Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Jul 15. doi: 10.1111/1440-1681.13805. Online ahead of print.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis and c...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research