Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gaillardin exerts potent antileukemic effects on HL-60 cells and intensifies arsenic trioxide cytotoxicity: Providing new insight into sesquiterpene lactones in leukaemia treatment
Clin Exp Pharmacol Physiol. 2024 Apr;51(4):e13847. doi: 10.1111/1440-1681.13847.ABSTRACTThe use of all-trans retinoic acid and arsenic trioxide resulted in favourable therapeutic responses in standard-risk acute promyelocytic leukaemia (APL) patients. However, resistance to these agents has made treating the high-risk subgroup more problematic, and possible side effects limit their clinical dosages. Numerous studies have proven the cytotoxic properties of Gaillardin, one of the Inula oculus-christi-derived sesquiterpene lactones. Due to the adverse effects of arsenic trioxide on the high-risk subgroup of APL patients, we a...
Source: Clinical and Experimental Pharmacology and Physiology - February 21, 2024 Category: Drugs & Pharmacology Authors: Hanieh Noormohamadi Maryam Hamzeloo-Moghadam Davood Bashash Maryam Kargar Mehrdad Izadirad Seyedeh Zahra Hasanpour Ahmad Gharehbaghian Source Type: research

Dapagliflozin alleviates high glucose-induced injury of endothelial cells via inducing autophagy
In this study, we aimed to investigate whether DAPA plays a protective role against high glucose (HG)-induced endothelial injury through regulating autophagy. The results showed that DAPA treatment resulted in increased cell viability. Additionally, DAPA treatment decreased interleukin (IL)-1β, IL-6, and tumour necrosis factor-α levels in endothelial cells subjected to HG conditions. We observed that HG inhibited autophagy, and DAPA increased the autophagy level by inhibiting the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway. Chloroquine reversed all of these beneficial effects as an auto...
Source: Clinical and Experimental Pharmacology and Physiology - February 21, 2024 Category: Drugs & Pharmacology Authors: Gen Li Ningxin Hou Huagang Liu Jun Li Hongping Deng Hongwen Lan Sizheng Xiong Source Type: research

Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation
In this study, Scu was evidenced to efficaciously attenuate oleic acid (OA)-induced lipid accumulation and the upregulation of adipose differentiation-associated protein Plin2 in a dose- and time-responsive manner. We elucidated that Scu effectively diminishes OA-provoked VSMC foam cell formation. Further, it was established that Scu pretreatment augments the protein expression of LC3B-II and the mRNA levels of Map1lc3b and Becn1, concurrently diminishing the protein levels of the NLRP3 inflammasome compared to the OA group. Activation of autophagy through rapamycin attenuated NLRP3 inflammasome protein expression, intrace...
Source: Clinical and Experimental Pharmacology and Physiology - February 21, 2024 Category: Drugs & Pharmacology Authors: Wen-Cong Gao Tie-Hua Yang Bin-Bao Wang Qian Liu Qing Li Xiao-Huan Zhou Chang-Bo Zheng Peng Chen Source Type: research

Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel-mediated oxidative stress
In conclusion, by increasing the susceptibility of HT29 tumour cells to oxidative stress and apoptosis, the combined administration of BoNT and OXA via the targeting of TRPM2 may offer a different approach to kill the tumour cells.PMID:38350599 | DOI:10.1111/1440-1681.13844 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - February 13, 2024 Category: Drugs & Pharmacology Authors: S ıdıka Demir İpek Duman Mustafa Naz ıroğlu Source Type: research

Empagliflozin attenuates liver fibrosis in high-fat diet/streptozotocin-induced mice by modulating gut microbiota
This study aimed to investigate the effects of empagliflozin on liver fibrosis in high-fat diet/streptozotocin-induced mice and the correlation with gut microbiota. After the application of empagliflozin for 6 weeks, we performed oral glucose tolerance and intraperitoneal insulin tolerance tests to assess glucose tolerance and insulin resistance, and stained liver sections to evaluate histochemical and hepatic pathological markers of liver fibrosis. Moreover, 16S rRNA amplicon sequencing was performed on stool samples to explore changes in the composition of intestinal bacteria. We finally analysed the correlation between ...
Source: Clinical and Experimental Pharmacology and Physiology - February 1, 2024 Category: Drugs & Pharmacology Authors: Chuxin Huang Jiali Qian Ying Liu Li Zhang Yehong Yang Source Type: research

Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas
This study explores the potential mechanisms of obstructive sleep apnoea (OSA) complicates type 2 diabetes mellitus (T2DM) by which chronic intermittent hypoxia (CIH) induces insulin resistance and cell apoptosis in the pancreas through oxidative stress. Four- and eight-week CIH rat models were established, and Tempol (100 mg/kg/d), was used as an oxidative stress inhibitor. This study included five groups: 4-week CIH, 4-week CIH-Tempol, 8-week CIH, 8-week CIH-Tempol and normal control (NC) groups. Fasting blood glucose and insulin levels were measured in the serum. The expression levels of 8-hidroxy-2-deoxyguanosine (8-OH...
Source: Clinical and Experimental Pharmacology and Physiology - February 1, 2024 Category: Drugs & Pharmacology Authors: Shan Zeng Yeying Wang Li Ai Liwei Huang Zhijuan Liu Chunxia He Qiaohui Bai Yongxia Li Source Type: research

Comparison of the negative effect of remimazolam and propofol on cardiac contractility: Analysis of a randomised parallel-group trial and a preclinical ex vivo study
This study aimed to clarify the effects of remimazolam on cardiac contractility. In a randomised-parallel group trial, haemodynamic parameters were compared between propofol (n = 11) and remimazolam (n = 12) groups during the induction of general anaesthesia in patients undergoing non-cardiac surgery. In a preclinical study, the direct effects of remimazolam on cardiac contractility were also evaluated using isolated rat hearts. RNA sequence data obtained from rat and human hearts were analysed to assess the expression patterns of the cardiac γ-aminobutyric acid type A (GABAA ) receptor subunits. In a clinical study, the ...
Source: Clinical and Experimental Pharmacology and Physiology - February 1, 2024 Category: Drugs & Pharmacology Authors: Yusuke Yoshikawa Shunsuke Oura Masatoshi Kanda Tomohiro Chaki Naoyuki Hirata Mitsutaka Edanaga Michiaki Yamakage Source Type: research

Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve
In conclusion, the study revealed AA-induced neurodegeneration in the brain and sciatic nerve, with CRV significantly mitigating this neurotoxicity. This novel research underscores CRV's promise as a neuroprotective agent against AA-induced adverse effects in both the central and peripheral nervous systems.PMID:38302077 | DOI:10.1111/1440-1681.13841 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - February 1, 2024 Category: Drugs & Pharmacology Authors: Hatipoglu Durmus Ates M Burak Senturk Goktug Bulut Aysegul Source Type: research

Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial
Clin Exp Pharmacol Physiol. 2024 Mar;51(3):e13836. doi: 10.1111/1440-1681.13836.ABSTRACTThe pharmacodynamics in patients with high body fat percentage might be similar to those in obese patients. This randomised controlled clinical trial observed the effects of rocuronium in patients with different percent body fats (PBFs). Fifty-four patients who underwent elective urological or pelvic surgery under general anaesthesia at Shanghai General Hospital were included in the present study; 51 patients were included for data analysis. Patients with normal PBF (<25%) were given a single dose of rocuronium calculated based on to...
Source: Clinical and Experimental Pharmacology and Physiology - February 1, 2024 Category: Drugs & Pharmacology Authors: Guanghui An Yan Qiu Zheliang Zhou Xueying Ding Cheng Li Source Type: research

Dihydromyricetin reverses capecitabine-induced peripheral myelin dysfunction through modulation of oxidative stress
Clin Exp Pharmacol Physiol. 2024 Mar;51(3):e13833. doi: 10.1111/1440-1681.13833.ABSTRACTPrevious clinical reports have shown that capecitabine, an oral prodrug of 5-fluorouracil (5-Fu), can induce peripheral neuropathy, resulting in numbness, paresthesia and hypoesthesia. However, the mechanism through which capecitabine causes peripheral nerve injury remains unclear. Here, we demonstrate that systemic administration of capecitabine leads to myelin abnormalities in the peripheral nerves of mice, which are possibly attributed to the death of Schwann cells, the myelinating cells in the peripheral nervous system. Furthermore,...
Source: Clinical and Experimental Pharmacology and Physiology - February 1, 2024 Category: Drugs & Pharmacology Authors: Jie Fang Shuyi Lou Xinyi Zhou Dayong Lou Liqin Zhou Rong Bian Source Type: research