Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis
CONCLUSIONS: In summary, these data suggest that TAN IIA can reduce SSc-related skin fibrosis by modulating the TGF-β/Smad and MAPK/ERK signalling pathways. More importantly, our results imply that TAN IIA can directly act on the skin fibroblasts of SSc, therefore, inhibiting fibrosis.PMID:38037494 | DOI:10.1111/1440-1681.13834 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - December 1, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Feifei Hu Ming Li Qiao Li Source Type: research

Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis
CONCLUSIONS: In summary, these data suggest that TAN IIA can reduce SSc-related skin fibrosis by modulating the TGF-β/Smad and MAPK/ERK signalling pathways. More importantly, our results imply that TAN IIA can directly act on the skin fibroblasts of SSc, therefore, inhibiting fibrosis.PMID:38037494 | DOI:10.1111/1440-1681.13834 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - December 1, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Feifei Hu Ming Li Qiao Li Source Type: research

Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis
CONCLUSIONS: In summary, these data suggest that TAN IIA can reduce SSc-related skin fibrosis by modulating the TGF-β/Smad and MAPK/ERK signalling pathways. More importantly, our results imply that TAN IIA can directly act on the skin fibroblasts of SSc, therefore, inhibiting fibrosis.PMID:38037494 | DOI:10.1111/1440-1681.13834 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - December 1, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Feifei Hu Ming Li Qiao Li Source Type: research

Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis
CONCLUSIONS: In summary, these data suggest that TAN IIA can reduce SSc-related skin fibrosis by modulating the TGF-β/Smad and MAPK/ERK signalling pathways. More importantly, our results imply that TAN IIA can directly act on the skin fibroblasts of SSc, therefore, inhibiting fibrosis.PMID:38037494 | DOI:10.1111/1440-1681.13834 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - December 1, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Feifei Hu Ming Li Qiao Li Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart
Clin Exp Pharmacol Physiol. 2023 Nov 23. doi: 10.1111/1440-1681.13835. Online ahead of print.ABSTRACTIschemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron transport chain complex III, can be used to reduce reactive oxygen species production during blood reperfusion by slowing th...
Source: Clinical and Experimental Pharmacology and Physiology - November 23, 2023 Category: Drugs & Pharmacology Authors: Shuo Wang Wenjun Liu Shan Liu Jiacong Li Yi Geng Yungang Zhao Source Type: research

Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats
Clin Exp Pharmacol Physiol. 2023 Nov 11. doi: 10.1111/1440-1681.13832. Online ahead of print.ABSTRACTOne of the major contributors to secondary osteoporosis is long-term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti-inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid-promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg, s.c.), twice weekly for 12 weeks; rats of group III had agomelatine (40 mg/kg/day, orally), as a positive control, daily ...
Source: Clinical and Experimental Pharmacology and Physiology - November 11, 2023 Category: Drugs & Pharmacology Authors: Samaa M El-Mahroky Mahitab M Nageeb Dalia A Hemead Enas G Abd Allah Source Type: research

Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats
Clin Exp Pharmacol Physiol. 2023 Nov 11. doi: 10.1111/1440-1681.13832. Online ahead of print.ABSTRACTOne of the major contributors to secondary osteoporosis is long-term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti-inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid-promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg, s.c.), twice weekly for 12 weeks; rats of group III had agomelatine (40 mg/kg/day, orally), as a positive control, daily ...
Source: Clinical and Experimental Pharmacology and Physiology - November 11, 2023 Category: Drugs & Pharmacology Authors: Samaa M El-Mahroky Mahitab M Nageeb Dalia A Hemead Enas G Abd Allah Source Type: research

Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats
Clin Exp Pharmacol Physiol. 2023 Nov 11. doi: 10.1111/1440-1681.13832. Online ahead of print.ABSTRACTOne of the major contributors to secondary osteoporosis is long-term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti-inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid-promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg, s.c.), twice weekly for 12 weeks; rats of group III had agomelatine (40 mg/kg/day, orally), as a positive control, daily ...
Source: Clinical and Experimental Pharmacology and Physiology - November 11, 2023 Category: Drugs & Pharmacology Authors: Samaa M El-Mahroky Mahitab M Nageeb Dalia A Hemead Enas G Abd Allah Source Type: research

Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats
Clin Exp Pharmacol Physiol. 2023 Nov 11. doi: 10.1111/1440-1681.13832. Online ahead of print.ABSTRACTOne of the major contributors to secondary osteoporosis is long-term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti-inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid-promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg, s.c.), twice weekly for 12 weeks; rats of group III had agomelatine (40 mg/kg/day, orally), as a positive control, daily ...
Source: Clinical and Experimental Pharmacology and Physiology - November 11, 2023 Category: Drugs & Pharmacology Authors: Samaa M El-Mahroky Mahitab M Nageeb Dalia A Hemead Enas G Abd Allah Source Type: research