Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy
This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX-resulted enteritis.PMID:37582493 | DOI:10.1111/1440-1681.13810 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 15, 2023 Category: Drugs & Pharmacology Authors: Tongao Yang Wuying Lang Yun Zhao Yahan Yang Hongli Liu Sufen Li Xianglong Li Shuangqi Zhang Haihua Zhang Source Type: research

Ligustrazine and liguzinediol protect against doxorubicin-induced cardiomyocytes injury by inhibiting mitochondrial apoptosis and autophagy
This study aims to investigate the potential protective effect of ligustrazine and its derivative liguzinediol on regulating DOX-induced cardiomyocyte apoptosis and explore the use of the embryonic rat heart-derived myoblast cell line H9C2 for identifying novel treatments for HF. The results indicated that it has been demonstrated to reverse myocardial infarction remodelling in failed hearts by promoting autophagy in salvaged cardiomyocytes and anti-apoptosis of cardiomyocytes in granulation tissue. Our study suggests that ligustrazine and liguzinediol can be a promising agents and autophagy is potential pathway in the man...
Source: Clinical and Experimental Pharmacology and Physiology - August 14, 2023 Category: Drugs & Pharmacology Authors: Naqi Lian Jing Tong Weijie Zhu Qinghai Meng Miao Jiang Mianli Bian Yu Li Source Type: research

Intraoperative hemodynamics and risk of cardiac surgery-associated acute kidney injury: An observation study and a feasibility clinical trial
Clin Exp Pharmacol Physiol. 2023 Aug 7. doi: 10.1111/1440-1681.13812. Online ahead of print.ABSTRACTTargeting greater pump flow and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) could potentially alleviate renal hypoxia and reduce the risk of postoperative acute kidney injury (AKI). Therefore, in an observational study of 93 patients undergoing on-pump cardiac surgery, we tested whether intraoperative hemodynamic management differed between patients who did and did not develop AKI. Then, in 20 patients, we assessed the feasibility of a larger-scale trial in which patients would be randomized to greater t...
Source: Clinical and Experimental Pharmacology and Physiology - August 7, 2023 Category: Drugs & Pharmacology Authors: Khin M Noe Andrea Don Andrew D Cochrane Michael Z L Zhu Jennifer P Ngo Julian A Smith Amanda G Thrift Johnny Vogiatjis Andrew Martin Rinaldo Bellomo James McMillan Roger G Evans Source Type: research

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2
Clin Exp Pharmacol Physiol. 2023 Sep;50(9):757-765. doi: 10.1111/1440-1681.13805. Epub 2023 Jul 15.ABSTRACTMultiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. Ginsenoside Rh4 has been shown to inhibit tumour growth in many cancers. However, the role of ginsenoside Rh4 in MM and its reaction mechanism have not been reported so far. After the treatment with different concentrations of ginsenoside Rh4, the proliferation of NCI-H929 cells was detected by Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine staining. The cell apoptosis...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Qiuhua Ying Jinjie Lou Daibo Zheng Source Type: research

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats
In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague-Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1-day post-surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larg...
Source: Clinical and Experimental Pharmacology and Physiology - July 15, 2023 Category: Drugs & Pharmacology Authors: Yujiao Jin Weiyi Jin Qiushuang Sun Nan Li Meiling Jiang Yinfeng Liu Lixia Sun Source Type: research