Clinical and Experimental Pharmacology and Physiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Correction to geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1
Clin Exp Pharmacol Physiol. 2023 Aug 31. doi: 10.1111/1440-1681.13820. Online ahead of print.NO ABSTRACTPMID:37652083 | DOI:10.1111/1440-1681.13820 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 31, 2023 Category: Drugs & Pharmacology Source Type: research
Artesunate alleviates psoriasis-like dermatitis by reducing interleukin-23 expression in tumor necrosis factor-alpha-induced HaCaT cells
This study found that IL-23 is highly expressed in the epidermis of psoriasis lesions and positively correlated with histological neutrophil infiltration and clinical psoriasis area and severity index (PASI) scores. Furthermore, ART inhibits the migration and cell cycle, as well as tumor necrosis factor-alpha (TNF-α)-induced IL-23 expression in HaCaT cells in a dose-dependent manner, probably through interference with the nuclear factor kappa B (NF-κB) signalling pathway. Animal experiments in imiquimod (IMQ)-induced psoriasis-like mice model also suggested that ART dose-dependently reduces IL-23 in the epidermis and ame...
Source: Clinical and Experimental Pharmacology and Physiology - August 28, 2023 Category: Drugs & Pharmacology Authors: Lixian Lin Zhongzhou Huang Ma Jianchi Zhixuan Guo Zhenrui Shi Zengqi Tang Qing Guo Hui Xiong Source Type: research
Artesunate alleviates psoriasis-like dermatitis by reducing interleukin-23 expression in tumor necrosis factor-alpha-induced HaCaT cells
This study found that IL-23 is highly expressed in the epidermis of psoriasis lesions and positively correlated with histological neutrophil infiltration and clinical psoriasis area and severity index (PASI) scores. Furthermore, ART inhibits the migration and cell cycle, as well as tumor necrosis factor-alpha (TNF-α)-induced IL-23 expression in HaCaT cells in a dose-dependent manner, probably through interference with the nuclear factor kappa B (NF-κB) signalling pathway. Animal experiments in imiquimod (IMQ)-induced psoriasis-like mice model also suggested that ART dose-dependently reduces IL-23 in the epidermis and ame...
Source: Clinical and Experimental Pharmacology and Physiology - August 28, 2023 Category: Drugs & Pharmacology Authors: Lixian Lin Zhongzhou Huang Ma Jianchi Zhixuan Guo Zhenrui Shi Zengqi Tang Qing Guo Hui Xiong Source Type: research
Artesunate alleviates psoriasis-like dermatitis by reducing interleukin-23 expression in tumor necrosis factor-alpha-induced HaCaT cells
This study found that IL-23 is highly expressed in the epidermis of psoriasis lesions and positively correlated with histological neutrophil infiltration and clinical psoriasis area and severity index (PASI) scores. Furthermore, ART inhibits the migration and cell cycle, as well as tumor necrosis factor-alpha (TNF-α)-induced IL-23 expression in HaCaT cells in a dose-dependent manner, probably through interference with the nuclear factor kappa B (NF-κB) signalling pathway. Animal experiments in imiquimod (IMQ)-induced psoriasis-like mice model also suggested that ART dose-dependently reduces IL-23 in the epidermis and ame...
Source: Clinical and Experimental Pharmacology and Physiology - August 28, 2023 Category: Drugs & Pharmacology Authors: Lixian Lin Zhongzhou Huang Ma Jianchi Zhixuan Guo Zhenrui Shi Zengqi Tang Qing Guo Hui Xiong Source Type: research
Artesunate alleviates psoriasis-like dermatitis by reducing interleukin-23 expression in tumor necrosis factor-alpha-induced HaCaT cells
This study found that IL-23 is highly expressed in the epidermis of psoriasis lesions and positively correlated with histological neutrophil infiltration and clinical psoriasis area and severity index (PASI) scores. Furthermore, ART inhibits the migration and cell cycle, as well as tumor necrosis factor-alpha (TNF-α)-induced IL-23 expression in HaCaT cells in a dose-dependent manner, probably through interference with the nuclear factor kappa B (NF-κB) signalling pathway. Animal experiments in imiquimod (IMQ)-induced psoriasis-like mice model also suggested that ART dose-dependently reduces IL-23 in the epidermis and ame...
