debilitating and life-threatening disorders. This review summarizes recent genetic, metabolic and clinical findings and management strategies.
...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency
Purpose of review
Angiopoietin-like protein-3 (ANGPTL3) is emerging as a key player in lipoprotein transport with an expanding role on fatty acid and glucose metabolism. Its deficiency is associated with a favorable metabolic profile. The present review will highlight the recent understanding of metabolic and cardiovascular consequences of ANGPTL3 inactivation by considering both genetic and pharmacological investigations.
Recent findings
Experimental studies have further illustrated the complex interplay between ANGPTL3 and ANGPTL4–8 in orchestrating lipid transport in different nutritional status. Individuals with...
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Editorial introduction
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - March 6, 2020 Category: Lipidology Tags: EDITORIAL INTRODUCTION Source Type: research
Omega-3 fatty acids: new insights into the impact of eicosapentaenoic and docosahexaenoic acids on lipid and lipoprotein metabolism
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - January 2, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
Atherosclerosis: cell biology and lipoproteins
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - January 2, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
Therapy and clinical trials
No abstract available (Source: Current Opinion in Lipidology)
Source: Current Opinion in Lipidology - January 2, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
