Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome
Clin Exp Pharmacol Physiol. 2023 Aug 21. doi: 10.1111/1440-1681.13814. Online ahead of print.ABSTRACTBerberine (BBR) is an isoquinoline alkaloid extracted from Chinese medicinal plants showing a tight correlation with gut microbiota. Polycystic ovary syndrome (PCOS) is a prevalent reproductive and endocrine disorder syndrome among women of childbearing age. Dysbiosis, the imbalance of intestinal microorganisms, is a potential factor that takes part in the pathogenesis of PCOS. Recent evidence indicates that berberine offers promise for treating PCOS. Here, we review the recent research on the interaction between berberine ...
Source: Clinical and Experimental Pharmacology and Physiology - August 21, 2023 Category: Drugs & Pharmacology Authors: Ting-Wei Zhu Xue-Lian Li Source Type: research

Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy
This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX-resulted enteritis.PMID:37582493 | DOI:10.1111/1440-1681.13810 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 15, 2023 Category: Drugs & Pharmacology Authors: Tongao Yang Wuying Lang Yun Zhao Yahan Yang Hongli Liu Sufen Li Xianglong Li Shuangqi Zhang Haihua Zhang Source Type: research

Ligustrazine and liguzinediol protect against doxorubicin-induced cardiomyocytes injury by inhibiting mitochondrial apoptosis and autophagy
This study aims to investigate the potential protective effect of ligustrazine and its derivative liguzinediol on regulating DOX-induced cardiomyocyte apoptosis and explore the use of the embryonic rat heart-derived myoblast cell line H9C2 for identifying novel treatments for HF. The results indicated that it has been demonstrated to reverse myocardial infarction remodelling in failed hearts by promoting autophagy in salvaged cardiomyocytes and anti-apoptosis of cardiomyocytes in granulation tissue. Our study suggests that ligustrazine and liguzinediol can be a promising agents and autophagy is potential pathway in the man...
Source: Clinical and Experimental Pharmacology and Physiology - August 14, 2023 Category: Drugs & Pharmacology Authors: Naqi Lian Jing Tong Weijie Zhu Qinghai Meng Miao Jiang Mianli Bian Yu Li Source Type: research

Intraoperative hemodynamics and risk of cardiac surgery-associated acute kidney injury: An observation study and a feasibility clinical trial
Clin Exp Pharmacol Physiol. 2023 Aug 7. doi: 10.1111/1440-1681.13812. Online ahead of print.ABSTRACTTargeting greater pump flow and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) could potentially alleviate renal hypoxia and reduce the risk of postoperative acute kidney injury (AKI). Therefore, in an observational study of 93 patients undergoing on-pump cardiac surgery, we tested whether intraoperative hemodynamic management differed between patients who did and did not develop AKI. Then, in 20 patients, we assessed the feasibility of a larger-scale trial in which patients would be randomized to greater t...
Source: Clinical and Experimental Pharmacology and Physiology - August 7, 2023 Category: Drugs & Pharmacology Authors: Khin M Noe Andrea Don Andrew D Cochrane Michael Z L Zhu Jennifer P Ngo Julian A Smith Amanda G Thrift Johnny Vogiatjis Andrew Martin Rinaldo Bellomo James McMillan Roger G Evans Source Type: research