CONTINUUM: Lifelong Learning in Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Learning Objectives and Core Competencies
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: LEARNING OBJECTIVES AND CORE COMPETENCIES Source Type: research

Postreading Self-Assessment and CME Test—Preferred Responses
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: SELF-ASSESSMENT AND CME Source Type: research

Postreading Self-Assessment and CME Test
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: SELF-ASSESSMENT AND CME Source Type: research

Self-assessment and cme
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: SELF-ASSESSMENT AND CME Source Type: research

The Medicolegal and Ethical Dimensions of Physician Prescription Reluctance
This article addresses the potential legal ramifications for neurologists caring for patients with Alzheimer disease (AD) who elect neither to prescribe aducanumab nor to refer patients with AD for treatment with aducanumab. To prevail against a neurologist for failing to prescribe aducanumab or refer for aducanumab treatment, the plaintiff would have to establish that the neurologist’s failure to prescribe the medication or refer for treatment was a breach of the standard of care. The standard of care is conceptualized as the generally accepted approach to diagnosing or treating a condition. However, the controversy sur...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: MEDICOLEGAL ISSUES Source Type: research

Rapidly Progressive Dementia
This article presents a practical approach to the evaluation of patients with rapidly progressive dementia. RECENT FINDINGS The approach presented in this article builds upon the standard dementia evaluation, leveraging widely available tests and emergent specific markers of disease to narrow the differential diagnosis and determine the cause(s) of rapid progressive decline. The discovery of treatment-responsive causes of rapidly progressive dementia underscores the need to determine the cause early in the symptomatic course when treatments are most likely to halt or reverse cognitive decline. SUMMARY A pragm...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Management of Dementia
This article describes an approach to managing patients following a diagnosis of dementia, including medical management, nonpharmacologic strategies, safety interventions, caregiver support, mobilization of community resources, and advanced care planning. RECENT FINDINGS Dementia clinical syndromes are frequently caused by mixed pathologies, leading to varied clinical presentations that include memory loss, behavioral changes, communication challenges, safety concerns, and loss of independent function. Medications for treating dementia currently target cognitive and behavioral symptoms, although disease-modifying th...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Health Disparities in Dementia
This article contextualizes health disparities as they relate to the neurodegenerative processes of ADRD. RECENT FINDINGS Older adults’ life expectancy has increased such that a 65-year-old is expected to live 19 or more years and an 85-year-old can expect to live, on average, 6 to 7 years longer. Individuals of certain ethnoracial groups (Black, Hispanic/Latino, American Indian/Alaska Native, and Native Hawaiian/Pacific Islander) may be at a higher risk of incident ADRD compared to non-Hispanic/Latino White people. These differences in a higher risk of ADRD across ethnoracial groups persist despite no statistical...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Genetics of Alzheimer Disease
This article discusses the spectrum of genetic risk in familial and sporadic forms of early- and late-onset Alzheimer disease (AD). Recent work illuminating the complex genetic architecture of AD is discussed in the context of high and low risk and what is known in different populations. RECENT FINDINGS A small proportion of AD is autosomal dominant familial AD caused by variants in PSEN1, PSEN2, or APP, although more recently described rare genetic changes can also increase risk substantially over the general population, with odds ratios estimated at 2 to 4. APOE remains the strongest genetic risk factor for late-o...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Neuropathology of Dementia Disorders
This article provides an overview of the neuropathology of common age-related dementing disorders, focusing on the pathologies that underlie Alzheimer disease (AD) and related dementias, including Lewy body dementias, frontotemporal dementia, vascular dementia, limbic-predominant age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy (LATE), and mixed-etiology dementias. This article also discusses the underlying proteinopathies of neurodegenerative diseases (eg, amyloid-β, paired helical filament tau, α-synuclein, and TDP-43 pathology) and vascular pathologies, including tissue injury (eg, infar...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Fluid Biomarkers in Dementia Diagnosis
This article discusses how fluid biomarkers can augment the routine dementia evaluation and improve diagnostic accuracy. The tests that are currently available and the indications for their use are described. Further, tests that are under development and likely to be used in the future are identified. RECENT FINDINGS Technical improvements in assay sensitivity and precision have led to the rapid development of blood-based biomarkers for Alzheimer disease (AD) over the past several years. Studies have found that the ratio of amyloid-β (Aβ) peptides (Aβ42/Aβ40) and concentrations of phosphorylated tau isoforms in ...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

The Value of Neuroimaging in Dementia Diagnosis
This article discusses neuroimaging in dementia diagnosis, with a focus on new applications of MRI and positron emission tomography (PET). RECENT FINDINGS Although the historical use of MRI in dementia diagnosis has been supportive to exclude structural etiologies, recent innovations allow for quantification of atrophy patterns that improve sensitivity for supporting the diagnosis of dementia causes. Neuronuclear approaches allow for localization of specific amyloid and tau neuropathology on PET and are available for clinical use, in addition to dopamine transporter scans in dementia with Lewy bodies and metabolic s...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Neuropsychological Assessment in Dementia Diagnosis
This article discusses the application of neuropsychological evaluation to the workup of individuals with age-related cognitive impairment and suspected dementia. Referral questions, principles of evaluation, and common instruments to detect abnormalities in cognition and behavior in this population are reviewed. The integration of neuropsychological test findings with other clinical and biomarker information enhances early detection, differential diagnosis, and care planning. RECENT FINDINGS Life expectancy is increasing in the United States, and, accordingly, the prevalence and incidence of dementia associated wit...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Vascular Cognitive Impairment and Dementia
This article gives a broad overview of vascular cognitive impairment and dementia, including epidemiology, pathophysiology, clinical approach, and management. Emphasis is placed on understanding the common underlying types of cerebrovascular disease (including atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy) and awareness of rare inherited cerebrovascular disorders. RECENT FINDINGS The pathophysiology of vascular cognitive impairment and dementia is heterogeneous, and the most recent diagnostic criteria for vascular cognitive impairment and dementia break down the diagnosis of major vascular dem...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Cognitive Syndromes Associated With Movement Disorders
This article reviews the recognition and management of cognitive syndromes in movement disorders, including those with parkinsonism, chorea, ataxia, dystonia, and tremor. RECENT FINDINGS Cognitive and motor syndromes are often intertwined in neurologic disorders, including neurodegenerative diseases such as Parkinson disease, atypical parkinsonian syndromes, Huntington disease, and other movement disorders. Cognitive symptoms often affect attention, working memory, and executive and visuospatial functions preferentially, rather than language and memory, but heterogeneity can be seen in the various movement disorders...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research