Source: Clinical and Experimental Pharmacology and Physiology - August 28, 2023 Category: Drugs & Pharmacology Authors: Lixian Lin Zhongzhou Huang Ma Jianchi Zhixuan Guo Zhenrui Shi Zengqi Tang Qing Guo Hui Xiong Source Type: research
Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models
Clin Exp Pharmacol Physiol. 2023 Aug 25. doi: 10.1111/1440-1681.13817. Online ahead of print.ABSTRACTThe hypothalamic-pituitary-gonadal (HPG) axis is an important regulatory mechanism involved primarily in the development and regulation of the reproductive systems. The suppression of the HPG axis by gonadotropin-releasing hormone (GnRH) analogues is expected to be effective for the treatment of sex hormone-dependent diseases, such as endometriosis, uterine fibroid, prostate cancer, benign prostatic hyperplasia (BPH) and polycystic ovary syndrome (PCOS). Despite the established involvement of GnRH signalling in these disord...
Source: Clinical and Experimental Pharmacology and Physiology - August 25, 2023 Category: Drugs & Pharmacology Authors: Motohiro Tezuka Saori Yonekubo-Awaka Yasuaki Tamai Kumi Tsuchioka Kaoru Kobayashi Yu Kuramochi Satoshi Tatemichi Tatsuya Nagasawa Sumiyoshi Kiguchi Source Type: research
Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models
Clin Exp Pharmacol Physiol. 2023 Aug 25. doi: 10.1111/1440-1681.13817. Online ahead of print.ABSTRACTThe hypothalamic-pituitary-gonadal (HPG) axis is an important regulatory mechanism involved primarily in the development and regulation of the reproductive systems. The suppression of the HPG axis by gonadotropin-releasing hormone (GnRH) analogues is expected to be effective for the treatment of sex hormone-dependent diseases, such as endometriosis, uterine fibroid, prostate cancer, benign prostatic hyperplasia (BPH) and polycystic ovary syndrome (PCOS). Despite the established involvement of GnRH signalling in these disord...
Source: Clinical and Experimental Pharmacology and Physiology - August 25, 2023 Category: Drugs & Pharmacology Authors: Motohiro Tezuka Saori Yonekubo-Awaka Yasuaki Tamai Kumi Tsuchioka Kaoru Kobayashi Yu Kuramochi Satoshi Tatemichi Tatsuya Nagasawa Sumiyoshi Kiguchi Source Type: research
Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models
Clin Exp Pharmacol Physiol. 2023 Aug 25. doi: 10.1111/1440-1681.13817. Online ahead of print.ABSTRACTThe hypothalamic-pituitary-gonadal (HPG) axis is an important regulatory mechanism involved primarily in the development and regulation of the reproductive systems. The suppression of the HPG axis by gonadotropin-releasing hormone (GnRH) analogues is expected to be effective for the treatment of sex hormone-dependent diseases, such as endometriosis, uterine fibroid, prostate cancer, benign prostatic hyperplasia (BPH) and polycystic ovary syndrome (PCOS). Despite the established involvement of GnRH signalling in these disord...
Source: Clinical and Experimental Pharmacology and Physiology - August 25, 2023 Category: Drugs & Pharmacology Authors: Motohiro Tezuka Saori Yonekubo-Awaka Yasuaki Tamai Kumi Tsuchioka Kaoru Kobayashi Yu Kuramochi Satoshi Tatemichi Tatsuya Nagasawa Sumiyoshi Kiguchi Source Type: research
Evaluation of right atrium structure and function in a rat model of monocrotaline-induced pulmonary hypertension: Exploring the possible antiarrhythmic properties of amiodarone
Clin Exp Pharmacol Physiol. 2023 Aug 23. doi: 10.1111/1440-1681.13813. Online ahead of print.ABSTRACTAtrial arrhythmias (AA) are common in pulmonary hypertension (PH) and are closely associated with poor clinical outcomes. One of the most studied models to investigate PH is the rat model of monocrotaline (MCT) induced PH (MCT-PH). To date, little is known about right atrium (RA) function in the MCT-PH model and the propensity of RA to develop arrhythmias. Therefore, the aim of the study was to evaluate the function of the RA of control (CTRL) and MCT treated rats, and the ability of amiodarone, a classical antiarrhythmic, ...
