CONTINUUM: Lifelong Learning in Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Learning Objectives
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: LEARNING OBJECTIVES AND CORE COMPETENCIES Source Type: research

Erratum
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: Erratum Source Type: research

Postreading Self-Assessment and CME Test—Preferred Responses
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: SELF-ASSESSMENT AND CME Source Type: research

Postreading Self-Assessment and CME Test
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: SELF-ASSESSMENT AND CME Source Type: research

Instructions for Completing CME and Tally Sheet
No abstract available (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: SELF-ASSESSMENT AND CME Source Type: research

Rising Drug Costs for Neurologic Diseases
The cost of prescription drugs in the United States is rising like never before and has led to an inflection point where clinicians must consider the potential financial damage to the patient and to society related to the more expensive drugs available. Many of the highest-priced drugs are approved as orphan drugs, a legally defined status providing additional benefits to pharmaceutical companies that is intended to incentivize therapeutic development for rare diseases. The Orphan Drug Act has been a great success since it was enacted in 1983, resulting in the development of many innovative, life-changing, and even lifesav...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: PRACTICE ISSUES Source Type: research

Test Utilization and Value in the Evaluation of Peripheral Neuropathies
This article describes two cases to illustrate the appropriate diagnostic workup of those with typical or atypical neuropathy. (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: PRACTICE ISSUES Source Type: research

Peripheral Neuropathies Associated With Monoclonal Gammopathies
This article discusses how to approach patients with monoclonal gammopathy and peripheral neuropathy, highlighting clinical and laboratory clues that may aid in establishing a diagnosis in a timely manner. RECENT FINDINGS From a hematologic standpoint, a monoclonal gammopathy may be of undetermined significance or can be associated with an underlying myeloma, lymphoplasmacytic lymphoma, or amyloidosis. Each of these conditions can cause peripheral neuropathy, with varying clinical and electrodiagnostic profiles. Treatment usually consists of treating the underlying hematologic disorder. IgM-associated peripheral neuropa...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Spinal Muscular Atrophy
This article provides an overview of the pathophysiology and clinical presentations of spinal muscular atrophy (SMA) and reviews therapeutic developments, including US Food and Drug Administration (FDA)–approved gene-targeted therapies and mainstays of supportive SMA care. RECENT FINDINGS Over the past decades, an understanding of the role of SMN protein in the development and maintenance of the motor unit and the intricate genetics underlying SMA has led to striking developments in therapeutics with three FDA-approved treatments for SMA, one targeting SMN1 gene replacement (onasemnogene abeparvovec-xioi) and two othe...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
This article reviews the clinical features, diagnostic approach, and treatments available for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. The article also provides an update on the genetics and pathophysiology of ALS. RECENT FINDINGS ALS remains a clinical diagnosis without a unique biomarker. The areas of greatest progress include a large expansion in the number of genes associated with familial and sporadic ALS. The discovery of these genes, along with other work, has provided a deeper understanding of the mechanisms of motor neuron failure in ALS. Areas of particular interest include the role...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Management of Neuropathic Pain in Polyneuropathy
This article reviews recent literature on complementary and pharmacologic therapies for the management of painful polyneuropathies. Exercise has emerged as an important therapeutic tool and may also improve the underlying polyneuropathy in the setting of obesity, metabolic syndrome, and diabetes. SUMMARY The approach to management of painful polyneuropathies is multifactorial, using both pharmacologic and nonpharmacologic measures to improve pain severity and patient quality of life. (Source: CONTINUUM: Lifelong Learning in Neurology)
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Peripheral Neuropathies Due to Vitamin and Mineral Deficiencies, Toxins, and Medications
This article provides a comprehensive approach and list of items that must be considered in the setting of new-onset neuropathy. RECENT FINDINGS Although many of the neuropathies described in this article have decreased in prevalence in developed countries because of public health interventions and occupational/environmental regulations, new causes for this class of neuropathy continue to be uncovered. SUMMARY The peripheral nervous system is susceptible to a broad array of metabolic and toxic abnormalities, which most often lead to a length-dependent sensory-predominant axonal peripheral neuropathy. A careful histor...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Peripheral Neuropathies Associated With Vasculitis and Autoimmune Connective Tissue Disease
This article discusses peripheral neuropathies associated with vasculitis (isolated or in the setting of systemic vasculitis) and autoimmune connective tissue disease and provides a brief overview of their diagnostic evaluation and management. RECENT FINDINGS The classification of systemic vasculitic neuropathy and nonsystemic vasculitic neuropathy continues to evolve. Classification according to the presence of antineutrophil cytoplasmic antibodies and their subtypes facilitates prognostication and management. Recent research on antineutrophil cytoplasmic antibody–associated vasculitis has added to our understanding ...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Charcot-Marie-Tooth Disease and Other Hereditary Neuropathies
This article provides an overview of Charcot-Marie-Tooth disease (CMT) and other inherited neuropathies. These disorders encompass a broad spectrum with variable motor, sensory, autonomic, and other organ system involvement. Considerable overlap exists, both phenotypically and genetically, among these separate categories, all eventually exhibiting axonal injury and neurologic impairment. Depending on the specific neural and non-neural localizations, patients experience varying morbidity and mortality. Neurologic evaluations, including neurophysiologic testing, can help diagnose and predict patient disabilities. Diagnosis i...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Its Variants
This article highlights the clinical presentation, pathophysiology, diagnostic evaluation, and treatment approach of these polyneuropathies. RECENT FINDINGS The spectrum of CIDP is expanding with the recent characterization of neuropathies associated with nodal and paranodal antibodies. These neuropathies are distinguished by their unique presentations and are often refractory to IV immunoglobulin (IVIg) therapy. Subcutaneous immunoglobulins have recently been approved as a treatment option for CIDP and join corticosteroids, IVIg, and plasma exchange as first-line treatment. SUMMARY CIDP is characterized by progressi...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research