Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats
Clin Exp Pharmacol Physiol. 2023 Nov 11. doi: 10.1111/1440-1681.13832. Online ahead of print.ABSTRACTOne of the major contributors to secondary osteoporosis is long-term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti-inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid-promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg, s.c.), twice weekly for 12 weeks; rats of group III had agomelatine (40 mg/kg/day, orally), as a positive control, daily ...
Source: Clinical and Experimental Pharmacology and Physiology - November 11, 2023 Category: Drugs & Pharmacology Authors: Samaa M El-Mahroky Mahitab M Nageeb Dalia A Hemead Enas G Abd Allah Source Type: research

IL-4/STAT6 axis observed to reverse proliferative defect in SCA3 patient-derived neural progenitor cells
Clin Exp Pharmacol Physiol. 2023 Nov 7. doi: 10.1111/1440-1681.13831. Online ahead of print.ABSTRACTSpinocerebellar ataxia 3 (SCA3) is an incurable, neurodegenerative genetic disorder that leads to progressive cerebellar ataxia and other parkinsonian-like pathologies because of loss of cerebellar neurons. The role of an expanded polyglutamine aggregate on neural progenitor cells is unknown. Here, we show that SCA3 patient-specific induced neural progenitor cells (iNPCs) exhibit proliferative defects. Moreover, SCA3 iNPCs have reduced autophagic expression compared to control. Furthermore, although SCA3 iNPCs continue to pr...
Source: Clinical and Experimental Pharmacology and Physiology - November 7, 2023 Category: Drugs & Pharmacology Authors: Francis M Chen Huixian Li Dittman Lai-Shun Chung Angel T L Mak Fung Ping Leung Ho Yin Edwin Chan Wing Tak Wong Source Type: research

Correction to "Ginsenoside 20(S)-Rg3 upregulates HIF-1 α-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells"
Clin Exp Pharmacol Physiol. 2023 Dec;50(12):1005. doi: 10.1111/1440-1681.13827.NO ABSTRACTPMID:37918445 | DOI:10.1111/1440-1681.13827 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - November 2, 2023 Category: Drugs & Pharmacology Source Type: research

Pharmacogenomics and adverse effects of anti-infective drugs in children
Clin Exp Pharmacol Physiol. 2023 Oct 15. doi: 10.1111/1440-1681.13830. Online ahead of print.ABSTRACTChildren, as a special group, have their own peculiarities in terms of individualized medication use compared to adults. Adverse drug reactions have been an important issue that needs to be addressed in the hope of safe medication use in children, and the occurrence of adverse drug reactions is partly due to genetic factors. Anti-infective drugs are widely used in children, and they have always been an important cause of the occurrence of adverse reactions in children. Pharmacogenomic technologies are becoming increasingly ...
Source: Clinical and Experimental Pharmacology and Physiology - October 15, 2023 Category: Drugs & Pharmacology Authors: Xin Huang Biwen Hu Ling Ye Tong Li Li He Wei Tan Guoping Yang Jun-Ping Liu Chengxian Guo Source Type: research