Source: Clinical and Experimental Pharmacology and Physiology - August 23, 2023 Category: Drugs & Pharmacology Authors: Jorge Lucas Teixeira-Fonseca Julliane Vasconcelos Joviano-Santos Fabiana da Silva Alc ântara Michael Ramon de Lima Concei ção Polyana Leal-Silva Danilo Roman-Campos Source Type: research
Evaluation of right atrium structure and function in a rat model of monocrotaline-induced pulmonary hypertension: Exploring the possible antiarrhythmic properties of amiodarone
Clin Exp Pharmacol Physiol. 2023 Aug 23. doi: 10.1111/1440-1681.13813. Online ahead of print.ABSTRACTAtrial arrhythmias (AA) are common in pulmonary hypertension (PH) and are closely associated with poor clinical outcomes. One of the most studied models to investigate PH is the rat model of monocrotaline (MCT) induced PH (MCT-PH). To date, little is known about right atrium (RA) function in the MCT-PH model and the propensity of RA to develop arrhythmias. Therefore, the aim of the study was to evaluate the function of the RA of control (CTRL) and MCT treated rats, and the ability of amiodarone, a classical antiarrhythmic, ...
Source: Clinical and Experimental Pharmacology and Physiology - August 23, 2023 Category: Drugs & Pharmacology Authors: Jorge Lucas Teixeira-Fonseca Julliane Vasconcelos Joviano-Santos Fabiana da Silva Alc ântara Michael Ramon de Lima Concei ção Polyana Leal-Silva Danilo Roman-Campos Source Type: research
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome
Clin Exp Pharmacol Physiol. 2023 Aug 21. doi: 10.1111/1440-1681.13814. Online ahead of print.ABSTRACTBerberine (BBR) is an isoquinoline alkaloid extracted from Chinese medicinal plants showing a tight correlation with gut microbiota. Polycystic ovary syndrome (PCOS) is a prevalent reproductive and endocrine disorder syndrome among women of childbearing age. Dysbiosis, the imbalance of intestinal microorganisms, is a potential factor that takes part in the pathogenesis of PCOS. Recent evidence indicates that berberine offers promise for treating PCOS. Here, we review the recent research on the interaction between berberine ...
Source: Clinical and Experimental Pharmacology and Physiology - August 21, 2023 Category: Drugs & Pharmacology Authors: Ting-Wei Zhu Xue-Lian Li Source Type: research
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome
Clin Exp Pharmacol Physiol. 2023 Aug 21. doi: 10.1111/1440-1681.13814. Online ahead of print.ABSTRACTBerberine (BBR) is an isoquinoline alkaloid extracted from Chinese medicinal plants showing a tight correlation with gut microbiota. Polycystic ovary syndrome (PCOS) is a prevalent reproductive and endocrine disorder syndrome among women of childbearing age. Dysbiosis, the imbalance of intestinal microorganisms, is a potential factor that takes part in the pathogenesis of PCOS. Recent evidence indicates that berberine offers promise for treating PCOS. Here, we review the recent research on the interaction between berberine ...
Source: Clinical and Experimental Pharmacology and Physiology - August 21, 2023 Category: Drugs & Pharmacology Authors: Ting-Wei Zhu Xue-Lian Li Source Type: research
Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy
This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX-resulted enteritis.PMID:37582493 | DOI:10.1111/1440-1681.13810 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 15, 2023 Category: Drugs & Pharmacology Authors: Tongao Yang Wuying Lang Yun Zhao Yahan Yang Hongli Liu Sufen Li Xianglong Li Shuangqi Zhang Haihua Zhang Source Type: research
Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy
This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX-resulted enteritis.PMID:37582493 | DOI:10.1111/1440-1681.13810 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 15, 2023 Category: Drugs & Pharmacology Authors: Tongao Yang Wuying Lang Yun Zhao Yahan Yang Hongli Liu Sufen Li Xianglong Li Shuangqi Zhang Haihua Zhang Source Type: research
Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy
This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX-resulted enteritis.PMID:37582493 | DOI:10.1111/1440-1681.13810 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 15, 2023 Category: Drugs & Pharmacology Authors: Tongao Yang Wuying Lang Yun Zhao Yahan Yang Hongli Liu Sufen Li Xianglong Li Shuangqi Zhang Haihua Zhang Source Type: research
